(data stored in ACNUC8465 zone)

SWISSPROT: Q6FJL4_CANGA

ID   Q6FJL4_CANGA            Unreviewed;       212 AA.
AC   Q6FJL4;
DT   19-JUL-2004, integrated into UniProtKB/TrEMBL.
DT   19-JUL-2004, sequence version 1.
DT   30-AUG-2017, entry version 61.
DE   RecName: Full=Derlin {ECO:0000256|RuleBase:RU363059};
GN   OrderedLocusNames=CAGL0M05379g {ECO:0000313|CGD:CAL0136985,
GN   ECO:0000313|EMBL:CAG62556.1};
OS   Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 /
OS   NRRL Y-65) (Yeast) (Torulopsis glabrata).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina;
OC   Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Nakaseomyces;
OC   Nakaseomyces/Candida clade.
OX   NCBI_TaxID=284593 {ECO:0000313|Proteomes:UP000002428};
RN   [1] {ECO:0000313|EMBL:CAG62556.1, ECO:0000313|Proteomes:UP000002428}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65
RC   {ECO:0000313|Proteomes:UP000002428};
RX   PubMed=15229592; DOI=10.1038/nature02579;
RG   Genolevures;
RA   Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S.,
RA   Lafontaine I., de Montigny J., Marck C., Neuveglise C., Talla E.,
RA   Goffard N., Frangeul L., Aigle M., Anthouard V., Babour A., Barbe V.,
RA   Barnay S., Blanchin S., Beckerich J.M., Beyne E., Bleykasten C.,
RA   Boisrame A., Boyer J., Cattolico L., Confanioleri F., de Daruvar A.,
RA   Despons L., Fabre E., Fairhead C., Ferry-Dumazet H., Groppi A.,
RA   Hantraye F., Hennequin C., Jauniaux N., Joyet P., Kachouri R.,
RA   Kerrest A., Koszul R., Lemaire M., Lesur I., Ma L., Muller H.,
RA   Nicaud J.M., Nikolski M., Oztas S., Ozier-Kalogeropoulos O.,
RA   Pellenz S., Potier S., Richard G.F., Straub M.L., Suleau A.,
RA   Swennene D., Tekaia F., Wesolowski-Louvel M., Westhof E., Wirth B.,
RA   Zeniou-Meyer M., Zivanovic I., Bolotin-Fukuhara M., Thierry A.,
RA   Bouchier C., Caudron B., Scarpelli C., Gaillardin C., Weissenbach J.,
RA   Wincker P., Souciet J.L.;
RT   "Genome evolution in yeasts.";
RL   Nature 430:35-44(2004).
CC   -!- FUNCTION: May be involved in the degradation of misfolded
CC       endoplasmic reticulum (ER) luminal proteins.
CC       {ECO:0000256|RuleBase:RU363059}.
CC   -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC       {ECO:0000256|RuleBase:RU363059}; Multi-pass membrane protein
CC       {ECO:0000256|RuleBase:RU363059}.
CC   -!- SIMILARITY: Belongs to the derlin family.
CC       {ECO:0000256|RuleBase:RU363059}.
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DR   EMBL; CR380959; CAG62556.1; -; Genomic_DNA.
DR   RefSeq; XP_449580.1; XM_449580.1.
DR   STRING; 284593.XP_449580.1; -.
DR   EnsemblFungi; CAG62556; CAG62556; CAGL0M05379g.
DR   KEGG; cgr:CAGL0M05379g; -.
DR   CGD; CAL0136985; CAGL0M05379g.
DR   EuPathDB; FungiDB:CAGL0M05379g; -.
DR   eggNOG; KOG0858; Eukaryota.
DR   eggNOG; COG5291; LUCA.
DR   HOGENOM; HOG000142324; -.
DR   InParanoid; Q6FJL4; -.
DR   KO; K13989; -.
DR   OMA; WISMINI; -.
DR   OrthoDB; EOG092C4FBZ; -.
DR   Proteomes; UP000002428; Chromosome M.
DR   GO; GO:0000839; C:Hrd1p ubiquitin ligase ERAD-L complex; IEA:EnsemblFungi.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0051787; F:misfolded protein binding; IEA:EnsemblFungi.
DR   GO; GO:0008233; F:peptidase activity; IEA:EnsemblFungi.
DR   GO; GO:0006515; P:misfolded or incompletely synthesized protein catabolic process; IEA:EnsemblFungi.
DR   GO; GO:0070843; P:misfolded protein transport; IEA:EnsemblFungi.
DR   GO; GO:0030970; P:retrograde protein transport, ER to cytosol; IEA:EnsemblFungi.
DR   GO; GO:0030433; P:ubiquitin-dependent ERAD pathway; IEA:EnsemblFungi.
DR   InterPro; IPR007599; DER1.
DR   PANTHER; PTHR11009; PTHR11009; 1.
PE   3: Inferred from homology;
DR   PRODOM; Q6FJL4.
DR   SWISS-2DPAGE; Q6FJL4.
KW   Complete proteome {ECO:0000313|Proteomes:UP000002428};
KW   Endoplasmic reticulum {ECO:0000256|RuleBase:RU363059};
KW   Membrane {ECO:0000256|RuleBase:RU363059};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002428};
KW   Transmembrane {ECO:0000256|RuleBase:RU363059};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU363059}.
FT   TRANSMEM     18     35       Helical. {ECO:0000256|RuleBase:RU363059}.
FT   TRANSMEM     56     76       Helical. {ECO:0000256|RuleBase:RU363059}.
FT   TRANSMEM     96    122       Helical. {ECO:0000256|RuleBase:RU363059}.
FT   TRANSMEM    142    163       Helical. {ECO:0000256|RuleBase:RU363059}.
SQ   SEQUENCE   212 AA;  24915 MW;  84578F7E1B3D2F4F CRC64;
     MDAVLLNIVN DVPVVTRYWT MGCIAVSALV RFNMINSIKM LYSYEIVFQK GHYERILYSL
     FDYGLFNWMS LMNIVIAANH LSFLENSFSL KRRYVWILFL TLCSLLGMSY FGQPVASLGV
     LLQENLSYYY LKKNNEQMNI RLFGNIAVSP LLVPFYLNCL LLFVYHMDVV EVAMFFLPGH
     IMFYMDDMLK RIYGVDLTKT PYDWWLGLKE TQ
//

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