(data stored in ACNUC8465 zone)

SWISSPROT: NPL4_CANGA

ID   NPL4_CANGA              Reviewed;         580 AA.
AC   Q6FJI2;
DT   10-JUN-2008, integrated into UniProtKB/Swiss-Prot.
DT   19-JUL-2004, sequence version 1.
DT   30-AUG-2017, entry version 76.
DE   RecName: Full=Nuclear protein localization protein 4;
GN   Name=NPL4; OrderedLocusNames=CAGL0M06105g;
OS   Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 /
OS   NRRL Y-65) (Yeast) (Torulopsis glabrata).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina;
OC   Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Nakaseomyces;
OC   Nakaseomyces/Candida clade.
OX   NCBI_TaxID=284593;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65;
RX   PubMed=15229592; DOI=10.1038/nature02579;
RA   Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S.,
RA   Lafontaine I., de Montigny J., Marck C., Neuveglise C., Talla E.,
RA   Goffard N., Frangeul L., Aigle M., Anthouard V., Babour A., Barbe V.,
RA   Barnay S., Blanchin S., Beckerich J.-M., Beyne E., Bleykasten C.,
RA   Boisrame A., Boyer J., Cattolico L., Confanioleri F., de Daruvar A.,
RA   Despons L., Fabre E., Fairhead C., Ferry-Dumazet H., Groppi A.,
RA   Hantraye F., Hennequin C., Jauniaux N., Joyet P., Kachouri R.,
RA   Kerrest A., Koszul R., Lemaire M., Lesur I., Ma L., Muller H.,
RA   Nicaud J.-M., Nikolski M., Oztas S., Ozier-Kalogeropoulos O.,
RA   Pellenz S., Potier S., Richard G.-F., Straub M.-L., Suleau A.,
RA   Swennen D., Tekaia F., Wesolowski-Louvel M., Westhof E., Wirth B.,
RA   Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M., Thierry A.,
RA   Bouchier C., Caudron B., Scarpelli C., Gaillardin C., Weissenbach J.,
RA   Wincker P., Souciet J.-L.;
RT   "Genome evolution in yeasts.";
RL   Nature 430:35-44(2004).
CC   -!- FUNCTION: Involved in the import of nuclear-targeted proteins into
CC       the nucleus and the export of poly(A) RNA out of the nucleus. Has
CC       a role in the endoplasmic reticulum-associated degradation (ERAD)
CC       pathway (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, perinuclear region {ECO:0000250}.
CC       Endoplasmic reticulum membrane {ECO:0000250}; Peripheral membrane
CC       protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Nucleus
CC       membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250};
CC       Cytoplasmic side {ECO:0000250}. Note=Localizes mainly at the
CC       nuclear periphery and the endoplasmic reticulum membrane.
CC       {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the NPL4 family. {ECO:0000305}.
DR   EMBL; CR380959; CAG62588.1; -; Genomic_DNA.
DR   RefSeq; XP_449612.1; XM_449612.1.
DR   ProteinModelPortal; Q6FJI2; -.
DR   STRING; 284593.XP_449612.1; -.
DR   PRIDE; Q6FJI2; -.
DR   EnsemblFungi; CAG62588; CAG62588; CAGL0M06105g.
DR   KEGG; cgr:CAGL0M06105g; -.
DR   CGD; CAL0137323; CAGL0M06105g.
DR   EuPathDB; FungiDB:CAGL0M06105g; -.
DR   eggNOG; KOG2834; Eukaryota.
DR   eggNOG; COG5100; LUCA.
DR   HOGENOM; HOG000008139; -.
DR   InParanoid; Q6FJI2; -.
DR   KO; K14015; -.
DR   OMA; IKHGDML; -.
DR   OrthoDB; EOG092C0UR7; -.
DR   Proteomes; UP000002428; Chromosome M.
