(data stored in SCRATCH zone)

SWISSPROT: DCD_CHLAB

ID   DCD_CHLAB               Reviewed;         190 AA.
AC   Q5L687;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   21-JUN-2005, sequence version 1.
DT   11-DEC-2019, entry version 78.
DE   RecName: Full=dCTP deaminase {ECO:0000255|HAMAP-Rule:MF_00146};
DE            EC=3.5.4.13 {ECO:0000255|HAMAP-Rule:MF_00146};
DE   AltName: Full=Deoxycytidine triphosphate deaminase {ECO:0000255|HAMAP-Rule:MF_00146};
GN   Name=dcd {ECO:0000255|HAMAP-Rule:MF_00146}; OrderedLocusNames=CAB391;
OS   Chlamydia abortus (strain DSM 27085 / S26/3) (Chlamydophila abortus).
OC   Bacteria; Chlamydiae; Chlamydiales; Chlamydiaceae;
OC   Chlamydia/Chlamydophila group; Chlamydia.
OX   NCBI_TaxID=218497;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 27085 / S26/3;
RX   PubMed=15837807; DOI=10.1101/gr.3684805;
RA   Thomson N.R., Yeats C., Bell K., Holden M.T.G., Bentley S.D.,
RA   Livingstone M., Cerdeno-Tarraga A.-M., Harris B., Doggett J., Ormond D.,
RA   Mungall K., Clarke K., Feltwell T., Hance Z., Sanders M., Quail M.A.,
RA   Price C., Barrell B.G., Parkhill J., Longbottom D.;
RT   "The Chlamydophila abortus genome sequence reveals an array of variable
RT   proteins that contribute to interspecies variation.";
RL   Genome Res. 15:629-640(2005).
CC   -!- FUNCTION: Catalyzes the deamination of dCTP to dUTP.
CC       {ECO:0000255|HAMAP-Rule:MF_00146}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=dCTP + H(+) + H2O = dUTP + NH4(+); Xref=Rhea:RHEA:22680,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:28938,
CC         ChEBI:CHEBI:61481, ChEBI:CHEBI:61555; EC=3.5.4.13;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_00146};
CC   -!- PATHWAY: Pyrimidine metabolism; dUMP biosynthesis; dUMP from dCTP (dUTP
CC       route): step 1/2. {ECO:0000255|HAMAP-Rule:MF_00146}.
CC   -!- SUBUNIT: Homotrimer. {ECO:0000255|HAMAP-Rule:MF_00146}.
CC   -!- SIMILARITY: Belongs to the dCTP deaminase family. {ECO:0000255|HAMAP-
CC       Rule:MF_00146}.
DR   EMBL; CR848038; CAH63844.1; -; Genomic_DNA.
DR   RefSeq; WP_011097035.1; NC_004552.2.
DR   SMR; Q5L687; -.
DR   STRING; 218497.CAB391; -.
DR   EnsemblBacteria; CAH63844; CAH63844; CAB391.
DR   KEGG; cab:CAB391; -.
DR   eggNOG; ENOG4105DHP; Bacteria.
DR   eggNOG; COG0717; LUCA.
DR   HOGENOM; HOG000228600; -.
DR   KO; K01494; -.
DR   OMA; FENHRYP; -.
DR   OrthoDB; 1598407at2; -.
DR   BioCyc; CABO218497:G1GI1-420-MONOMER; -.
DR   UniPathway; UPA00610; UER00665.
DR   Proteomes; UP000001012; Chromosome.
DR   GO; GO:0008829; F:dCTP deaminase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0000166; F:nucleotide binding; IEA:UniProtKB-KW.
DR   GO; GO:0006226; P:dUMP biosynthetic process; IEA:UniProtKB-UniPathway.
DR   GO; GO:0006229; P:dUTP biosynthetic process; IEA:UniProtKB-UniRule.
DR   CDD; cd07557; trimeric_dUTPase; 1.
DR   Gene3D; 2.70.40.10; -; 1.
DR   HAMAP; MF_00146; dCTP_deaminase; 1.
DR   InterPro; IPR011962; dCTP_deaminase.
DR   InterPro; IPR029054; dUTPase-like.
DR   InterPro; IPR036157; dUTPase-like_sf.
DR   InterPro; IPR033704; dUTPase_trimeric.
DR   Pfam; PF00692; dUTPase; 1.
DR   SUPFAM; SSF51283; SSF51283; 1.
DR   TIGRFAMs; TIGR02274; dCTP_deam; 1.
PE   3: Inferred from homology;
DR   PRODOM; Q5L687.
DR   SWISS-2DPAGE; Q5L687.
KW   Hydrolase; Nucleotide metabolism; Nucleotide-binding.
FT   CHAIN           1..190
FT                   /note="dCTP deaminase"
FT                   /id="PRO_1000009703"
FT   NP_BIND         113..118
FT                   /note="dCTP binding"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00146"
FT   ACT_SITE        139
FT                   /note="Proton donor/acceptor"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00146"
FT   BINDING         158
FT                   /note="dCTP"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00146"
FT   BINDING         172
FT                   /note="dCTP"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00146"
FT   BINDING         181
FT                   /note="dCTP"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00146"
FT   BINDING         182
FT                   /note="dCTP"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00146"
SQ   SEQUENCE   190 AA;  21572 MW;  28588D39C9750925 CRC64;
     MSIKEDKWIR KMALAHGMIE PFADGQVNLN PETGEKLISY GLSSYGYDLR LSREFKVFTN
     VYNSLVDPKR FTEDTFISIT DDVCIIPPNS FALAHSVEYF RIPRNVLTMC IGKSTYARCG
     LIVNVTPFEP EWEGYVTIEI SNTTPLPAKI YANEGIAQVL FFEADEICEV SYAERKGKYQ
     KQQGITVPFV
//

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