(data stored in ACNUC8465 zone)

SWISSPROT: ACE2_CANGA

ID   ACE2_CANGA              Reviewed;         703 AA.
AC   Q6FJQ9;
DT   26-JUN-2013, integrated into UniProtKB/Swiss-Prot.
DT   19-JUL-2004, sequence version 1.
DT   30-AUG-2017, entry version 86.
DE   RecName: Full=Cell wall transcription factor ACE2;
GN   Name=ACE2; OrderedLocusNames=CAGL0M04323g;
OS   Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 /
OS   NRRL Y-65) (Yeast) (Torulopsis glabrata).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina;
OC   Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Nakaseomyces;
OC   Nakaseomyces/Candida clade.
OX   NCBI_TaxID=284593;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65;
RX   PubMed=15229592; DOI=10.1038/nature02579;
RA   Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S.,
RA   Lafontaine I., de Montigny J., Marck C., Neuveglise C., Talla E.,
RA   Goffard N., Frangeul L., Aigle M., Anthouard V., Babour A., Barbe V.,
RA   Barnay S., Blanchin S., Beckerich J.-M., Beyne E., Bleykasten C.,
RA   Boisrame A., Boyer J., Cattolico L., Confanioleri F., de Daruvar A.,
RA   Despons L., Fabre E., Fairhead C., Ferry-Dumazet H., Groppi A.,
RA   Hantraye F., Hennequin C., Jauniaux N., Joyet P., Kachouri R.,
RA   Kerrest A., Koszul R., Lemaire M., Lesur I., Ma L., Muller H.,
RA   Nicaud J.-M., Nikolski M., Oztas S., Ozier-Kalogeropoulos O.,
RA   Pellenz S., Potier S., Richard G.-F., Straub M.-L., Suleau A.,
RA   Swennen D., Tekaia F., Wesolowski-Louvel M., Westhof E., Wirth B.,
RA   Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M., Thierry A.,
RA   Bouchier C., Caudron B., Scarpelli C., Gaillardin C., Weissenbach J.,
RA   Wincker P., Souciet J.-L.;
RT   "Genome evolution in yeasts.";
RL   Nature 430:35-44(2004).
RN   [2]
RP   DISRUPTION PHENOTYPE.
RX   PubMed=15075283; DOI=10.1128/EC.3.2.546-552.2004;
RA   Kamran M., Calcagno A.M., Findon H., Bignell E., Jones M.D., Warn P.,
RA   Hopkins P., Denning D.W., Butler G., Rogers T., Muhlschlegel F.A.,
RA   Haynes K.;
RT   "Inactivation of transcription factor gene ACE2 in the fungal pathogen
RT   Candida glabrata results in hypervirulence.";
RL   Eukaryot. Cell 3:546-552(2004).
RN   [3]
RP   FUNCTION.
RX   PubMed=15825152; DOI=10.1002/pmic.200401064;
RA   Stead D., Findon H., Yin Z., Walker J., Selway L., Cash P.,
RA   Dujon B.A., Hennequin C., Brown A.J., Haynes K.;
RT   "Proteomic changes associated with inactivation of the Candida
RT   glabrata ACE2 virulence-moderating gene.";
RL   Proteomics 5:1838-1848(2005).
RN   [4]
RP   DISRUPTION PHENOTYPE.
RX   PubMed=16926418; DOI=10.1128/IAI.00817-06;
RA   MacCallum D.M., Findon H., Kenny C.C., Butler G., Haynes K.,
RA   Odds F.C.;
RT   "Different consequences of ACE2 and SWI5 gene disruptions for
RT   virulence of pathogenic and nonpathogenic yeasts.";
RL   Infect. Immun. 74:5244-5248(2006).
RN   [5]
RP   FUNCTION.
RX   PubMed=19941307; DOI=10.1002/pmic.200800706;
RA   Stead D.A., Walker J., Holcombe L., Gibbs S.R., Yin Z., Selway L.,
RA   Butler G., Brown A.J., Haynes K.;
RT   "Impact of the transcriptional regulator, Ace2, on the Candida
RT   glabrata secretome.";
RL   Proteomics 10:212-223(2010).
CC   -!- FUNCTION: Transcription factor involved in the RAM (regulation of
CC       ACE2 transcription factor and polarized morphogenesis) signaling
CC       network that regulates polarized morphogenesis. Regulates
CC       expression of genes involved in cell separation or other cell wall
CC       genes. Required for regulation of morphogenesis, cell separation,