DR   GO; GO:0036266; C:Cdc48p-Npl4p-Vms1p AAA ATPase complex; IEA:EnsemblFungi.
DR   GO; GO:0000837; C:Doa10p ubiquitin ligase complex; IEA:EnsemblFungi.
DR   GO; GO:0000839; C:Hrd1p ubiquitin ligase ERAD-L complex; IEA:EnsemblFungi.
DR   GO; GO:0031965; C:nuclear membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0048471; C:perinuclear region of cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:1990112; C:RQC complex; IEA:EnsemblFungi.
DR   GO; GO:0034098; C:VCP-NPL4-UFD1 AAA ATPase complex; IEA:EnsemblFungi.
DR   GO; GO:0071712; P:ER-associated misfolded protein catabolic process; IEA:EnsemblFungi.
DR   GO; GO:0072671; P:mitochondria-associated ubiquitin-dependent protein catabolic process; IEA:EnsemblFungi.
DR   GO; GO:0051228; P:mitotic spindle disassembly; IEA:EnsemblFungi.
DR   GO; GO:0051028; P:mRNA transport; IEA:UniProtKB-KW.
DR   GO; GO:0051974; P:negative regulation of telomerase activity; IEA:EnsemblFungi.
DR   GO; GO:0070651; P:nonfunctional rRNA decay; IEA:EnsemblFungi.
DR   GO; GO:1900182; P:positive regulation of protein localization to nucleus; IEA:EnsemblFungi.
DR   GO; GO:0030970; P:retrograde protein transport, ER to cytosol; IEA:EnsemblFungi.
DR   GO; GO:1990116; P:ribosome-associated ubiquitin-dependent protein catabolic process; IEA:EnsemblFungi.
DR   GO; GO:0071629; P:ubiquitin-dependent catabolism of misfolded proteins by cytoplasm-associated proteasome; IEA:EnsemblFungi.
DR   GO; GO:0030433; P:ubiquitin-dependent ERAD pathway; IEA:EnsemblFungi.
DR   CDD; cd08061; MPN_NPL4; 1.
DR   InterPro; IPR016563; Npl4.
DR   InterPro; IPR007717; NPL4_C.
DR   InterPro; IPR024682; Npl4_Ub-like_dom.
DR   InterPro; IPR007716; NPL4_Zn-bd_put.
DR   InterPro; IPR029071; Ubiquitin-rel_dom.
DR   Pfam; PF05021; NPL4; 1.
DR   Pfam; PF11543; UN_NPL4; 1.
DR   Pfam; PF05020; zf-NPL4; 1.
DR   PIRSF; PIRSF010052; Polyub_prc_Npl4; 1.
DR   SUPFAM; SSF54236; SSF54236; 1.
PE   3: Inferred from homology;
DR   PRODOM; Q6FJI2.
DR   SWISS-2DPAGE; Q6FJI2.
KW   Complete proteome; Cytoplasm; Endoplasmic reticulum; Membrane;
KW   mRNA transport; Nucleus; Protein transport; Reference proteome;
KW   Translocation; Transport.
FT   CHAIN         1    580       Nuclear protein localization protein 4.
FT                                /FTId=PRO_0000339440.
SQ   SEQUENCE   580 AA;  65349 MW;  197DADFBE42E2B88 CRC64;
     MIIRFRSPVG MHRVRCEGSE TLGQVLPQLQ TILNEHGITP RAIELGKEAN GKDKTNVESL
     LEKTIEALGF RHGDIVYVHY QVDSSETKGS ANDNNGSVAV NIPNNLVPGK SQKADELEVD
     KELEKLDGLI PRQKTKLCKH GDRGMCEYCS PLPPWDANYA NENNIKHISF HAYLKKLNES
     TNKRESGSSY IAPLSQPNFK INKHCTNGHE PWPKGICSKC QPSAITLQQQ EFRMVDHVEF
     QSSELINQFI EFWRASGTQR FAYLYGKYEK YDATPLGIKA CVHAIYEPPQ HDEQDGITMD
     MEQVTQELNT IDLLAKEMGL LRVGMIFSDL TDAGNGDGTV LCKRHKDSFF LSSLETIMAA
     QHQTRHPNVS KFSEQGIFSS KFVTCVVSGN LKEEIDIASY QVSIDAEALV SADMIGGSTH
     PSMAYINDTT EDRYVPEIFY MKKNEYGLTV KENAKPAFPV DYLIVSLTHG FPKDEDTTTQ
     LFNSVTGFPW SNRQAMGYSQ DYHELKRYLH STAASGNFND LHDKLANFHL LLYIHSLQIL
     SQEEWELLVK GALSQDYQEP LYKLSASPGW QTLLMIIESA
//

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