(data stored in ACNUC6288 zone)

SWISSPROT: SRP68_DEBHA

ID   SRP68_DEBHA             Reviewed;         587 AA.
AC   Q6BMV4;
DT   24-JAN-2006, integrated into UniProtKB/Swiss-Prot.
DT   16-AUG-2004, sequence version 1.
DT   11-DEC-2019, entry version 67.
DE   RecName: Full=Signal recognition particle subunit SRP68;
DE   AltName: Full=Signal recognition particle 68 kDa protein homolog;
GN   Name=SRP68; OrderedLocusNames=DEHA2F02354g;
OS   Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / JCM 1990 / NBRC 0083 /
OS   IGC 2968) (Yeast) (Torulaspora hansenii).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Debaryomycetaceae; Debaryomyces.
OX   NCBI_TaxID=284592;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 36239 / CBS 767 / JCM 1990 / NBRC 0083 / IGC 2968;
RX   PubMed=15229592; DOI=10.1038/nature02579;
RA   Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA   de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA   Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA   Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA   Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA   Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA   Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA   Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA   Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA   Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA   Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA   Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA   Weissenbach J., Wincker P., Souciet J.-L.;
RT   "Genome evolution in yeasts.";
RL   Nature 430:35-44(2004).
CC   -!- FUNCTION: Signal-recognition-particle assembly has a crucial role in
CC       targeting secretory proteins to the rough endoplasmic reticulum
CC       membrane. SRP68 binds the 7S RNA, SRP72 binds to this complex
CC       subsequently. This ribonucleoprotein complex might interact directly
CC       with the docking protein in the ER membrane and possibly participate in
CC       the elongation arrest function (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Fungal signal recognition particle consists of a 7S RNA
CC       molecule (scR1) and at least six protein subunits: SRP72, SRP68, SRP54,
CC       SEC65, SRP21 and SRP14. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the SRP68 family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=CAG88773.2; Type=Erroneous initiation; Evidence={ECO:0000305};
DR   EMBL; CR382138; CAG88773.2; ALT_INIT; Genomic_DNA.
DR   RefSeq; XP_460466.2; XM_460466.2.
DR   STRING; 4959.XP_460466.2; -.
DR   PRIDE; Q6BMV4; -.
DR   EnsemblFungi; CAG88773; CAG88773; DEHA2F02354g.
DR   GeneID; 2903971; -.
DR   KEGG; dha:DEHA2F02354g; -.
DR   HOGENOM; HOG000246775; -.
DR   InParanoid; Q6BMV4; -.
DR   KO; K03107; -.
DR   OrthoDB; 1019762at2759; -.
DR   Proteomes; UP000000599; Chromosome F.
DR   GO; GO:0005786; C:signal recognition particle, endoplasmic reticulum targeting; IEA:UniProtKB-KW.
DR   GO; GO:0008312; F:7S RNA binding; IEA:InterPro.
DR   GO; GO:0030942; F:endoplasmic reticulum signal peptide binding; IEA:InterPro.
DR   GO; GO:0005047; F:signal recognition particle binding; IEA:InterPro.
DR   GO; GO:0006614; P:SRP-dependent cotranslational protein targeting to membrane; IEA:InterPro.
DR   CDD; cd15481; SRP68-RBD; 1.
DR   Gene3D; 1.10.3450.40; -; 1.
DR   InterPro; IPR026258; SRP68.
DR   InterPro; IPR034652; SRP68-RBD.
DR   InterPro; IPR038253; SRP68_N_sf.
DR   PANTHER; PTHR12860; PTHR12860; 1.
DR   Pfam; PF16969; SRP68; 1.
DR   PIRSF; PIRSF038995; SRP68; 1.
PE   3: Inferred from homology;
DR   PRODOM; Q6BMV4.
DR   SWISS-2DPAGE; Q6BMV4.
KW   Cytoplasm; Reference proteome; Ribonucleoprotein; RNA-binding;
KW   Signal recognition particle.
FT   CHAIN           1..587
FT                   /note="Signal recognition particle subunit SRP68"
FT                   /id="PRO_0000135231"
SQ   SEQUENCE   587 AA;  67409 MW;  A03325959EEA7706 CRC64;
     MSAYLSSSED YHKQRKRLNK RLLKLRHELD LITPDTKDYK KKEKISKISS SDYDQDEKYG
     LLLLLTAERD SLYSSEIKSL LEISNDNASS YRNLMISRIK KSLSSSKKLL EITVNEKDEY
     KRIEYYTYAA LIQGNLSVNK KQWSKALNAF SIAKCALDFL YSQEDSKMDI EEEQEESTQF
     KKTLISEITE TLVDPSLALA ISQDDTAYST TTDLKTVSRQ HCRDNKLSYL QPVIEIIARI
     DPEAVSEVSS STELIKSVQW RDHEATLYND ELAYKIMKLT NDNETNWKNF NDANQFDVLL
     SGWSELLEIH TNDMDKNKDE DDLEKVQDRA IVLTYINFNL LFTRLKRDLL IIDQLSSQGD
     NVFALKKLEF NKDIIRLYGT IITTTQEIKD LPGVYNDEDL HESLDNLEKF FVAKKSAVLA
     RSFALNNKFP EALKIFDHVD NTLSSSDNKF YKIDEFPYNV SSNVEFEKFK KELPSQVLQA
     QILAQFSVDL SKNLNQSNFV IENMNKYPVS NETLDNIANF NKNLSIAPVL SKPVLFDIGF
     NYINYGMGRS SSYNNSNSAT STTSDSTTDQ NDPNKKKSGF FGIFGRS
//

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