(data stored in ACNUC6288 zone)

SWISSPROT: NACB_DEBHA

ID   NACB_DEBHA              Reviewed;         154 AA.
AC   Q6BLV1;
DT   23-JAN-2007, integrated into UniProtKB/Swiss-Prot.
DT   16-AUG-2004, sequence version 1.
DT   08-MAY-2019, entry version 74.
DE   RecName: Full=Nascent polypeptide-associated complex subunit beta;
DE            Short=NAC-beta;
DE   AltName: Full=Beta-NAC;
GN   Name=EGD1; OrderedLocusNames=DEHA2F10494g;
OS   Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / JCM 1990 / NBRC
OS   0083 / IGC 2968) (Yeast) (Torulaspora hansenii).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina;
OC   Saccharomycetes; Saccharomycetales; Debaryomycetaceae; Debaryomyces.
OX   NCBI_TaxID=284592;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 36239 / CBS 767 / JCM 1990 / NBRC 0083 / IGC 2968;
RX   PubMed=15229592; DOI=10.1038/nature02579;
RA   Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S.,
RA   Lafontaine I., de Montigny J., Marck C., Neuveglise C., Talla E.,
RA   Goffard N., Frangeul L., Aigle M., Anthouard V., Babour A., Barbe V.,
RA   Barnay S., Blanchin S., Beckerich J.-M., Beyne E., Bleykasten C.,
RA   Boisrame A., Boyer J., Cattolico L., Confanioleri F., de Daruvar A.,
RA   Despons L., Fabre E., Fairhead C., Ferry-Dumazet H., Groppi A.,
RA   Hantraye F., Hennequin C., Jauniaux N., Joyet P., Kachouri R.,
RA   Kerrest A., Koszul R., Lemaire M., Lesur I., Ma L., Muller H.,
RA   Nicaud J.-M., Nikolski M., Oztas S., Ozier-Kalogeropoulos O.,
RA   Pellenz S., Potier S., Richard G.-F., Straub M.-L., Suleau A.,
RA   Swennen D., Tekaia F., Wesolowski-Louvel M., Westhof E., Wirth B.,
RA   Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M., Thierry A.,
RA   Bouchier C., Caudron B., Scarpelli C., Gaillardin C., Weissenbach J.,
RA   Wincker P., Souciet J.-L.;
RT   "Genome evolution in yeasts.";
RL   Nature 430:35-44(2004).
CC   -!- FUNCTION: Component of the nascent polypeptide-associated complex
CC       (NAC), a dynamic component of the ribosomal exit tunnel,
CC       protecting the emerging polypeptides from interaction with other
CC       cytoplasmic proteins to ensure appropriate nascent protein
CC       targeting. The NAC complex also promotes mitochondrial protein
CC       import by enhancing productive ribosome interactions with the
CC       outer mitochondrial membrane and blocks the inappropriate
CC       interaction of ribosomes translating non-secretory nascent
CC       polypeptides with translocation sites in the membrane of the
CC       endoplasmic reticulum. EGD1 may act as a transcription factor that
CC       exert a negative effect on the expression of several genes that
CC       are transcribed by RNA polymerase II. {ECO:0000250}.
CC   -!- SUBUNIT: Part of the nascent polypeptide-associated complex (NAC),
CC       consisting of EGD2 and EGD1. NAC associates with ribosomes via
CC       EGD1 (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus
CC       {ECO:0000250}. Note=Predominantly cytoplasmic, may also
CC       transiently localize to the nucleus. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the NAC-beta family. {ECO:0000305}.
DR   EMBL; CR382138; CAG89163.1; -; Genomic_DNA.
DR   RefSeq; XP_460820.1; XM_460820.1.
DR   SMR; Q6BLV1; -.
DR   STRING; 4959.XP_460820.1; -.
DR   EnsemblFungi; CAG89163; CAG89163; DEHA2F10494g.
DR   GeneID; 2904334; -.
DR   KEGG; dha:DEHA2F10494g; -.
DR   HOGENOM; HOG000261245; -.
DR   InParanoid; Q6BLV1; -.
DR   KO; K01527; -.
DR   OMA; FTAPKVH; -.
DR   OrthoDB; 1435264at2759; -.
DR   Proteomes; UP000000599; Chromosome F.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR   Gene3D; 2.20.70.30; -; 1.
DR   InterPro; IPR039370; BTF3.
DR   InterPro; IPR038187; NAC_A/B_dom_sf.
DR   InterPro; IPR002715; Nas_poly-pep-assoc_cplx_dom.
DR   PANTHER; PTHR10351; PTHR10351; 1.
DR   Pfam; PF01849; NAC; 1.
DR   SMART; SM01407; NAC; 1.
DR   PROSITE; PS51151; NAC_AB; 1.
PE   3: Inferred from homology;
DR   PRODOM; Q6BLV1.
DR   SWISS-2DPAGE; Q6BLV1.
KW   Complete proteome; Cytoplasm; Nucleus; Protein transport;
KW   Reference proteome; Repressor; Transcription;
KW   Transcription regulation; Transport.
FT   CHAIN         1    154       Nascent polypeptide-associated complex
FT                                subunit beta.
FT                                /FTId=PRO_0000273509.
FT   DOMAIN       34     99       NAC-A/B. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00507}.
SQ   SEQUENCE   154 AA;  16796 MW;  9D88E531A5614DDF CRC64;
     MPVDPEKLAK LQKASVAKKV GGSRVKAKKN VKTEQDDTKL IEALGKLKAQ KIEGIEEANF
     FKEDGKVLHF NRVGVQGAAQ HNTFALTGYP QEKDVTQLIP QILPQLGAEN LEILRKLAEQ
     IQAGKNPELN AGGAEGAEED IPDLIEGQKF DDVE
//

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