(data stored in ACNUC6288 zone)

SWISSPROT: Q6BMD5_DEBHA

ID   Q6BMD5_DEBHA            Unreviewed;       362 AA.
AC   Q6BMD5;
DT   16-AUG-2004, integrated into UniProtKB/TrEMBL.
DT   04-NOV-2008, sequence version 2.
DT   08-MAY-2019, entry version 95.
DE   RecName: Full=Uroporphyrinogen decarboxylase {ECO:0000256|RuleBase:RU000554};
DE            EC=4.1.1.37 {ECO:0000256|RuleBase:RU000554};
GN   OrderedLocusNames=DEHA2F06402g {ECO:0000313|EMBL:CAG88968.2};
OS   Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / JCM 1990 / NBRC
OS   0083 / IGC 2968) (Yeast) (Torulaspora hansenii).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina;
OC   Saccharomycetes; Saccharomycetales; Debaryomycetaceae; Debaryomyces.
OX   NCBI_TaxID=284592 {ECO:0000313|EMBL:CAG88968.2, ECO:0000313|Proteomes:UP000000599};
RN   [1] {ECO:0000313|EMBL:CAG88968.2, ECO:0000313|Proteomes:UP000000599}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 36239 / CBS 767 / JCM 1990 / NBRC 0083 / IGC 2968
RC   {ECO:0000313|Proteomes:UP000000599};
RX   PubMed=15229592; DOI=10.1038/nature02579;
RG   Genolevures;
RA   Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S.,
RA   Lafontaine I., de Montigny J., Marck C., Neuveglise C., Talla E.,
RA   Goffard N., Frangeul L., Aigle M., Anthouard V., Babour A., Barbe V.,
RA   Barnay S., Blanchin S., Beckerich J.M., Beyne E., Bleykasten C.,
RA   Boisrame A., Boyer J., Cattolico L., Confanioleri F., de Daruvar A.,
RA   Despons L., Fabre E., Fairhead C., Ferry-Dumazet H., Groppi A.,
RA   Hantraye F., Hennequin C., Jauniaux N., Joyet P., Kachouri R.,
RA   Kerrest A., Koszul R., Lemaire M., Lesur I., Ma L., Muller H.,
RA   Nicaud J.M., Nikolski M., Oztas S., Ozier-Kalogeropoulos O.,
RA   Pellenz S., Potier S., Richard G.F., Straub M.L., Suleau A.,
RA   Swennene D., Tekaia F., Wesolowski-Louvel M., Westhof E., Wirth B.,
RA   Zeniou-Meyer M., Zivanovic I., Bolotin-Fukuhara M., Thierry A.,
RA   Bouchier C., Caudron B., Scarpelli C., Gaillardin C., Weissenbach J.,
RA   Wincker P., Souciet J.L.;
RT   "Genome evolution in yeasts.";
RL   Nature 430:35-44(2004).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=4 H(+) + uroporphyrinogen III = 4 CO2 +
CC         coproporphyrinogen III; Xref=Rhea:RHEA:19865, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:16526, ChEBI:CHEBI:57308, ChEBI:CHEBI:57309;
CC         EC=4.1.1.37; Evidence={ECO:0000256|RuleBase:RU000554};
CC   -!- PATHWAY: Porphyrin-containing compound metabolism; protoporphyrin-
CC       IX biosynthesis; coproporphyrinogen-III from 5-aminolevulinate:
CC       step 4/4. {ECO:0000256|RuleBase:RU000554}.
CC   -!- SIMILARITY: Belongs to the uroporphyrinogen decarboxylase family.
CC       {ECO:0000256|RuleBase:RU004169}.
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DR   EMBL; CR382138; CAG88968.2; -; Genomic_DNA.
DR   RefSeq; XP_460636.2; XM_460636.1.
DR   STRING; 4959.XP_460636.2; -.
DR   EnsemblFungi; CAG88968; CAG88968; DEHA2F06402g.
DR   GeneID; 2903147; -.
DR   KEGG; dha:DEHA2F06402g; -.
DR   HOGENOM; HOG000253896; -.
DR   InParanoid; Q6BMD5; -.
DR   KO; K01599; -.
DR   OMA; GSSKDFR; -.
DR   OrthoDB; 1114675at2759; -.
DR   UniPathway; UPA00251; UER00321.
DR   Proteomes; UP000000599; Chromosome F.
DR   GO; GO:0004853; F:uroporphyrinogen decarboxylase activity; IEA:UniProtKB-EC.
DR   GO; GO:0006782; P:protoporphyrinogen IX biosynthetic process; IEA:UniProtKB-UniPathway.
DR   CDD; cd00717; URO-D; 1.
DR   Gene3D; 3.20.20.210; -; 1.
DR   HAMAP; MF_00218; URO_D; 1.
DR   InterPro; IPR038071; UROD/MetE-like_sf.
DR   InterPro; IPR006361; Uroporphyrinogen_deCO2ase_HemE.
DR   InterPro; IPR000257; Uroporphyrinogen_deCOase.
DR   Pfam; PF01208; URO-D; 1.
DR   SUPFAM; SSF51726; SSF51726; 1.
DR   TIGRFAMs; TIGR01464; hemE; 1.
DR   PROSITE; PS00906; UROD_1; 1.
DR   PROSITE; PS00907; UROD_2; 1.
PE   3: Inferred from homology;
DR   PRODOM; Q6BMD5.
DR   SWISS-2DPAGE; Q6BMD5.
KW   Complete proteome {ECO:0000313|Proteomes:UP000000599};
KW   Decarboxylase {ECO:0000256|RuleBase:RU000554};
KW   Lyase {ECO:0000256|RuleBase:RU000554};
KW   Porphyrin biosynthesis {ECO:0000256|RuleBase:RU000554};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000599}.
FT   DOMAIN       25     34       Uroporphyrinogen_deCOase.
FT                                {ECO:0000259|PROSITE:PS00906}.
FT   DOMAIN      147    163       Uroporphyrinogen_deCOase.
FT                                {ECO:0000259|PROSITE:PS00907}.
SQ   SEQUENCE   362 AA;  41124 MW;  381FCE2FEF3E267D CRC64;
     MPEFAPLKND LILRAARGEK VERPPMWIMR QAGRYLPEYH EVKGKLDFFE TCRNAEIAAE
     ITIQPIEHFN GLIDAAIIFS DILVIPQVMG FEIEMVEGKG PVFVDPLRSP KDLSRVNYKP
     DILKGLDWAF KAITLTRTKL NGRVPLLGFC GAPWTLLVYM TEGQGSKMFR YAKEWIYEHT
     EESHKLLQAT TDACIEFLAQ QVVAGAQMLQ VFESWASELG PNEFNEFSLP YLRQISEKLP
     KRLQELGITE KIPLTVFAKG AWYALDSLCD SGYDTVSLDW LYKPEDAVKV VNGRRITLQG
     NLDPGTIYGS DEVISKKVEQ MIKGFGGGKQ NYIINFGHGT HPFMKPEKVE HFLKECHRFG
     SQ
//

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