(data stored in ACNUC8465 zone)

SWISSPROT: BRO1_CANGA

ID   BRO1_CANGA              Reviewed;         888 AA.
AC   Q6FJG8;
DT   06-DEC-2005, integrated into UniProtKB/Swiss-Prot.
DT   19-JUL-2004, sequence version 1.
DT   08-MAY-2019, entry version 81.
DE   RecName: Full=Vacuolar protein-sorting protein BRO1;
DE   AltName: Full=BRO domain-containing protein 1;
GN   Name=BRO1; OrderedLocusNames=CAGL0M06413g;
OS   Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 /
OS   NRRL Y-65) (Yeast) (Torulopsis glabrata).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina;
OC   Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Nakaseomyces;
OC   Nakaseomyces/Candida clade.
OX   NCBI_TaxID=284593;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65;
RX   PubMed=15229592; DOI=10.1038/nature02579;
RA   Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S.,
RA   Lafontaine I., de Montigny J., Marck C., Neuveglise C., Talla E.,
RA   Goffard N., Frangeul L., Aigle M., Anthouard V., Babour A., Barbe V.,
RA   Barnay S., Blanchin S., Beckerich J.-M., Beyne E., Bleykasten C.,
RA   Boisrame A., Boyer J., Cattolico L., Confanioleri F., de Daruvar A.,
RA   Despons L., Fabre E., Fairhead C., Ferry-Dumazet H., Groppi A.,
RA   Hantraye F., Hennequin C., Jauniaux N., Joyet P., Kachouri R.,
RA   Kerrest A., Koszul R., Lemaire M., Lesur I., Ma L., Muller H.,
RA   Nicaud J.-M., Nikolski M., Oztas S., Ozier-Kalogeropoulos O.,
RA   Pellenz S., Potier S., Richard G.-F., Straub M.-L., Suleau A.,
RA   Swennen D., Tekaia F., Wesolowski-Louvel M., Westhof E., Wirth B.,
RA   Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M., Thierry A.,
RA   Bouchier C., Caudron B., Scarpelli C., Gaillardin C., Weissenbach J.,
RA   Wincker P., Souciet J.-L.;
RT   "Genome evolution in yeasts.";
RL   Nature 430:35-44(2004).
CC   -!- FUNCTION: Involved in concentration and sorting of cargo proteins
CC       of the multivesicular body (MVB) for incorporation into
CC       intralumenal vesicles. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Endosome
CC       {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the BRO1 family. {ECO:0000305}.
DR   EMBL; CR380959; CAG62602.1; -; Genomic_DNA.
DR   RefSeq; XP_449626.1; XM_449626.1.
DR   SMR; Q6FJG8; -.
DR   STRING; 5478.XP_449626.1; -.
DR   PRIDE; Q6FJG8; -.
DR   EnsemblFungi; CAG62602; CAG62602; CAGL0M06413g.
DR   GeneID; 2891674; -.
DR   KEGG; cgr:CAGL0M06413g; -.
DR   CGD; CAL0137439; CAGL0M06413g.
DR   EuPathDB; FungiDB:CAGL0M06413g; -.
DR   eggNOG; KOG2220; Eukaryota.
DR   eggNOG; ENOG410XQX6; LUCA.
DR   HOGENOM; HOG000095264; -.
DR   InParanoid; Q6FJG8; -.
DR   OMA; TWFDAFT; -.
DR   Proteomes; UP000002428; Chromosome M.
DR   GO; GO:0010008; C:endosome membrane; IEA:GOC.
DR   GO; GO:0035800; F:deubiquitinase activator activity; IEA:EnsemblFungi.
DR   GO; GO:1904669; P:ATP export; IEA:EnsemblFungi.
DR   GO; GO:0070676; P:intralumenal vesicle formation; IEA:EnsemblFungi.
DR   GO; GO:0072671; P:mitochondria-associated ubiquitin-dependent protein catabolic process; IEA:EnsemblFungi.
DR   GO; GO:0016579; P:protein deubiquitination; IEA:EnsemblFungi.
DR   GO; GO:0036010; P:protein localization to endosome; IEA:EnsemblFungi.
DR   GO; GO:0043328; P:protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway; IEA:EnsemblFungi.
DR   GO; GO:0007584; P:response to nutrient; IEA:EnsemblFungi.
DR   Gene3D; 1.25.40.280; -; 1.
DR   InterPro; IPR025304; ALIX_V_dom.
DR   InterPro; IPR004328; BRO1_dom.
DR   InterPro; IPR038499; BRO1_sf.
DR   Pfam; PF13949; ALIX_LYPXL_bnd; 1.
DR   Pfam; PF03097; BRO1; 1.
DR   SMART; SM01041; BRO1; 1.
DR   PROSITE; PS51180; BRO1; 1.
PE   3: Inferred from homology;
DR   PRODOM; Q6FJG8.
DR   SWISS-2DPAGE; Q6FJG8.
KW   Coiled coil; Complete proteome; Cytoplasm; Endosome;
KW   Protein transport; Reference proteome; Transport.
FT   CHAIN         1    888       Vacuolar protein-sorting protein BRO1.
FT                                /FTId=PRO_0000218862.
FT   DOMAIN        4    400       BRO1. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00526}.
FT   COILED      543    578       {ECO:0000255}.
FT   COMPBIAS    726    843       Pro-rich.
SQ   SEQUENCE   888 AA;  101130 MW;  606D93E4A5DF3D98 CRC64;
     MKPSVIGLKC KDTDKVDWKR GLSSYLKRIY GSRQWKEFYD EQLCVEMDHV RNNANGELGA
     VTLVEQNYKY YAYLEQLYLR LGNNIGQFKL EFTWYDAEYG LVSSPTKHTQ KTLVFEKSCT
     LYNLGVALTE VANEKINEDF KTAMVHMAKA MECFRYLSEN FFNSPSADLQ TENTKFLSDL
     SHAEAQEMFL INAINNGTSE KQASLISKLA YSGSNLYENC WEFLRTEEGG LTPYGEARWN
     SIVSGKHHFF RSLAAYYNAL ALEQNNKYGE AIAFLKLATQ CLSSSLPYKY ALNDNFDFDG
     FGETIKDKTK QLIKDNDYIF HDSIPQSVSL SSIKALDAIK APKWEEQLKP FMEAIAHKCE
     KLYRGIVPME VFEKESIYSE KKASMLRQCI NDSETADMEY SSFIEFTHLP NLLSDLKRRY
     KSQNFSGTTD PQGDMMRDQI QSWIKSISQS KYKDPDEQLK LISSKKQEIL TLLAGLPSEQ
     KENVVKLKMA LVEAAASDEK LFSLVQPYAA QLRLLKQPDE LWKIFNMFSI DESNKQSLLD
     IDDSKNQEIL AKISDIEQMA EDLRLLKEER GRTLKELKSQ TNDDDITNTL LVNSKAESEE
     LEVIFKKELD KFKPLTTRIE ATIFKQESVV NEVKNELDNV FSLSGLENKT SEEEEKQKKR
     KEFFMQIEEA ATKFLIFNND LPKGLEFYDS LLKMSKDLAV SVKVQNNASG SDNNSNNGYV
     SGNVIPPSLP PQPRNVGSSI DSQFQSMNLG SVPTPQRFPQ PPAPNSRPIV SMENYTSQFS
     VPPAHGDLPP AYNQVPLVPT RNYDQPHGSG NYPGNVSSQH PVSSSPIPGA YDQVPMVPPK
     QPPAEGRSQI SRQEQMEREE RELQRDPTAF YKKSSVFDES LYSRYSGK
//

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