(data stored in ACNUC6288 zone)

SWISSPROT: PEX5_DEBHA

ID   PEX5_DEBHA              Reviewed;         603 AA.
AC   Q6BM14;
DT   24-JAN-2006, integrated into UniProtKB/Swiss-Prot.
DT   16-DEC-2008, sequence version 2.
DT   08-MAY-2019, entry version 93.
DE   RecName: Full=Peroxisomal targeting signal receptor;
DE            Short=PTS1 receptor;
DE            Short=PTS1R;
DE   AltName: Full=Peroxin-5;
GN   Name=PEX5; OrderedLocusNames=DEHA2F09108g;
OS   Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / JCM 1990 / NBRC
OS   0083 / IGC 2968) (Yeast) (Torulaspora hansenii).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina;
OC   Saccharomycetes; Saccharomycetales; Debaryomycetaceae; Debaryomyces.
OX   NCBI_TaxID=284592;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 36239 / CBS 767 / JCM 1990 / NBRC 0083 / IGC 2968;
RX   PubMed=15229592; DOI=10.1038/nature02579;
RA   Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S.,
RA   Lafontaine I., de Montigny J., Marck C., Neuveglise C., Talla E.,
RA   Goffard N., Frangeul L., Aigle M., Anthouard V., Babour A., Barbe V.,
RA   Barnay S., Blanchin S., Beckerich J.-M., Beyne E., Bleykasten C.,
RA   Boisrame A., Boyer J., Cattolico L., Confanioleri F., de Daruvar A.,
RA   Despons L., Fabre E., Fairhead C., Ferry-Dumazet H., Groppi A.,
RA   Hantraye F., Hennequin C., Jauniaux N., Joyet P., Kachouri R.,
RA   Kerrest A., Koszul R., Lemaire M., Lesur I., Ma L., Muller H.,
RA   Nicaud J.-M., Nikolski M., Oztas S., Ozier-Kalogeropoulos O.,
RA   Pellenz S., Potier S., Richard G.-F., Straub M.-L., Suleau A.,
RA   Swennen D., Tekaia F., Wesolowski-Louvel M., Westhof E., Wirth B.,
RA   Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M., Thierry A.,
RA   Bouchier C., Caudron B., Scarpelli C., Gaillardin C., Weissenbach J.,
RA   Wincker P., Souciet J.-L.;
RT   "Genome evolution in yeasts.";
RL   Nature 430:35-44(2004).
CC   -!- FUNCTION: Binds to the C-terminal PTS1-type tripeptide peroxisomal
CC       targeting signal (SKL-type) and plays an essential role in
CC       peroxisomal protein import. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Peroxisome membrane
CC       {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Note=Its
CC       distribution appears to be dynamic. It is probably a cycling
CC       receptor found mainly in the cytoplasm and as well associated to
CC       the peroxisomal membrane (By similarity). {ECO:0000250}.
CC   -!- PTM: Ubiquitination at Cys-10 is UBC4-independent but requires the
CC       presence of PEX4. Ubiquitination at Lys-22 is UBC4-dependent (By
CC       similarity). {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the peroxisomal targeting signal receptor
CC       family. {ECO:0000305}.
DR   EMBL; CR382138; CAG89098.2; -; Genomic_DNA.
DR   RefSeq; XP_460757.2; XM_460757.1.
DR   SMR; Q6BM14; -.
DR   STRING; 4959.XP_460757.2; -.
DR   EnsemblFungi; CAG89098; CAG89098; DEHA2F09108g.
DR   GeneID; 2903774; -.
DR   KEGG; dha:DEHA2F09108g; -.
DR   HOGENOM; HOG000158146; -.
DR   InParanoid; Q6BM14; -.
DR   KO; K13342; -.
DR   OMA; LSQFTKH; -.
DR   OrthoDB; 588648at2759; -.
DR   Proteomes; UP000000599; Chromosome F.
DR   GO; GO:0005778; C:peroxisomal membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR   Gene3D; 1.25.40.10; -; 1.
DR   InterPro; IPR024111; PTS1R_family.
DR   InterPro; IPR013026; TPR-contain_dom.
DR   InterPro; IPR011990; TPR-like_helical_dom_sf.
DR   InterPro; IPR001440; TPR_1.
DR   InterPro; IPR019734; TPR_repeat.
DR   PANTHER; PTHR10130; PTHR10130; 1.
DR   Pfam; PF00515; TPR_1; 1.
DR   SMART; SM00028; TPR; 4.
DR   SUPFAM; SSF48452; SSF48452; 1.
DR   PROSITE; PS50005; TPR; 4.
DR   PROSITE; PS50293; TPR_REGION; 1.
PE   3: Inferred from homology;
DR   PRODOM; Q6BM14.
DR   SWISS-2DPAGE; Q6BM14.
KW   Coiled coil; Complete proteome; Cytoplasm; Isopeptide bond; Membrane;
KW   Peroxisome; Protein transport; Reference proteome; Repeat;
KW   Thioester bond; TPR repeat; Transport; Ubl conjugation.
FT   CHAIN         1    603       Peroxisomal targeting signal receptor.
FT                                /FTId=PRO_0000106310.
FT   REPEAT      304    338       TPR 1.
FT   REPEAT      339    372       TPR 2.
FT   REPEAT      449    482       TPR 3.
FT   REPEAT      484    516       TPR 4.
FT   REPEAT      518    550       TPR 5.
FT   COILED      192    259       {ECO:0000255}.
FT   COMPBIAS    151    179       Met-rich.
FT   CROSSLNK     10     10       Glycyl cysteine thioester (Cys-Gly)
FT                                (interchain with G-Cter in ubiquitin).
FT                                {ECO:0000250}.
FT   CROSSLNK     22     22       Glycyl lysine isopeptide (Lys-Gly)
FT                                (interchain with G-Cter in ubiquitin).
FT                                {ECO:0000250}.
SQ   SEQUENCE   603 AA;  68734 MW;  F30230B4AAF68147 CRC64;
     MSFVGGGADC SANSNAIAQF NKHTQQDRSL QRQAANQQGI VQNGQGFKKD SMMNERERQN
     MDQFMNNGPS QSNFQFQPMR HELNMIQQNH KQPNVQNNWT NEFQTNSPSP VQRNTPLAKT
     GSPANAQWAT EFQQPMDQTF NQSNQQQFNN MPNMRMGGYR PMMGMSMMGG GMHQQQNQMQ
     HQEQNQDHQV DWDNQFKEIE QLTNETKDAE AEQVKGEEEP EIVIDDKYQA TFQEVWDSLN
     SEEVENDFIN QQYEEFKNTQ RDSMPADMAQ WEKDFAKYAS TRAHFGDYQF EDNQHNQFLD
     LPKESDPYEI GLQLMENGAK LSEAALAFEA AIQRNEGHIN AWLKLGEVQT QNEKEIAGIS
     ALEKCLELHP ENSEALMTLA ISYINEGYDN AAFATLERWI STKYPQVADQ ARQQNPAIDD
     EDRFSLNKRV TELFLNAAQL SPNSANMDPD VQMGLGVLFY ANEDFDKTID CFKAALSIKP
     DDAVLWNRLG ASLANSNRSE EAVDAYFKAL ELKPTFVRAR YNLGVSCINI GCYKEAAEHL
     LSGLSMHQVE GVQTDASSTL NHNQSTSLTE TLKRAFIALD RRDLLEKVKP DMDINQFRGE
     FSF
//

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