(data stored in ACNUC6288 zone)

SWISSPROT: IML1_DEBHA

ID   IML1_DEBHA              Reviewed;        1560 AA.
AC   Q6BN00;
DT   11-SEP-2007, integrated into UniProtKB/Swiss-Prot.
DT   16-DEC-2008, sequence version 2.
DT   08-MAY-2019, entry version 75.
DE   RecName: Full=Vacuolar membrane-associated protein IML1;
GN   Name=IML1; OrderedLocusNames=DEHA2F01320g;
OS   Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / JCM 1990 / NBRC
OS   0083 / IGC 2968) (Yeast) (Torulaspora hansenii).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina;
OC   Saccharomycetes; Saccharomycetales; Debaryomycetaceae; Debaryomyces.
OX   NCBI_TaxID=284592;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 36239 / CBS 767 / JCM 1990 / NBRC 0083 / IGC 2968;
RX   PubMed=15229592; DOI=10.1038/nature02579;
RA   Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S.,
RA   Lafontaine I., de Montigny J., Marck C., Neuveglise C., Talla E.,
RA   Goffard N., Frangeul L., Aigle M., Anthouard V., Babour A., Barbe V.,
RA   Barnay S., Blanchin S., Beckerich J.-M., Beyne E., Bleykasten C.,
RA   Boisrame A., Boyer J., Cattolico L., Confanioleri F., de Daruvar A.,
RA   Despons L., Fabre E., Fairhead C., Ferry-Dumazet H., Groppi A.,
RA   Hantraye F., Hennequin C., Jauniaux N., Joyet P., Kachouri R.,
RA   Kerrest A., Koszul R., Lemaire M., Lesur I., Ma L., Muller H.,
RA   Nicaud J.-M., Nikolski M., Oztas S., Ozier-Kalogeropoulos O.,
RA   Pellenz S., Potier S., Richard G.-F., Straub M.-L., Suleau A.,
RA   Swennen D., Tekaia F., Wesolowski-Louvel M., Westhof E., Wirth B.,
RA   Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M., Thierry A.,
RA   Bouchier C., Caudron B., Scarpelli C., Gaillardin C., Weissenbach J.,
RA   Wincker P., Souciet J.-L.;
RT   "Genome evolution in yeasts.";
RL   Nature 430:35-44(2004).
CC   -!- SUBCELLULAR LOCATION: Vacuole membrane {ECO:0000250}; Peripheral
CC       membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the IML1 family. {ECO:0000305}.
DR   EMBL; CR382138; CAG88724.2; -; Genomic_DNA.
DR   RefSeq; XP_460420.2; XM_460420.1.
DR   SMR; Q6BN00; -.
DR   STRING; 4959.XP_460420.2; -.
DR   PRIDE; Q6BN00; -.
DR   EnsemblFungi; CAG88724; CAG88724; DEHA2F01320g.
DR   GeneID; 2903820; -.
DR   KEGG; dha:DEHA2F01320g; -.
DR   HOGENOM; HOG000093241; -.
DR   InParanoid; Q6BN00; -.
DR   KO; K20404; -.
DR   OMA; VDRTWHF; -.
DR   OrthoDB; 45642at2759; -.
DR   Proteomes; UP000000599; Chromosome F.
DR   GO; GO:0097042; C:extrinsic component of fungal-type vacuolar membrane; IEA:EnsemblFungi.
DR   GO; GO:1990130; C:GATOR1 complex; IEA:EnsemblFungi.
DR   GO; GO:0005096; F:GTPase activator activity; IEA:EnsemblFungi.
DR   GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR   GO; GO:0051058; P:negative regulation of small GTPase mediated signal transduction; IEA:EnsemblFungi.
DR   GO; GO:1904262; P:negative regulation of TORC1 signaling; IEA:EnsemblFungi.
