(data stored in ACNUC8465 zone)

SWISSPROT: Q6FJH7_CANGA

ID   Q6FJH7_CANGA            Unreviewed;       317 AA.
AC   Q6FJH7;
DT   19-JUL-2004, integrated into UniProtKB/TrEMBL.
DT   19-JUL-2004, sequence version 1.
DT   30-AUG-2017, entry version 90.
DE   RecName: Full=3-methyl-2-oxobutanoate hydroxymethyltransferase {ECO:0000256|RuleBase:RU362100};
DE            EC=2.1.2.11 {ECO:0000256|RuleBase:RU362100};
GN   OrderedLocusNames=CAGL0M06215g {ECO:0000313|CGD:CAL0137239,
GN   ECO:0000313|EMBL:CAG62593.1};
OS   Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 /
OS   NRRL Y-65) (Yeast) (Torulopsis glabrata).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina;
OC   Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Nakaseomyces;
OC   Nakaseomyces/Candida clade.
OX   NCBI_TaxID=284593 {ECO:0000313|Proteomes:UP000002428};
RN   [1] {ECO:0000313|EMBL:CAG62593.1, ECO:0000313|Proteomes:UP000002428}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65
RC   {ECO:0000313|Proteomes:UP000002428};
RX   PubMed=15229592; DOI=10.1038/nature02579;
RG   Genolevures;
RA   Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S.,
RA   Lafontaine I., de Montigny J., Marck C., Neuveglise C., Talla E.,
RA   Goffard N., Frangeul L., Aigle M., Anthouard V., Babour A., Barbe V.,
RA   Barnay S., Blanchin S., Beckerich J.M., Beyne E., Bleykasten C.,
RA   Boisrame A., Boyer J., Cattolico L., Confanioleri F., de Daruvar A.,
RA   Despons L., Fabre E., Fairhead C., Ferry-Dumazet H., Groppi A.,
RA   Hantraye F., Hennequin C., Jauniaux N., Joyet P., Kachouri R.,
RA   Kerrest A., Koszul R., Lemaire M., Lesur I., Ma L., Muller H.,
RA   Nicaud J.M., Nikolski M., Oztas S., Ozier-Kalogeropoulos O.,
RA   Pellenz S., Potier S., Richard G.F., Straub M.L., Suleau A.,
RA   Swennene D., Tekaia F., Wesolowski-Louvel M., Westhof E., Wirth B.,
RA   Zeniou-Meyer M., Zivanovic I., Bolotin-Fukuhara M., Thierry A.,
RA   Bouchier C., Caudron B., Scarpelli C., Gaillardin C., Weissenbach J.,
RA   Wincker P., Souciet J.L.;
RT   "Genome evolution in yeasts.";
RL   Nature 430:35-44(2004).
CC   -!- FUNCTION: Catalyzes the reversible reaction in which hydroxymethyl
CC       group from 5,10-methylenetetrahydrofolate is transferred onto
CC       alpha-ketoisovalerate to form ketopantoate.
CC       {ECO:0000256|RuleBase:RU362100}.
CC   -!- CATALYTIC ACTIVITY: 5,10-methylenetetrahydrofolate + 3-methyl-2-
CC       oxobutanoate + H(2)O = tetrahydrofolate + 2-dehydropantoate.
CC       {ECO:0000256|RuleBase:RU362100}.
CC   -!- PATHWAY: Cofactor biosynthesis; (R)-pantothenate biosynthesis;
CC       (R)-pantoate from 3-methyl-2-oxobutanoate: step 1/2.
CC       {ECO:0000256|RuleBase:RU362100}.
CC   -!- SIMILARITY: Belongs to the PanB family.
CC       {ECO:0000256|RuleBase:RU362100}.
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DR   EMBL; CR380959; CAG62593.1; -; Genomic_DNA.
DR   RefSeq; XP_449617.1; XM_449617.1.
DR   ProteinModelPortal; Q6FJH7; -.
DR   STRING; 284593.XP_449617.1; -.
DR   EnsemblFungi; CAG62593; CAG62593; CAGL0M06215g.
DR   KEGG; cgr:CAGL0M06215g; -.
DR   CGD; CAL0137239; CAGL0M06215g.
DR   EuPathDB; FungiDB:CAGL0M06215g; -.
DR   eggNOG; KOG2949; Eukaryota.
DR   eggNOG; COG0413; LUCA.
DR   HOGENOM; HOG000078427; -.
DR   InParanoid; Q6FJH7; -.
DR   KO; K00606; -.
DR   OMA; GHIGLMP; -.
DR   OrthoDB; EOG092C3I9E; -.
DR   UniPathway; UPA00028; UER00003.
DR   Proteomes; UP000002428; Chromosome M.
DR   GO; GO:0005739; C:mitochondrion; IEA:EnsemblFungi.
DR   GO; GO:0003864; F:3-methyl-2-oxobutanoate hydroxymethyltransferase activity; IEA:UniProtKB-EC.
DR   GO; GO:0015940; P:pantothenate biosynthetic process; IEA:UniProtKB-UniPathway.
DR   CDD; cd06557; KPHMT-like; 1.
DR   HAMAP; MF_00156; PanB; 1.
DR   InterPro; IPR003700; Pantoate_hydroxy_MeTrfase.
DR   InterPro; IPR015813; Pyrv/PenolPyrv_Kinase-like_dom.
DR   PANTHER; PTHR20881; PTHR20881; 1.
DR   Pfam; PF02548; Pantoate_transf; 1.
DR   PIRSF; PIRSF000388; Pantoate_hydroxy_MeTrfase; 1.
DR   SUPFAM; SSF51621; SSF51621; 1.
DR   TIGRFAMs; TIGR00222; panB; 1.
PE   3: Inferred from homology;
DR   PRODOM; Q6FJH7.
DR   SWISS-2DPAGE; Q6FJH7.
KW   Complete proteome {ECO:0000313|Proteomes:UP000002428};
KW   Pantothenate biosynthesis {ECO:0000256|RuleBase:RU362100};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002428};
KW   Transferase {ECO:0000256|RuleBase:RU362100}.
SQ   SEQUENCE   317 AA;  34884 MW;  838E9913FEC4B60B CRC64;
     MMMLNRLKCL GKGPLRFYSV HSDTAGATKT ILDLQRKYVE RKPLTMCTAY DFITASWVQK
     ADTDILLIGD SMGMTSLGYD STSSLTLDEF KYHVKSVCRA EGPSFIVSDM PFGSFETSIS
     QGIQTAIDLM RSSSKVKSMK IESGSCHSDH HTYKLIGELC SRGIPVMGHI GLTPQRQHSL
     GGFKVQANKS VQEIHDLLAS AKKLEELGCW GIVLECIPQR VAGFITKALS IPTIGIGAGN
     QTSGQVLVVS DLLGFLDSTP PKFVKEYDNL GQRAIDSIKA YNSDVTTKAF PETGKHNFKI
     KEDIWNQFLS EVKVDKT
//

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