(data stored in ACNUC7421 zone)

SWISSPROT: Q3IFL7_PSEHT

ID   Q3IFL7_PSEHT            Unreviewed;       914 AA.
AC   Q3IFL7;
DT   08-NOV-2005, integrated into UniProtKB/TrEMBL.
DT   08-NOV-2005, sequence version 1.
DT   07-JUN-2017, entry version 89.
DE   RecName: Full=Aconitate hydratase {ECO:0000256|RuleBase:RU361275};
DE            Short=Aconitase {ECO:0000256|RuleBase:RU361275};
DE            EC=4.2.1.3 {ECO:0000256|RuleBase:RU361275};
GN   Name=acnA {ECO:0000313|EMBL:CAI85263.1};
GN   OrderedLocusNames=PSHAa0159 {ECO:0000313|EMBL:CAI85263.1};
OS   Pseudoalteromonas haloplanktis (strain TAC 125).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Alteromonadales;
OC   Pseudoalteromonadaceae; Pseudoalteromonas.
OX   NCBI_TaxID=326442 {ECO:0000313|EMBL:CAI85263.1, ECO:0000313|Proteomes:UP000006843};
RN   [1] {ECO:0000313|EMBL:CAI85263.1, ECO:0000313|Proteomes:UP000006843}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=TAC 125 {ECO:0000313|Proteomes:UP000006843};
RX   PubMed=16169927; DOI=10.1101/gr.4126905;
RA   Medigue C., Krin E., Pascal G., Barbe V., Bernsel A., Bertin P.,
RA   Cheung F., Cruveiller S., Damico S., Duilio A., Fang G., Feller G.,
RA   Mangenot S., Marino G., Nilsson J., Parilli E., Rocha E., Rouy Z.,
RA   Sekowska A., Tutino M.L., Vallenet D., von Heijne G., Danchin A.;
RT   "Coping with cold: the genome of the versatile marine Antarctica
RT   bacterium Pseudoalteromonas haloplanktis TAC125.";
RL   Genome Res. 15:1325-1335(2005).
CC   -!- FUNCTION: Catalyzes the isomerization of citrate to isocitrate via
CC       cis-aconitate. {ECO:0000256|RuleBase:RU361275}.
CC   -!- CATALYTIC ACTIVITY: Citrate = isocitrate.
CC       {ECO:0000256|RuleBase:RU361275}.
CC   -!- COFACTOR:
CC       Note=Binds 1 [4Fe-4S] cluster per subunit.
CC       {ECO:0000256|RuleBase:RU361275};
CC   -!- SIMILARITY: Belongs to the aconitase/IPM isomerase family.
CC       {ECO:0000256|RuleBase:RU361275}.
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DR   EMBL; CR954246; CAI85263.1; -; Genomic_DNA.
DR   RefSeq; WP_011326878.1; NC_007481.1.
DR   ProteinModelPortal; Q3IFL7; -.
DR   STRING; 326442.PSHAa0159; -.
DR   EnsemblBacteria; CAI85263; CAI85263; PSHAa0159.
DR   KEGG; pha:PSHAa0159; -.
DR   PATRIC; fig|326442.8.peg.153; -.
DR   eggNOG; ENOG4107QM5; Bacteria.
DR   eggNOG; COG1048; LUCA.
DR   HOGENOM; HOG000025704; -.
DR   KO; K01681; -.
DR   OMA; MRIIPPG; -.
DR   OrthoDB; POG091H08NL; -.
DR   Proteomes; UP000006843; Chromosome I.
DR   GO; GO:0051539; F:4 iron, 4 sulfur cluster binding; IEA:UniProtKB-KW.
DR   GO; GO:0003994; F:aconitate hydratase activity; IEA:UniProtKB-EC.