CC       adherence, biofilm formation, invasion, as well as virulence.
CC       {ECO:0000269|PubMed:15825152, ECO:0000269|PubMed:19941307}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Note=Localized in the
CC       nuclei of daughter cells. {ECO:0000250}.
CC   -!- DISRUPTION PHENOTYPE: Leads to systemic infections characterized
CC       by fungal escape from the vasculature, tissue penetration,
CC       proliferation in vivo, and considerable overstimulation of the
CC       proinflammatory arm of the innate immune response.
CC       {ECO:0000269|PubMed:15075283, ECO:0000269|PubMed:16926418}.
DR   EMBL; CR380959; CAG62511.1; -; Genomic_DNA.
DR   RefSeq; XP_449535.1; XM_449535.1.
DR   ProteinModelPortal; Q6FJQ9; -.
DR   SMR; Q6FJQ9; -.
DR   STRING; 284593.XP_449535.1; -.
DR   EnsemblFungi; CAG62511; CAG62511; CAGL0M04323g.
DR   KEGG; cgr:CAGL0M04323g; -.
DR   CGD; CAL0136273; ACE2.
DR   EuPathDB; FungiDB:CAGL0M04323g; -.
DR   eggNOG; KOG1721; Eukaryota.
DR   eggNOG; COG5048; LUCA.
DR   HOGENOM; HOG000001123; -.
DR   InParanoid; Q6FJQ9; -.
DR   KO; K09238; -.
DR   OMA; FQHTPVK; -.
DR   OrthoDB; EOG092C0TBX; -.
DR   Proteomes; UP000002428; Chromosome M.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR   GO; GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.
DR   GO; GO:0071555; P:cell wall organization; IEA:UniProtKB-KW.
DR   GO; GO:0009405; P:pathogenesis; IMP:CGD.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:UniProtKB-KW.
DR   GO; GO:0006351; P:transcription, DNA-templated; IEA:UniProtKB-KW.
DR   InterPro; IPR013087; Znf_C2H2_type.
DR   SMART; SM00355; ZnF_C2H2; 3.
DR   SUPFAM; SSF57667; SSF57667; 1.
DR   PROSITE; PS00028; ZINC_FINGER_C2H2_1; 2.
DR   PROSITE; PS50157; ZINC_FINGER_C2H2_2; 3.
PE   3: Inferred from homology;
DR   PRODOM; Q6FJQ9.
DR   SWISS-2DPAGE; Q6FJQ9.
KW   Cell adhesion; Cell wall biogenesis/degradation; Coiled coil;
KW   Complete proteome; Metal-binding; Nucleus; Reference proteome; Repeat;
KW   Transcription; Transcription regulation; Virulence; Zinc; Zinc-finger.
FT   CHAIN         1    703       Cell wall transcription factor ACE2.
FT                                /FTId=PRO_0000422793.
FT   ZN_FING     523    547       C2H2-type 1. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00042}.
FT   ZN_FING     553    577       C2H2-type 2. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00042}.
FT   ZN_FING     581    602       C2H2-type 3. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00042}.
FT   COILED      148    187       {ECO:0000255}.
SQ   SEQUENCE   703 AA;  79480 MW;  E0960AA4A2AAF171 CRC64;
     MNTFQADWGE IPQMPKDQVF TPQDQLTNYN DNMMDNLLDF NYNDVDALLS EELKDLDIPL
     APSPRDLNMN AEQSLNWMQD IQGHRSNKPS MSHKRGMSGT AIFGFKNHNK TLSIASFSKN
     TDIINEAENE NVKGNTDNQN GFVLSQVLLK QQEELRLALE KQKEVNRNLE RQLRENRLQQ
     EHIQRVLHDQ EAVTSQLTAQ NVTESPSKQR SPTKYQGDDA IIVTKNSSSG GYVFPPPPRV
     TLNNEAVTPP LSFSRFSNID QMESSDPLNY LQPNADFTEA YASHKTPESS FGKEHASVLS
     TSEFLRPTNA ARESSSKAMY SSPNSMISPH RKKDSVLSTV STILQPQDDY QNTASPPSQM
     LNLEEANLEN EQKNNGKMLR APVEIMPTIP GSKNNTPMTA NKSGFMPQKH TFQHTPVKAK
     NNVDMNERSL VRPELSGTPL NKSVQNGMHF REEDDSNILH HISEIPQGST SHNNTTAGDD
     SNVSNRLQFS NTESSPSRQR KKPTTLPPGY IDRYVKELPD KNFECLFPNC GKFFRRRYNI
     KSHIQTHLED KPYKCDFEGC TKAFVRNHDL ARHKKTHDKH FSCPCGKKFS SEQSMMKHKN
     RHNCTGPARV PDSKMVSKSP RKQSSPTKLS SAIMNSPIKE NYLKENTNLH IDQLRMDPKM
     RNALEDGGLL KPVERTEAMA FPSPLSGYSD LGSPFRDLGT IEE
//

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