(data stored in ACNUC8465 zone)

SWISSPROT: LPE10_CANGA

ID   LPE10_CANGA             Reviewed;         397 AA.
AC   Q6FJD1;
DT   06-DEC-2005, integrated into UniProtKB/Swiss-Prot.
DT   19-JUL-2004, sequence version 1.
DT   30-AUG-2017, entry version 80.
DE   RecName: Full=Mitochondrial inner membrane magnesium transporter LPE10;
DE   Flags: Precursor;
GN   Name=LPE10; OrderedLocusNames=CAGL0M07249g;
OS   Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 /
OS   NRRL Y-65) (Yeast) (Torulopsis glabrata).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina;
OC   Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Nakaseomyces;
OC   Nakaseomyces/Candida clade.
OX   NCBI_TaxID=284593;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65;
RX   PubMed=15229592; DOI=10.1038/nature02579;
RA   Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S.,
RA   Lafontaine I., de Montigny J., Marck C., Neuveglise C., Talla E.,
RA   Goffard N., Frangeul L., Aigle M., Anthouard V., Babour A., Barbe V.,
RA   Barnay S., Blanchin S., Beckerich J.-M., Beyne E., Bleykasten C.,
RA   Boisrame A., Boyer J., Cattolico L., Confanioleri F., de Daruvar A.,
RA   Despons L., Fabre E., Fairhead C., Ferry-Dumazet H., Groppi A.,
RA   Hantraye F., Hennequin C., Jauniaux N., Joyet P., Kachouri R.,
RA   Kerrest A., Koszul R., Lemaire M., Lesur I., Ma L., Muller H.,
RA   Nicaud J.-M., Nikolski M., Oztas S., Ozier-Kalogeropoulos O.,
RA   Pellenz S., Potier S., Richard G.-F., Straub M.-L., Suleau A.,
RA   Swennen D., Tekaia F., Wesolowski-Louvel M., Westhof E., Wirth B.,
RA   Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M., Thierry A.,
RA   Bouchier C., Caudron B., Scarpelli C., Gaillardin C., Weissenbach J.,
RA   Wincker P., Souciet J.-L.;
RT   "Genome evolution in yeasts.";
RL   Nature 430:35-44(2004).
CC   -!- FUNCTION: Mitochondrial inner membrane magnesium transporter
CC       required for mitochondrial magnesium homeostasis. Modulates the
CC       conductance of the MRS2 channel. Involved in the splicing of mRNA
CC       group II introns in mitochondria by affecting mitochondrial
CC       magnesium concentrations, which are critical for group II intron
CC       splicing. {ECO:0000250|UniProtKB:Q02783}.
CC   -!- SUBUNIT: Forms homooligomers. Interacts with MRS2.
CC       {ECO:0000250|UniProtKB:Q02783}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane
CC       {ECO:0000250|UniProtKB:Q02783}; Multi-pass membrane protein
CC       {ECO:0000250|UniProtKB:Q02783}.
CC   -!- SIMILARITY: Belongs to the CorA metal ion transporter (MIT)
CC       (TC 1.A.35) family. {ECO:0000305}.
DR   EMBL; CR380959; CAG62639.1; -; Genomic_DNA.
DR   RefSeq; XP_449663.1; XM_449663.1.
DR   ProteinModelPortal; Q6FJD1; -.
DR   SMR; Q6FJD1; -.
DR   EnsemblFungi; CAG62639; CAG62639; CAGL0M07249g.
DR   KEGG; cgr:CAGL0M07249g; -.
DR   CGD; CAL0136217; CAGL0M07249g.
DR   EuPathDB; FungiDB:CAGL0M07249g; -.
DR   eggNOG; ENOG410IS94; Eukaryota.
DR   eggNOG; ENOG410XRIZ; LUCA.
DR   HOGENOM; HOG000248323; -.
DR   InParanoid; Q6FJD1; -.
DR   KO; K16075; -.
DR   OMA; YHLEHNL; -.
DR   OrthoDB; EOG092C23OZ; -.
DR   Proteomes; UP000002428; Chromosome M.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0015095; F:magnesium ion transmembrane transporter activity; IEA:EnsemblFungi.
DR   GO; GO:0045016; P:mitochondrial magnesium ion transport; IEA:EnsemblFungi.
DR   InterPro; IPR002523; MgTranspt_CorA/ZnTranspt_ZntB.
DR   Pfam; PF01544; CorA; 1.
PE   3: Inferred from homology;
DR   PRODOM; Q6FJD1.
DR   SWISS-2DPAGE; Q6FJD1.
KW   Complete proteome; Ion transport; Magnesium; Membrane; Mitochondrion;
KW   Mitochondrion inner membrane; Reference proteome; Transit peptide;
KW   Transmembrane; Transmembrane helix; Transport.
FT   TRANSIT       1     37       Mitochondrion. {ECO:0000255}.
FT   CHAIN        38    397       Mitochondrial inner membrane magnesium
FT                                transporter LPE10.
FT                                /FTId=PRO_0000043237.
FT   TRANSMEM    316    336       Helical. {ECO:0000255}.
FT   TRANSMEM    354    374       Helical. {ECO:0000255}.
FT   MOTIF       340    343       YGMN.
SQ   SEQUENCE   397 AA;  45159 MW;  06940662E0AE8098 CRC64;
     MLLVNRAITL NLVKRCCWRS TMFMTPKRFL GTSEEESTAA LLLQKNLIQR NNMLYGHGSG
     TIRCTVFDAG GNIVSPALDI KREELVAKHG LLPRDLRKIE KSRKNDLVPS FLVRKNGILV
     SLATIKTLIK PDMVIVFDSF GSLNSTSHKA FLNSLKLRLQ NLDMVELKKD PLPYEFRALE
     SIFISALSNL TSEMNVQVTI CKGILQDLEY SITRDKLKFL LGQNKKLSNF YKKTVLIRDM
     LDDLLEQSDV LCSMYLSDLK NGVEHKDDDH SEIEMLLETY HNHLDEIVQI TENIISNVKT
     TEEIINIILD SNRNQLMLLG IRFSIGMLSL GGPIFIGSLY GMNLENFIEE TDYGFIAASA
     IGMISLGALY FYSIKHLHKL QKMSLFNYTN YARDVKK
//

If you have problems or comments...

PBIL Back to PBIL home page