(data stored in ACNUC7421 zone)

SWISSPROT: TSAC_PSEHT

ID   TSAC_PSEHT              Reviewed;         187 AA.
AC   Q3IDH7;
DT   04-NOV-2008, integrated into UniProtKB/Swiss-Prot.
DT   08-NOV-2005, sequence version 1.
DT   07-JUN-2017, entry version 73.
DE   RecName: Full=Threonylcarbamoyl-AMP synthase {ECO:0000255|HAMAP-Rule:MF_01852};
DE            Short=TC-AMP synthase {ECO:0000255|HAMAP-Rule:MF_01852};
DE            EC=2.7.7.87 {ECO:0000255|HAMAP-Rule:MF_01852};
DE   AltName: Full=L-threonylcarbamoyladenylate synthase {ECO:0000255|HAMAP-Rule:MF_01852};
DE   AltName: Full=t(6)A37 threonylcarbamoyladenosine biosynthesis protein TsaC {ECO:0000255|HAMAP-Rule:MF_01852};
DE   AltName: Full=tRNA threonylcarbamoyladenosine biosynthesis protein TsaC {ECO:0000255|HAMAP-Rule:MF_01852};
GN   Name=tsaC {ECO:0000255|HAMAP-Rule:MF_01852}; Synonyms=rimN;
GN   OrderedLocusNames=PSHAa0028;
OS   Pseudoalteromonas haloplanktis (strain TAC 125).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Alteromonadales;
OC   Pseudoalteromonadaceae; Pseudoalteromonas.
OX   NCBI_TaxID=326442;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=TAC 125;
RX   PubMed=16169927; DOI=10.1101/gr.4126905;
RA   Medigue C., Krin E., Pascal G., Barbe V., Bernsel A., Bertin P.N.,
RA   Cheung F., Cruveiller S., D'Amico S., Duilio A., Fang G., Feller G.,
RA   Ho C., Mangenot S., Marino G., Nilsson J., Parrilli E., Rocha E.P.C.,
RA   Rouy Z., Sekowska A., Tutino M.L., Vallenet D., von Heijne G.,
RA   Danchin A.;
RT   "Coping with cold: the genome of the versatile marine Antarctica
RT   bacterium Pseudoalteromonas haloplanktis TAC125.";
RL   Genome Res. 15:1325-1335(2005).
CC   -!- FUNCTION: Required for the formation of a threonylcarbamoyl group
CC       on adenosine at position 37 (t(6)A37) in tRNAs that read codons
CC       beginning with adenine. Catalyzes the conversion of L-threonine,
CC       HCO(3)(-)/CO(2) and ATP to give threonylcarbamoyl-AMP (TC-AMP) as
CC       the acyladenylate intermediate, with the release of diphosphate.
CC       {ECO:0000255|HAMAP-Rule:MF_01852}.
CC   -!- CATALYTIC ACTIVITY: L-threonine + ATP + HCO(3)(-) = L-
CC       threonylcarbamoyladenylate + diphosphate + H(2)O.
CC       {ECO:0000255|HAMAP-Rule:MF_01852}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_01852}.
CC   -!- SIMILARITY: Belongs to the SUA5 family. TsaC subfamily.
CC       {ECO:0000255|HAMAP-Rule:MF_01852}.
DR   EMBL; CR954246; CAI85142.1; -; Genomic_DNA.
DR   RefSeq; WP_011326760.1; NC_007481.1.
DR   ProteinModelPortal; Q3IDH7; -.
DR   SMR; Q3IDH7; -.
DR   STRING; 326442.PSHAa0028; -.
DR   EnsemblBacteria; CAI85142; CAI85142; PSHAa0028.
DR   KEGG; pha:PSHAa0028; -.
DR   PATRIC; fig|326442.8.peg.30; -.
DR   eggNOG; ENOG4105EK0; Bacteria.
DR   eggNOG; COG0009; LUCA.
DR   HOGENOM; HOG000076163; -.
DR   KO; K07566; -.
DR   OMA; FGLGCNP; -.
DR   OrthoDB; POG091H00HZ; -.
DR   Proteomes; UP000006843; Chromosome I.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0003725; F:double-stranded RNA binding; IEA:InterPro.
DR   GO; GO:0061710; F:L-threonylcarbamoyladenylate synthase; IEA:UniProtKB-EC.
DR   GO; GO:0002949; P:tRNA threonylcarbamoyladenosine modification; IEA:InterPro.
DR   Gene3D; 3.90.870.10; -; 1.
DR   HAMAP; MF_01852; TsaC; 1.
DR   InterPro; IPR017945; DHBP_synth_RibB-like_a/b_dom.
DR   InterPro; IPR023535; TC-AMP_synthase.
DR   InterPro; IPR006070; YrdC-like_dom.
DR   Pfam; PF01300; Sua5_yciO_yrdC; 1.
DR   SUPFAM; SSF55821; SSF55821; 1.
DR   TIGRFAMs; TIGR00057; TIGR00057; 1.
DR   PROSITE; PS51163; YRDC; 1.
PE   3: Inferred from homology;
DR   PRODOM; Q3IDH7.
DR   SWISS-2DPAGE; Q3IDH7.
KW   ATP-binding; Complete proteome; Cytoplasm; Nucleotide-binding;
KW   Nucleotidyltransferase; Reference proteome; Transferase;
KW   tRNA processing.
FT   CHAIN         1    187       Threonylcarbamoyl-AMP synthase.
FT                                /FTId=PRO_0000352947.
FT   DOMAIN        4    187       YrdC-like. {ECO:0000255|HAMAP-
FT                                Rule:MF_01852}.
SQ   SEQUENCE   187 AA;  20450 MW;  6E618A67468BA004 CRC64;
     MSDQSTIAAA ITCLAQGEVI LYPTEAVYGL GCDPDNQQAV ERLLAIKQRP VEKGLILIAD
     NYGQLLKYVD DAKIPMDKRA DIFSSWPNAI TWVMPAAKNT PKWLTGQYDT IAVRVTNHPT
     VKRLCQEFGK PLVSTSANLS GQNTVLSIAE AKSQFTEQIG YYVDEPLGGN TQPSTIKDAM
     NGKVFRG
//

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