DR   GO; GO:0010508; P:positive regulation of autophagy; IEA:EnsemblFungi.
DR   GO; GO:2000785; P:regulation of autophagosome assembly; IEA:EnsemblFungi.
DR   Gene3D; 1.10.10.10; -; 1.
DR   InterPro; IPR000591; DEP_dom.
DR   InterPro; IPR027244; IML1.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   PANTHER; PTHR13179; PTHR13179; 1.
DR   Pfam; PF00610; DEP; 1.
DR   Pfam; PF12257; IML1; 1.
DR   SMART; SM00049; DEP; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   PROSITE; PS50186; DEP; 1.
PE   3: Inferred from homology;
DR   PRODOM; Q6BN00.
DR   SWISS-2DPAGE; Q6BN00.
KW   Complete proteome; Membrane; Reference proteome; Vacuole.
FT   CHAIN         1   1560       Vacuolar membrane-associated protein
FT                                IML1.
FT                                /FTId=PRO_0000301771.
FT   DOMAIN     1147   1222       DEP. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00066}.
SQ   SEQUENCE   1560 AA;  179600 MW;  8DBE9C7980273C85 CRC64;
     MHDARIFNSS SNKTMNQNDE AGKSKIKPLR TNQRRVIGAS KSSSHMGSHV GTTLIIGKNS
     HSTSHGVRNN SPENTIVIGR RNFSDGQIEY TKPASHSNKF KKDSILRDPN IDSNVEASKK
     LSEQIQLTVW FHEPRTSTED VIIDASVIPG LKEGDICELV PLNTFKPHKK PKRLIFIIKN
     QSLLSKSSSL HTSNNNNNAG ATTSTLSANN NNTTKTKTNF QISLISNPLQ NLMDLPPRSL
     VQLKTILDVE SIEADTIEIF IKDINLSRDL MWTFSSSLVG TCVYSEKRLT FLSNRTGVVK
     KIYKNGNELF SALICEKTKV VFRSKSAKLV FLVQLSREMW HFEETGEIMF HKLVNTLFPK
     IFKKWRDKNT HHAITIVLFT SVDLTNIPWT SLGQGERPNN RRDYFRVVVD QVSIFHWDRI
     MANLRLEFAN FKRDIMLNCQ PENNGKFTMA GQSLPSVKGN VLEAINVGIH LVNDRFKNTD
     LKHSLNHFIL VTPGTGLFDV DYSLMHETSK KMLSIDCALD IVCLSQPPLH IVPLFRYRDP
     SKDGQISHCV PHWCDISFYK DSTANSTQWI PHCKIYELQM MGVMENEIND VKIERYRVPN
     EAKSMVEAMD KYDSDVFKPV NKDSDSKVTR ELSSSPEQST INSKTGTPKE NSKPLSLIWN
     NRTSLLPNSS TARIDVSTTN SSVLGTVANS GKDVSALSSL YTLNKTSADK SVVHAPSIRA
     DSRKGVKENV SRDRKEFNEI TRTKLRPRLQ KTEEFYKSDD SVSNTSKSRD ILDSKSRNKQ
     SSTKVEEEFE TLTNLLWTEI RNPSKESHSD MLSFLRLSRW NDIFPSNIKR RLVKWRSFES
     PAALPVTTSI FPSTKQLETD YSFQIYSVFL NSENDLEIES THDLMREMIQ LRLLLGFQIC
     YSDQVKKFES SRKPGGNAES LIKYFPKGSC YGSRIYMSLD DEIHRISCDY NGNLYVQMYR
     KIEELKHSRL LGSKDYRQQS YVPLIRTRYV DEYAPAKFDF INTKPLKYNW NQFDQLIAGY
     DDAIPPEKRQ FHKMKFVVLP ANIPKNAYFI SNENLTDEEI RVEGLRKLIG LIERGKFVKS
     DDKESKRKEE ILPEISFYTG NLYEFLSDQA ETYDATGNEP SNSLMLGENM RFTKSIKLSQ
     LAQELQSPTG VRLVDRTWHF KRHLHCFLGN ELVSWFIECF EDIDNRNDAT SYGQSLMDRG
     MIKHVESRHG FLDGYYFYTF EGEYIDKNYK PERLNSGWFN RKKNSSEKGS AVTSPTYTRN
     NSDTESAKSP VFPVQDNLDL RKITSNSIGQ HMYDSETSSM AGSSTKTKQK KKFILSRSVK
     FNADPLKKSF RPEIVTVHYD RVHNPEHCYH IRLQWLNTTK KFIDDAILNW SRLCERHGLK
     LVETPWLELC TIPQVNPFHS FVDLKLVINP WTDPEFSDPN ILKDNKFYYH LYLMKKSDFL
     LDNRSTVFFS KDHIEISYSW GKPIFQYAQY IHKTGAYIVE LRDNGDLFLA PNNIHITRLN
     TSLSSVPEQD YLKSYKMDSQ KVMLKFRSAC TNEKILRGIF KEAKENWREK CSEVVLPAIN
//

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