(data stored in ACNUC8465 zone)

SWISSPROT: ATG16_CANGA

ID   ATG16_CANGA             Reviewed;         108 AA.
AC   Q6FJ38;
DT   16-AUG-2005, integrated into UniProtKB/Swiss-Prot.
DT   19-JUL-2004, sequence version 1.
DT   30-AUG-2017, entry version 68.
DE   RecName: Full=Autophagy protein 16;
GN   Name=ATG16; OrderedLocusNames=CAGL0M09471g;
OS   Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 /
OS   NRRL Y-65) (Yeast) (Torulopsis glabrata).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina;
OC   Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Nakaseomyces;
OC   Nakaseomyces/Candida clade.
OX   NCBI_TaxID=284593;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65;
RX   PubMed=15229592; DOI=10.1038/nature02579;
RA   Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S.,
RA   Lafontaine I., de Montigny J., Marck C., Neuveglise C., Talla E.,
RA   Goffard N., Frangeul L., Aigle M., Anthouard V., Babour A., Barbe V.,
RA   Barnay S., Blanchin S., Beckerich J.-M., Beyne E., Bleykasten C.,
RA   Boisrame A., Boyer J., Cattolico L., Confanioleri F., de Daruvar A.,
RA   Despons L., Fabre E., Fairhead C., Ferry-Dumazet H., Groppi A.,
RA   Hantraye F., Hennequin C., Jauniaux N., Joyet P., Kachouri R.,
RA   Kerrest A., Koszul R., Lemaire M., Lesur I., Ma L., Muller H.,
RA   Nicaud J.-M., Nikolski M., Oztas S., Ozier-Kalogeropoulos O.,
RA   Pellenz S., Potier S., Richard G.-F., Straub M.-L., Suleau A.,
RA   Swennen D., Tekaia F., Wesolowski-Louvel M., Westhof E., Wirth B.,
RA   Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M., Thierry A.,
RA   Bouchier C., Caudron B., Scarpelli C., Gaillardin C., Weissenbach J.,
RA   Wincker P., Souciet J.-L.;
RT   "Genome evolution in yeasts.";
RL   Nature 430:35-44(2004).
CC   -!- FUNCTION: Stabilizes the ATG5-ATG12 conjugate which is necessary
CC       for autophagy. The ATG5-ATG12/ATG16 complex is required for
CC       efficient promotion of ATG8-conjugation to
CC       phosphatidylethanolamine and ATG8 localization to the pre-
CC       autophagosomal structure (PAS). Recruits also ATG3 to the PAS.
CC       Involved in endoplasmic reticulum-specific autophagic process and
CC       is essential for the survival of cells subjected to severe ER
CC       stress (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Homodimer (By similarity). Part of the ATG5-ATG12/ATG16
CC       complex. Several units of each may be present in this complex (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Preautophagosomal structure membrane
CC       {ECO:0000250|UniProtKB:Q03818}; Peripheral membrane protein
CC       {ECO:0000250|UniProtKB:Q03818}.
CC   -!- SIMILARITY: Belongs to the ATG16 family. {ECO:0000305}.
DR   EMBL; CR380959; CAG62734.1; -; Genomic_DNA.
DR   RefSeq; XP_449756.1; XM_449756.1.
DR   SMR; Q6FJ38; -.
DR   STRING; 284593.XP_449756.1; -.
DR   EnsemblFungi; CAG62734; CAG62734; CAGL0M09471g.
DR   KEGG; cgr:CAGL0M09471g; -.
DR   CGD; CAL0136947; CAGL0M09471g.
DR   EuPathDB; FungiDB:CAGL0M09471g; -.
DR   eggNOG; ENOG410J3DF; Eukaryota.
DR   eggNOG; ENOG4112DAV; LUCA.
DR   HOGENOM; HOG000034134; -.
DR   InParanoid; Q6FJ38; -.
DR   KO; K08340; -.
DR   OMA; EADIMNT; -.
DR   OrthoDB; EOG092C5PK2; -.
DR   Proteomes; UP000002428; Chromosome M.
DR   GO; GO:0034045; C:pre-autophagosomal structure membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0006914; P:autophagy; IEA:UniProtKB-KW.
DR   GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR   InterPro; IPR013923; Autophagy-rel_prot_16.
DR   Pfam; PF08614; ATG16; 1.
PE   3: Inferred from homology;
DR   PRODOM; Q6FJ38.
DR   SWISS-2DPAGE; Q6FJ38.
KW   Autophagy; Coiled coil; Complete proteome; Membrane;
KW   Protein transport; Reference proteome; Transport.
FT   CHAIN         1    108       Autophagy protein 16.
FT                                /FTId=PRO_0000218589.
FT   COILED       28     94       {ECO:0000255}.
SQ   SEQUENCE   108 AA;  12553 MW;  BBEBE8DEB869A806 CRC64;
     MLAERDTLEK NYCELFEVPV DGRSNDGDAM LLQEALRGKD NEIRMLEERL AVSSKNVERL
     NDELLGANLE ANVLGQKLQD LQQEHDKLLE RWMQRVRVEV DKMNAQLE
//

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