(data stored in ACNUC8465 zone)

SWISSPROT: SSN8_CANGA

ID   SSN8_CANGA              Reviewed;         339 AA.
AC   Q6FJE8;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   19-JUL-2004, sequence version 1.
DT   30-AUG-2017, entry version 90.
DE   RecName: Full=RNA polymerase II holoenzyme cyclin-like subunit;
GN   Name=SSN8; OrderedLocusNames=CAGL0M06875g;
OS   Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 /
OS   NRRL Y-65) (Yeast) (Torulopsis glabrata).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina;
OC   Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Nakaseomyces;
OC   Nakaseomyces/Candida clade.
OX   NCBI_TaxID=284593;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65;
RX   PubMed=15229592; DOI=10.1038/nature02579;
RA   Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S.,
RA   Lafontaine I., de Montigny J., Marck C., Neuveglise C., Talla E.,
RA   Goffard N., Frangeul L., Aigle M., Anthouard V., Babour A., Barbe V.,
RA   Barnay S., Blanchin S., Beckerich J.-M., Beyne E., Bleykasten C.,
RA   Boisrame A., Boyer J., Cattolico L., Confanioleri F., de Daruvar A.,
RA   Despons L., Fabre E., Fairhead C., Ferry-Dumazet H., Groppi A.,
RA   Hantraye F., Hennequin C., Jauniaux N., Joyet P., Kachouri R.,
RA   Kerrest A., Koszul R., Lemaire M., Lesur I., Ma L., Muller H.,
RA   Nicaud J.-M., Nikolski M., Oztas S., Ozier-Kalogeropoulos O.,
RA   Pellenz S., Potier S., Richard G.-F., Straub M.-L., Suleau A.,
RA   Swennen D., Tekaia F., Wesolowski-Louvel M., Westhof E., Wirth B.,
RA   Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M., Thierry A.,
RA   Bouchier C., Caudron B., Scarpelli C., Gaillardin C., Weissenbach J.,
RA   Wincker P., Souciet J.-L.;
RT   "Genome evolution in yeasts.";
RL   Nature 430:35-44(2004).
CC   -!- FUNCTION: Component of the SRB8-11 complex. The SRB8-11 complex is
CC       a regulatory module of the Mediator complex which is itself
CC       involved in regulation of basal and activated RNA polymerase II-
CC       dependent transcription. The SRB8-11 complex may be involved in
CC       the transcriptional repression of a subset of genes regulated by
CC       Mediator. It may inhibit the association of the Mediator complex
CC       with RNA polymerase II to form the holoenzyme complex. The SRB8-11
CC       complex phosphorylates the C-terminal domain (CTD) of the largest
CC       subunit of RNA polymerase II (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Component of the SRB8-11 complex, a regulatory module of
CC       the Mediator complex. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the cyclin family. Cyclin C subfamily.
CC       {ECO:0000305}.
DR   EMBL; CR380959; CAG62622.1; -; Genomic_DNA.
DR   RefSeq; XP_449646.1; XM_449646.1.
DR   ProteinModelPortal; Q6FJE8; -.
DR   STRING; 284593.XP_449646.1; -.
DR   EnsemblFungi; CAG62622; CAG62622; CAGL0M06875g.
DR   KEGG; cgr:CAGL0M06875g; -.
DR   CGD; CAL0136591; CAGL0M06875g.
DR   EuPathDB; FungiDB:CAGL0M06875g; -.
DR   eggNOG; KOG0794; Eukaryota.
DR   eggNOG; COG5333; LUCA.
DR   HOGENOM; HOG000217621; -.
DR   InParanoid; Q6FJE8; -.
DR   KO; K15161; -.
DR   OMA; FWASSHY; -.
DR   OrthoDB; EOG092C2LUP; -.
DR   Proteomes; UP000002428; Chromosome M.
DR   GO; GO:0016592; C:mediator complex; IEA:EnsemblFungi.
DR   GO; GO:0016538; F:cyclin-dependent protein serine/threonine kinase regulator activity; IEA:EnsemblFungi.
DR   GO; GO:0000979; F:RNA polymerase II core promoter sequence-specific DNA binding; IEA:EnsemblFungi.
DR   GO; GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; IEA:EnsemblFungi.
DR   GO; GO:0000411; P:positive regulation of transcription by galactose; IEA:EnsemblFungi.
DR   GO; GO:0010673; P:positive regulation of transcription from RNA polymerase II promoter involved in meiotic cell cycle; IEA:EnsemblFungi.
DR   GO; GO:0006351; P:transcription, DNA-templated; IEA:UniProtKB-KW.
DR   Gene3D; 1.10.472.10; -; 2.
DR   InterPro; IPR013763; Cyclin-like.
DR   InterPro; IPR006671; Cyclin_N.
DR   InterPro; IPR028367; CyclinC/Ssn8.
DR   PANTHER; PTHR10026:SF86; PTHR10026:SF86; 1.
DR   Pfam; PF00134; Cyclin_N; 1.
DR   SMART; SM00385; CYCLIN; 1.
DR   SUPFAM; SSF47954; SSF47954; 2.
PE   3: Inferred from homology;
DR   PRODOM; Q6FJE8.
DR   SWISS-2DPAGE; Q6FJE8.
KW   Activator; Complete proteome; Cyclin; Nucleus; Reference proteome;
KW   Repressor; Transcription; Transcription regulation.
FT   CHAIN         1    339       RNA polymerase II holoenzyme cyclin-like
FT                                subunit.
FT                                /FTId=PRO_0000314271.
FT   DOMAIN       93    194       Cyclin N-terminal.
SQ   SEQUENCE   339 AA;  39489 MW;  E87764C7319927E3 CRC64;
     MSGSYWTSMQ RQKWQHTKPS LARERQRLWV MECQLFPQGL NIIVDSKPNS ADSSNGNAAN
     NGGGNGRSQL VATTKNIPIT HRDLHYDKDY NLRIYCYFLI MKLGRRLNIR QYALATAHIY
     LSRFLLKASV REVNLYLLVT TCVYLACKVE ECPQYIRTLV SEARSLWPEF IPPDPTKVTE
     FEFYLIEELQ CYLIVHHPYK SMEQIVEALK EEPFKLTFTS DELQNCWSLI NDSFINDVHL
     TYAPHIIAMA CLFITVSIQG SNTKELSLTS AVTETLTSQS SLTPQQQTFF RFLAESHVDL
     EEVMDTIQQQ IILYDHWDRY HEPWIKYLLH TLYLRPLSA
//

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