(data stored in ACNUC8465 zone)

SWISSPROT: CSN12_CANGA

ID   CSN12_CANGA             Reviewed;         449 AA.
AC   Q6FJ48;
DT   06-DEC-2005, integrated into UniProtKB/Swiss-Prot.
DT   19-JUL-2004, sequence version 1.
DT   30-AUG-2017, entry version 66.
DE   RecName: Full=COP9 signalosome complex subunit 12;
GN   Name=CSN12; OrderedLocusNames=CAGL0M09251g;
OS   Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 /
OS   NRRL Y-65) (Yeast) (Torulopsis glabrata).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina;
OC   Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Nakaseomyces;
OC   Nakaseomyces/Candida clade.
OX   NCBI_TaxID=284593;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65;
RX   PubMed=15229592; DOI=10.1038/nature02579;
RA   Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S.,
RA   Lafontaine I., de Montigny J., Marck C., Neuveglise C., Talla E.,
RA   Goffard N., Frangeul L., Aigle M., Anthouard V., Babour A., Barbe V.,
RA   Barnay S., Blanchin S., Beckerich J.-M., Beyne E., Bleykasten C.,
RA   Boisrame A., Boyer J., Cattolico L., Confanioleri F., de Daruvar A.,
RA   Despons L., Fabre E., Fairhead C., Ferry-Dumazet H., Groppi A.,
RA   Hantraye F., Hennequin C., Jauniaux N., Joyet P., Kachouri R.,
RA   Kerrest A., Koszul R., Lemaire M., Lesur I., Ma L., Muller H.,
RA   Nicaud J.-M., Nikolski M., Oztas S., Ozier-Kalogeropoulos O.,
RA   Pellenz S., Potier S., Richard G.-F., Straub M.-L., Suleau A.,
RA   Swennen D., Tekaia F., Wesolowski-Louvel M., Westhof E., Wirth B.,
RA   Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M., Thierry A.,
RA   Bouchier C., Caudron B., Scarpelli C., Gaillardin C., Weissenbach J.,
RA   Wincker P., Souciet J.-L.;
RT   "Genome evolution in yeasts.";
RL   Nature 430:35-44(2004).
CC   -!- FUNCTION: Component of the COP9 signalosome (CSN) complex that
CC       acts as an regulator of the ubiquitin (Ubl) conjugation pathway by
CC       mediating the deneddylation of the cullin subunit of SCF-type E3
CC       ubiquitin-protein ligase complexes. The CSN complex is involved in
CC       the regulation of the mating pheromone response (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBUNIT: Component of a COP9 signalosome-like (CSN) complex.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus
CC       {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the CSN12 family. {ECO:0000305}.
DR   EMBL; CR380959; CAG62724.1; -; Genomic_DNA.
DR   RefSeq; XP_449746.1; XM_449746.1.
DR   STRING; 284593.XP_449746.1; -.
DR   EnsemblFungi; CAG62724; CAG62724; CAGL0M09251g.
DR   KEGG; cgr:CAGL0M09251g; -.
DR   CGD; CAL0136487; CAGL0M09251g.
DR   EuPathDB; FungiDB:CAGL0M09251g; -.
DR   eggNOG; KOG2688; Eukaryota.
DR   eggNOG; COG5600; LUCA.
DR   InParanoid; Q6FJ48; -.
DR   OMA; DIDETEC; -.
DR   OrthoDB; EOG092C4AHS; -.
DR   Proteomes; UP000002428; Chromosome M.
DR   GO; GO:0008180; C:COP9 signalosome; IEA:UniProtKB-KW.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   InterPro; IPR000717; PCI_dom.
DR   Pfam; PF01399; PCI; 1.
PE   3: Inferred from homology;
DR   PRODOM; Q6FJ48.
DR   SWISS-2DPAGE; Q6FJ48.
KW   Complete proteome; Cytoplasm; Nucleus; Reference proteome;
KW   Signalosome.
FT   CHAIN         1    449       COP9 signalosome complex subunit 12.
FT                                /FTId=PRO_0000121038.
FT   DOMAIN      316    441       PCI.
SQ   SEQUENCE   449 AA;  52648 MW;  50065C165F8673FD CRC64;
     MEYSRFVDCF ERRSYTAEFL EFVGFKLSSE PLGATALILG GSQAKQARYG DVNALYDAIV
     QIKLKESLTS LRELDPNAAV KKNKQRKVHQ RVVDVFQALT NELRILNKIL ERSDDSVWLV
     YPVYTVCHDV STFLRDTGKY MQLESRKQLW EECIRVIHRS FMICLNDKNP NMQENKRGGC
     ILFANLEMMF YKMLRNRDMM KNLIKVLEST GMTDISRQRD NKVLKRHRSQ KIIFNYFIGE
     YYGCYLFQFN KAQEHLQVCV SEFPVKYTSS KWFKRIIHLY TQFRMLATSN KLIHVELPRE
     TNEKFANAYD SDLMNKCYKN GDTIVFDELI KEHAAQYLID GTYSAMLLIK ELVFLRLVKV
     CYKVNDKKSI LPLDLIAAGY RIHFRNHDNE ENRVTTTNPR KLQKKNEDLL DELECRIANL
     IANGRIKGYL SHSQRCMVLS KTEPFPLAS
//

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