(data stored in ACNUC6288 zone)

SWISSPROT: IPI3_DEBHA

ID   IPI3_DEBHA              Reviewed;         515 AA.
AC   Q6BMP5;
DT   23-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT   16-DEC-2008, sequence version 2.
DT   10-APR-2019, entry version 94.
DE   RecName: Full=Pre-rRNA-processing protein IPI3;
GN   Name=IPI3; OrderedLocusNames=DEHA2F03674g;
OS   Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / JCM 1990 / NBRC
OS   0083 / IGC 2968) (Yeast) (Torulaspora hansenii).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina;
OC   Saccharomycetes; Saccharomycetales; Debaryomycetaceae; Debaryomyces.
OX   NCBI_TaxID=284592;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 36239 / CBS 767 / JCM 1990 / NBRC 0083 / IGC 2968;
RX   PubMed=15229592; DOI=10.1038/nature02579;
RA   Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S.,
RA   Lafontaine I., de Montigny J., Marck C., Neuveglise C., Talla E.,
RA   Goffard N., Frangeul L., Aigle M., Anthouard V., Babour A., Barbe V.,
RA   Barnay S., Blanchin S., Beckerich J.-M., Beyne E., Bleykasten C.,
RA   Boisrame A., Boyer J., Cattolico L., Confanioleri F., de Daruvar A.,
RA   Despons L., Fabre E., Fairhead C., Ferry-Dumazet H., Groppi A.,
RA   Hantraye F., Hennequin C., Jauniaux N., Joyet P., Kachouri R.,
RA   Kerrest A., Koszul R., Lemaire M., Lesur I., Ma L., Muller H.,
RA   Nicaud J.-M., Nikolski M., Oztas S., Ozier-Kalogeropoulos O.,
RA   Pellenz S., Potier S., Richard G.-F., Straub M.-L., Suleau A.,
RA   Swennen D., Tekaia F., Wesolowski-Louvel M., Westhof E., Wirth B.,
RA   Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M., Thierry A.,
RA   Bouchier C., Caudron B., Scarpelli C., Gaillardin C., Weissenbach J.,
RA   Wincker P., Souciet J.-L.;
RT   "Genome evolution in yeasts.";
RL   Nature 430:35-44(2004).
CC   -!- FUNCTION: Component of the RIX1 complex required for processing of
CC       ITS2 sequences from 35S pre-rRNA. {ECO:0000250|UniProtKB:P53877}.
CC   -!- SUBUNIT: Component of the RIX1 complex, composed of IPI1,
CC       RIX1/IPI2 and IPI3 in a 1:2:2 stoichiometry. The complex interacts
CC       (via RIX1) with MDN1 (via its hexameric AAA ATPase ring) and the
CC       pre-60S ribosome particles. {ECO:0000250|UniProtKB:P53877}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:P53877}.
CC   -!- SIMILARITY: Belongs to the WD repeat IPI3/WDR18 family.
CC       {ECO:0000305}.
DR   EMBL; CR382138; CAG88840.2; -; Genomic_DNA.
DR   RefSeq; XP_460526.2; XM_460526.1.
DR   STRING; 4959.XP_460526.2; -.
DR   PRIDE; Q6BMP5; -.
DR   EnsemblFungi; CAG88840; CAG88840; DEHA2F03674g.
DR   GeneID; 2903431; -.
DR   KEGG; dha:DEHA2F03674g; -.
DR   HOGENOM; HOG000093334; -.
DR   InParanoid; Q6BMP5; -.
DR   KO; K14829; -.
DR   OMA; HYQAITK; -.
DR   OrthoDB; 747023at2759; -.
DR   Proteomes; UP000000599; Chromosome F.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0006364; P:rRNA processing; IEA:UniProtKB-KW.
DR   Gene3D; 2.130.10.10; -; 1.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR001680; WD40_repeat.
DR   InterPro; IPR017986; WD40_repeat_dom.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   Pfam; PF00400; WD40; 1.
DR   SMART; SM00320; WD40; 4.
DR   SUPFAM; SSF50978; SSF50978; 1.
DR   PROSITE; PS50082; WD_REPEATS_2; 1.
DR   PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE   3: Inferred from homology;
DR   PRODOM; Q6BMP5.
DR   SWISS-2DPAGE; Q6BMP5.
KW   Complete proteome; Nucleus; Reference proteome; Repeat;
KW   Ribosome biogenesis; rRNA processing; WD repeat.
FT   CHAIN         1    515       Pre-rRNA-processing protein IPI3.
FT                                /FTId=PRO_0000308739.
FT   REPEAT      104    143       WD 1.
FT   REPEAT      146    185       WD 2.
FT   REPEAT      202    245       WD 3.
FT   REPEAT      334    375       WD 4.
SQ   SEQUENCE   515 AA;  57146 MW;  F788333BB14B7B8A CRC64;
     MDESVFYISE GDPADKHSQE SFGHSSSVHS SQQHAGFRQA DCPQNGACLS GVGTGERLFV
     ASPNKALINV YSWGKESPDQ RIPIPEQLSC LTLCKHPRIK VSEGRQSDER NLPSFRTPWL
     LAGGSKTGKI YVWELASGNL LCVKEAHYQA ITAIKFSQCG TFLVSGSSDA RCMVWRTSDL
     ISVYNKDEES SINIKPFASF TDHSLPITDL AISEAGIISD LRLYTVSRDS TLRIYDIMTK
     SLLTTFVLPS GIECVTKDPA NRACYVGLSN GLIRTVPLYQ INPNTSVLES IGGRGKIVTL
     DTDPNLLSTF VHHQQRLSTE PLHKTLNKKT TTEEKPILVT RLSITMDGSN LISGDSAGRV
     YVSDIVSRQV VKTFAPCKSS ISYIQVNACA AEKVSVSNTS SNNNDKRHRL IPQFKRVLAN
     PDPLEHQLYM EIPKQQEDEE DFESWLARKS QEELEFRNLT HINSSVTVTG AAPTTNDSTV
     KELEEKLAKV SKAYTDLRGK HEELYEEHNR LLSDS
//

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