(data stored in ACNUC6288 zone)

SWISSPROT: Q6BM68_DEBHA

ID   Q6BM68_DEBHA            Unreviewed;       251 AA.
AC   Q6BM68;
DT   16-AUG-2004, integrated into UniProtKB/TrEMBL.
DT   04-NOV-2008, sequence version 2.
DT   08-MAY-2019, entry version 82.
DE   RecName: Full=Protein-lysine N-methyltransferase EFM4 {ECO:0000256|HAMAP-Rule:MF_03188};
DE            EC=2.1.1.- {ECO:0000256|HAMAP-Rule:MF_03188};
DE   AltName: Full=Elongation factor methyltransferase 4 {ECO:0000256|HAMAP-Rule:MF_03188};
GN   Name=EFM4 {ECO:0000256|HAMAP-Rule:MF_03188};
GN   OrderedLocusNames=DEHA2F07898g {ECO:0000313|EMBL:CAG89043.2};
OS   Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / JCM 1990 / NBRC
OS   0083 / IGC 2968) (Yeast) (Torulaspora hansenii).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina;
OC   Saccharomycetes; Saccharomycetales; Debaryomycetaceae; Debaryomyces.
OX   NCBI_TaxID=284592 {ECO:0000313|EMBL:CAG89043.2, ECO:0000313|Proteomes:UP000000599};
RN   [1] {ECO:0000313|EMBL:CAG89043.2, ECO:0000313|Proteomes:UP000000599}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 36239 / CBS 767 / JCM 1990 / NBRC 0083 / IGC 2968
RC   {ECO:0000313|Proteomes:UP000000599};
RX   PubMed=15229592; DOI=10.1038/nature02579;
RG   Genolevures;
RA   Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S.,
RA   Lafontaine I., de Montigny J., Marck C., Neuveglise C., Talla E.,
RA   Goffard N., Frangeul L., Aigle M., Anthouard V., Babour A., Barbe V.,
RA   Barnay S., Blanchin S., Beckerich J.M., Beyne E., Bleykasten C.,
RA   Boisrame A., Boyer J., Cattolico L., Confanioleri F., de Daruvar A.,
RA   Despons L., Fabre E., Fairhead C., Ferry-Dumazet H., Groppi A.,
RA   Hantraye F., Hennequin C., Jauniaux N., Joyet P., Kachouri R.,
RA   Kerrest A., Koszul R., Lemaire M., Lesur I., Ma L., Muller H.,
RA   Nicaud J.M., Nikolski M., Oztas S., Ozier-Kalogeropoulos O.,
RA   Pellenz S., Potier S., Richard G.F., Straub M.L., Suleau A.,
RA   Swennene D., Tekaia F., Wesolowski-Louvel M., Westhof E., Wirth B.,
RA   Zeniou-Meyer M., Zivanovic I., Bolotin-Fukuhara M., Thierry A.,
RA   Bouchier C., Caudron B., Scarpelli C., Gaillardin C., Weissenbach J.,
RA   Wincker P., Souciet J.L.;
RT   "Genome evolution in yeasts.";
RL   Nature 430:35-44(2004).
CC   -!- FUNCTION: S-adenosyl-L-methionine-dependent protein-lysine N-
CC       methyltransferase that mono- and dimethylates elongation factor 1-
CC       alpha at 'Lys-316'. May play a role in intracellular transport.
CC       {ECO:0000256|HAMAP-Rule:MF_03188}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_03188}.
CC   -!- SIMILARITY: Belongs to the class I-like SAM-binding
CC       methyltransferase superfamily. EFM4 family. {ECO:0000256|HAMAP-
CC       Rule:MF_03188}.
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DR   EMBL; CR382138; CAG89043.2; -; Genomic_DNA.
DR   RefSeq; XP_460703.2; XM_460703.1.
DR   STRING; 4959.XP_460703.2; -.
DR   EnsemblFungi; CAG89043; CAG89043; DEHA2F07898g.
DR   GeneID; 2903506; -.
DR   KEGG; dha:DEHA2F07898g; -.
DR   HOGENOM; HOG000184298; -.
DR   InParanoid; Q6BM68; -.
DR   KO; K22856; -.
DR   OMA; LGTKQYW; -.
DR   OrthoDB; 1422013at2759; -.
DR   Proteomes; UP000000599; Chromosome F.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0016279; F:protein-lysine N-methyltransferase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0016192; P:vesicle-mediated transport; IEA:UniProtKB-UniRule.
DR   HAMAP; MF_03188; Methyltr_EFM4; 1.
DR   InterPro; IPR026635; Efm4/METTL10.
DR   InterPro; IPR025714; Methyltranfer_dom.
DR   InterPro; IPR029063; SAM-dependent_MTases.
DR   Pfam; PF13847; Methyltransf_31; 1.
DR   SUPFAM; SSF53335; SSF53335; 1.
PE   3: Inferred from homology;
DR   PRODOM; Q6BM68.
DR   SWISS-2DPAGE; Q6BM68.
KW   Complete proteome {ECO:0000313|Proteomes:UP000000599};
KW   Cytoplasm {ECO:0000256|HAMAP-Rule:MF_03188};
KW   Methyltransferase {ECO:0000256|HAMAP-Rule:MF_03188};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000599};
KW   S-adenosyl-L-methionine {ECO:0000256|HAMAP-Rule:MF_03188};
KW   Transferase {ECO:0000256|HAMAP-Rule:MF_03188};
KW   Transport {ECO:0000256|HAMAP-Rule:MF_03188}.
FT   DOMAIN       68    237       Methyltranfer_dom. {ECO:0000259|Pfam:
FT                                PF13847}.
SQ   SEQUENCE   251 AA;  28531 MW;  19797371686D3F56 CRC64;
     MSNEIRLNSS KLGTKEYWNS FYKKEIANFQ DNEEDTGECW FDDSDAESKM IQFLIDKING
     EELPFGKQEN IKIVDLGTGN GHLLFQLHED ILEECDYQDQ IKFDFMGIDY SPDSVEFATK
     IAKQKYPQAA FQFEQVDLLT KENKFLSANT SQFDILLDKG TLDAIALNQD PISELGDKIG
     MDVYASQVSQ LMHQNSVLLI TSCNFTESEL IKIITQDKTN SLSVWNKIDY PSFQFGGVKG
     STICSIAFIK N
//

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