(data stored in ACNUC7421 zone)

SWISSPROT: MUTL_PSEHT

ID   MUTL_PSEHT              Reviewed;         618 AA.
AC   Q3IDU0;
DT   26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   08-NOV-2005, sequence version 1.
DT   07-JUN-2017, entry version 79.
DE   RecName: Full=DNA mismatch repair protein MutL {ECO:0000255|HAMAP-Rule:MF_00149};
GN   Name=mutL {ECO:0000255|HAMAP-Rule:MF_00149};
GN   OrderedLocusNames=PSHAa0269;
OS   Pseudoalteromonas haloplanktis (strain TAC 125).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Alteromonadales;
OC   Pseudoalteromonadaceae; Pseudoalteromonas.
OX   NCBI_TaxID=326442;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=TAC 125;
RX   PubMed=16169927; DOI=10.1101/gr.4126905;
RA   Medigue C., Krin E., Pascal G., Barbe V., Bernsel A., Bertin P.N.,
RA   Cheung F., Cruveiller S., D'Amico S., Duilio A., Fang G., Feller G.,
RA   Ho C., Mangenot S., Marino G., Nilsson J., Parrilli E., Rocha E.P.C.,
RA   Rouy Z., Sekowska A., Tutino M.L., Vallenet D., von Heijne G.,
RA   Danchin A.;
RT   "Coping with cold: the genome of the versatile marine Antarctica
RT   bacterium Pseudoalteromonas haloplanktis TAC125.";
RL   Genome Res. 15:1325-1335(2005).
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in
CC       DNA. It is required for dam-dependent methyl-directed DNA mismatch
CC       repair. May act as a "molecular matchmaker", a protein that
CC       promotes the formation of a stable complex between two or more
CC       DNA-binding proteins in an ATP-dependent manner without itself
CC       being part of a final effector complex. {ECO:0000255|HAMAP-
CC       Rule:MF_00149}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutL/HexB family.
CC       {ECO:0000255|HAMAP-Rule:MF_00149}.
DR   EMBL; CR954246; CAI85368.1; -; Genomic_DNA.
DR   RefSeq; WP_011326982.1; NC_007481.1.
DR   ProteinModelPortal; Q3IDU0; -.
DR   SMR; Q3IDU0; -.
DR   STRING; 326442.PSHAa0269; -.
DR   EnsemblBacteria; CAI85368; CAI85368; PSHAa0269.
DR   KEGG; pha:PSHAa0269; -.
DR   PATRIC; fig|326442.8.peg.256; -.
DR   eggNOG; ENOG4105DC6; Bacteria.
DR   eggNOG; COG0323; LUCA.
DR   HOGENOM; HOG000256551; -.
DR   KO; K03572; -.
DR   OMA; ITLTHNE; -.
DR   OrthoDB; POG091H015A; -.
DR   Proteomes; UP000006843; Chromosome I.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:InterPro.
DR   Gene3D; 3.30.230.10; -; 1.
DR   Gene3D; 3.30.565.10; -; 1.
DR   HAMAP; MF_00149; DNA_mis_repair; 1.
DR   InterPro; IPR013507; DNA_mismatch_repair_C.
DR   InterPro; IPR014762; DNA_mismatch_repair_CS.
DR   InterPro; IPR002099; DNA_mismatch_repair_fam.
DR   InterPro; IPR020667; DNA_mismatch_repair_MutL.
DR   InterPro; IPR003594; HATPase_C.
DR   InterPro; IPR014790; MutL_C.
DR   InterPro; IPR020568; Ribosomal_S5_D2-typ_fold.
DR   InterPro; IPR014721; Ribosomal_S5_D2-typ_fold_subgr.
DR   Pfam; PF01119; DNA_mis_repair; 1.
DR   Pfam; PF08676; MutL_C; 1.
DR   SMART; SM01340; DNA_mis_repair; 1.
DR   SUPFAM; SSF54211; SSF54211; 1.
DR   SUPFAM; SSF55874; SSF55874; 1.
DR   TIGRFAMs; TIGR00585; mutl; 1.
DR   PROSITE; PS00058; DNA_MISMATCH_REPAIR_1; 1.
PE   3: Inferred from homology;
DR   PRODOM; Q3IDU0.
DR   SWISS-2DPAGE; Q3IDU0.
KW   Complete proteome; DNA damage; DNA repair; Reference proteome.
FT   CHAIN         1    618       DNA mismatch repair protein MutL.
FT                                /FTId=PRO_1000071508.
SQ   SEQUENCE   618 AA;  68414 MW;  48F687DB922A6DA7 CRC64;
     MSIEILPARL ANQIAAGEVV ERPASVVKEL VENSLDAGAT RIQIDIERGG HKLIRIRDNG
     AGIAQDELTL ALSRHATSKL KSLDDLENIC SLGFRGEALA SISSVSRLTL SSKTKHQEAA
     WQAFAQGRDM AVQVKPVAHP DGTTIEVKDL FFNTPARRKF LRTEKTEFSH IDELIKRIAL
     SRFDVSITLT HNEKVVRQYR AKTDPSQAIA RVAQVAGKAF AEQGLHIQSG EGGLQLHGWV
     LPVGSANTVQ YTYVNNRMMR DKLILHAIRQ AFEEVSGAQE LPGFVIYIDI DPRQVDVNVH
     PAKHEVRFHQ GRLVHDFILQ AIKQVVVPLQ GEFTNEPLNN LADTAFSQTD TARSPTGNFE
     SGEVFDYPKS QLQPSHSVSS GGASLGSRSA GGSGGAYRAT PSTNHHDINA FYQGVSEQHA
     AHFDQGAHVS VGVNQSHAVE QAVALKTVAI ISINEGVCVF SSEQQLYCSH FKYALVDDWH
     EQIKEQGSLE GKALLLPVRV NLSKQDCELI AAQQSWFTLL GFELIIEKQF VMVKKLPACL
     YLLDVTSAVE SLLEACKAPL ENIESWLAWQ MQHTPARFYS SNIFLAQQAR MQNNPQTIER
     LRVKAVKIDI EHYLMQLD
//

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