DR   GO; GO:0008152; P:metabolic process; IEA:InterPro.
DR   Gene3D; 3.20.19.10; -; 1.
DR   Gene3D; 3.30.499.10; -; 2.
DR   Gene3D; 3.40.1060.10; -; 1.
DR   InterPro; IPR015931; Acnase/IPM_dHydase_lsu_aba_1/3.
DR   InterPro; IPR001030; Acoase/IPM_deHydtase_lsu_aba.
DR   InterPro; IPR015928; Aconitase/3IPM_dehydase_swvl.
DR   InterPro; IPR015932; Aconitase/IPMdHydase_lsu_aba_2.
DR   InterPro; IPR006249; Aconitase/IRP2.
DR   InterPro; IPR018136; Aconitase_4Fe-4S_BS.
DR   InterPro; IPR000573; AconitaseA/IPMdHydase_ssu_swvl.
DR   PANTHER; PTHR11670; PTHR11670; 1.
DR   Pfam; PF00330; Aconitase; 1.
DR   Pfam; PF00694; Aconitase_C; 1.
DR   PRINTS; PR00415; ACONITASE.
DR   SUPFAM; SSF52016; SSF52016; 1.
DR   SUPFAM; SSF53732; SSF53732; 1.
DR   TIGRFAMs; TIGR01341; aconitase_1; 1.
DR   PROSITE; PS01244; ACONITASE_2; 1.
PE   3: Inferred from homology;
DR   PRODOM; Q3IFL7.
DR   SWISS-2DPAGE; Q3IFL7.
KW   4Fe-4S {ECO:0000256|RuleBase:RU361275};
KW   Complete proteome {ECO:0000313|Proteomes:UP000006843};
KW   Iron {ECO:0000256|RuleBase:RU361275};
KW   Iron-sulfur {ECO:0000256|RuleBase:RU361275};
KW   Lyase {ECO:0000256|RuleBase:RU361275, ECO:0000256|SAAS:SAAS00638284,
KW   ECO:0000313|EMBL:CAI85263.1};
KW   Metal-binding {ECO:0000256|RuleBase:RU361275};
KW   Reference proteome {ECO:0000313|Proteomes:UP000006843}.
FT   DOMAIN       64    586       Aconitase. {ECO:0000259|Pfam:PF00330}.
FT   DOMAIN      717    843       Aconitase_C. {ECO:0000259|Pfam:PF00694}.
SQ   SEQUENCE   914 AA;  100021 MW;  249797F0D1B02102 CRC64;
     MNNSFKTQQQ LTVNGEQFHI HSLKGLGDKA KRLPFSLKIL LENLLRNEDG ENIKEQDIQA
     LLDWDPQAKP SAEVAFTPAR VVMQDFTGVP AIVDLAAMRD AMEKLGGDPA KINPLSPAEL
     VIDHSVQVDG YGNEGAFDLN AKLEYDRNKE RYEFLRWGQT AFDNLKVVPP ATGIVHQVNL
     EYLARVVFND ERNGQKYAYP DTLVGTDSHT TMINGLGVLG WGVGGIEAEA AMLGQPISLL
     IPQVVGVKLN GRLPEGTTAT DLVLTVTEML RNHGVVGKFV EFYGDGLADL PLADRATIAN
     MAPEYGATCG IFPIDDETIN YLRLTNRDEK QLKLIEDYAK HQGLWRNDGD EANYTDKLEL
     ILDDVVPSLA GPKRPQDRIS LDKAGEAISQ HLKEFQDERL AKISSSDTEQ ARIESEGPVT
     NPDESSNEAP FIGAAKVNFK GQEFELKDGA CVIAAITSCT NTSNPSVILA AGLVAKKAKQ
     LGINVKPWVK TSLAPGSKVV TDYLEKAGLM DDLESLGFNL VGYGCTTCIG NSGPLAPEIS
     DAIQKHKLVV SSILSGNRNF EGRIHQDVKM NFLASPPLVV AYAIAGRTDI DVYNEPLAQD
     ANGNDIYLKN IWPSVKEVSD LVKETVTREM FEKSYANVYE GDSRWQKIQI PDGKLYDWDD
     ASTYIKKAPF FDGMSIEPPG IPTITGARCL AKLGDSVTTD HISPAGAIKA DSPAGLYLQD
     NKVGQAQFNS YGSRRGNHEV MMRGTFANIR LKNLLAPGTE GGVTRTQPDD ELASIYDAAM
     EYQKNDTPLV ILAGKEYGTG SSRDWAAKGS LLLGVKAVIA QSYERIHRSN LIGMGVLPLQ
     FKDGESHESL GLTGQEQFDI EGLFDKTKEV SVIATNSEGK KVSFSADVRI DTPKEWDYYK
     HGGILQYVLR NMLD
//

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