(data stored in ACNUC8465 zone)

SWISSPROT: H4_CANGA

ID   H4_CANGA                Reviewed;         103 AA.
AC   Q8NIG3;
DT   31-AUG-2004, integrated into UniProtKB/Swiss-Prot.
DT   23-JAN-2007, sequence version 3.
DT   30-AUG-2017, entry version 89.
DE   RecName: Full=Histone H4;
GN   Name=HHF1; OrderedLocusNames=CAGL0C04136g;
GN   and
GN   Name=HHF2; OrderedLocusNames=CAGL0H09834g;
GN   and
GN   Name=HHF3; OrderedLocusNames=CAGL0M06677g;
OS   Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 /
OS   NRRL Y-65) (Yeast) (Torulopsis glabrata).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina;
OC   Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Nakaseomyces;
OC   Nakaseomyces/Candida clade.
OX   NCBI_TaxID=284593;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65;
RX   PubMed=12093907; DOI=10.1073/pnas.142101099;
RA   Wong S., Butler G., Wolfe K.H.;
RT   "Gene order evolution and paleopolyploidy in hemiascomycete yeasts.";
RL   Proc. Natl. Acad. Sci. U.S.A. 99:9272-9277(2002).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65;
RX   PubMed=15229592; DOI=10.1038/nature02579;
RA   Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S.,
RA   Lafontaine I., de Montigny J., Marck C., Neuveglise C., Talla E.,
RA   Goffard N., Frangeul L., Aigle M., Anthouard V., Babour A., Barbe V.,
RA   Barnay S., Blanchin S., Beckerich J.-M., Beyne E., Bleykasten C.,
RA   Boisrame A., Boyer J., Cattolico L., Confanioleri F., de Daruvar A.,
RA   Despons L., Fabre E., Fairhead C., Ferry-Dumazet H., Groppi A.,
RA   Hantraye F., Hennequin C., Jauniaux N., Joyet P., Kachouri R.,
RA   Kerrest A., Koszul R., Lemaire M., Lesur I., Ma L., Muller H.,
RA   Nicaud J.-M., Nikolski M., Oztas S., Ozier-Kalogeropoulos O.,
RA   Pellenz S., Potier S., Richard G.-F., Straub M.-L., Suleau A.,
RA   Swennen D., Tekaia F., Wesolowski-Louvel M., Westhof E., Wirth B.,
RA   Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M., Thierry A.,
RA   Bouchier C., Caudron B., Scarpelli C., Gaillardin C., Weissenbach J.,
RA   Wincker P., Souciet J.-L.;
RT   "Genome evolution in yeasts.";
RL   Nature 430:35-44(2004).
CC   -!- FUNCTION: Core component of nucleosome. Nucleosomes wrap and
CC       compact DNA into chromatin, limiting DNA accessibility to the
CC       cellular machineries which require DNA as a template. Histones
CC       thereby play a central role in transcription regulation, DNA
CC       repair, DNA replication and chromosomal stability. DNA
CC       accessibility is regulated via a complex set of post-translational
CC       modifications of histones, also called histone code, and
CC       nucleosome remodeling (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: The nucleosome is a histone octamer containing two
CC       molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4
CC       heterotetramer and two H2A-H2B heterodimers. The octamer wraps
CC       approximately 147 bp of DNA (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Chromosome
CC       {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the histone H4 family. {ECO:0000305}.
DR   EMBL; AF520060; AAM74210.1; -; Genomic_DNA.
DR   EMBL; AF520061; AAM74216.1; -; Genomic_DNA.
DR   EMBL; CR380949; CAG58261.1; -; Genomic_DNA.
DR   EMBL; CR380954; CAG60158.1; -; Genomic_DNA.
DR   EMBL; CR380959; CAG62614.1; -; Genomic_DNA.
DR   RefSeq; XP_445355.1; XM_445355.1.
DR   RefSeq; XP_447225.1; XM_447225.1.
DR   RefSeq; XP_449638.1; XM_449638.1.
DR   ProteinModelPortal; Q8NIG3; -.
DR   SMR; Q8NIG3; -.
DR   STRING; 284593.XP_449638.1; -.
DR   PRIDE; Q8NIG3; -.
DR   EnsemblFungi; CAG58261; CAG58261; CAGL0C04136g.
DR   EnsemblFungi; CAG60158; CAG60158; CAGL0H09834g.
DR   EnsemblFungi; CAG62614; CAG62614; CAGL0M06677g.
DR   KEGG; cgr:CAGL0C04136g; -.
DR   KEGG; cgr:CAGL0H09834g; -.
DR   KEGG; cgr:CAGL0M06677g; -.
DR   CGD; CAL0127348; CAGL0C04136g.
DR   CGD; CAL0131500; CAGL0H09834g.
DR   CGD; CAL0136709; CAGL0M06677g.
DR   eggNOG; KOG3467; Eukaryota.
DR   eggNOG; COG2036; LUCA.
DR   HOGENOM; HOG000234654; -.
DR   InParanoid; Q8NIG3; -.
DR   KO; K11254; -.
DR   OMA; YEEVRVV; -.
DR   OrthoDB; EOG092C5WME; -.
DR   Proteomes; UP000002428; Chromosome C.
DR   Proteomes; UP000002428; Chromosome H.
DR   Proteomes; UP000002428; Chromosome M.
DR   GO; GO:0000786; C:nucleosome; IEA:UniProtKB-KW.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0046982; F:protein heterodimerization activity; IEA:InterPro.
DR   GO; GO:0006334; P:nucleosome assembly; IEA:InterPro.
DR   CDD; cd00076; H4; 1.
DR   InterPro; IPR035425; CENP-T/H4_C.
DR   InterPro; IPR009072; Histone-fold.
DR   InterPro; IPR001951; Histone_H4.
DR   InterPro; IPR019809; Histone_H4_CS.
DR   Pfam; PF15511; CENP-T_C; 1.
DR   PRINTS; PR00623; HISTONEH4.
DR   SMART; SM00417; H4; 1.
DR   SUPFAM; SSF47113; SSF47113; 1.
DR   PROSITE; PS00047; HISTONE_H4; 1.
PE   3: Inferred from homology;
DR   PRODOM; Q8NIG3.
DR   SWISS-2DPAGE; Q8NIG3.
KW   Chromosome; Complete proteome; DNA-binding; Nucleosome core; Nucleus;
KW   Reference proteome.
FT   INIT_MET      1      1       Removed. {ECO:0000250}.
FT   CHAIN         2    103       Histone H4.
FT                                /FTId=PRO_0000158292.
FT   DNA_BIND     17     21
SQ   SEQUENCE   103 AA;  11352 MW;  69AE3666FE62DE41 CRC64;
     MSGRGKGGKG LGKGGAKRHR KILRDNIQGI TKPAIRRLAR RGGVKRISGL IYEEVRAVLK
     SFLESVIRDA VTYTEHAKRK TVTSLDVVYA LKRQGRTLYG FGG
//

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