(data stored in ACNUC7421 zone)

SWISSPROT: QUEA_PSEHT

ID   QUEA_PSEHT              Reviewed;         343 AA.
AC   Q3ILB9;
DT   04-APR-2006, integrated into UniProtKB/Swiss-Prot.
DT   08-NOV-2005, sequence version 1.
DT   07-JUN-2017, entry version 70.
DE   RecName: Full=S-adenosylmethionine:tRNA ribosyltransferase-isomerase {ECO:0000255|HAMAP-Rule:MF_00113};
DE            EC=2.4.99.17 {ECO:0000255|HAMAP-Rule:MF_00113};
DE   AltName: Full=Queuosine biosynthesis protein QueA {ECO:0000255|HAMAP-Rule:MF_00113};
GN   Name=queA {ECO:0000255|HAMAP-Rule:MF_00113};
GN   OrderedLocusNames=PSHAa0318;
OS   Pseudoalteromonas haloplanktis (strain TAC 125).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Alteromonadales;
OC   Pseudoalteromonadaceae; Pseudoalteromonas.
OX   NCBI_TaxID=326442;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=TAC 125;
RX   PubMed=16169927; DOI=10.1101/gr.4126905;
RA   Medigue C., Krin E., Pascal G., Barbe V., Bernsel A., Bertin P.N.,
RA   Cheung F., Cruveiller S., D'Amico S., Duilio A., Fang G., Feller G.,
RA   Ho C., Mangenot S., Marino G., Nilsson J., Parrilli E., Rocha E.P.C.,
RA   Rouy Z., Sekowska A., Tutino M.L., Vallenet D., von Heijne G.,
RA   Danchin A.;
RT   "Coping with cold: the genome of the versatile marine Antarctica
RT   bacterium Pseudoalteromonas haloplanktis TAC125.";
RL   Genome Res. 15:1325-1335(2005).
CC   -!- FUNCTION: Transfers and isomerizes the ribose moiety from AdoMet
CC       to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give
CC       epoxyqueuosine (oQ-tRNA). {ECO:0000255|HAMAP-Rule:MF_00113}.
CC   -!- CATALYTIC ACTIVITY: S-adenosyl-L-methionine + 7-aminomethyl-7-
CC       carbaguanosine(34) in tRNA = L-methionine + adenine +
CC       epoxyqueuosine(34) in tRNA. {ECO:0000255|HAMAP-Rule:MF_00113}.
CC   -!- PATHWAY: tRNA modification; tRNA-queuosine biosynthesis.
CC       {ECO:0000255|HAMAP-Rule:MF_00113}.
CC   -!- SUBUNIT: Monomer. {ECO:0000255|HAMAP-Rule:MF_00113}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00113}.
CC   -!- SIMILARITY: Belongs to the QueA family. {ECO:0000255|HAMAP-
CC       Rule:MF_00113}.
DR   EMBL; CR954246; CAI85417.1; -; Genomic_DNA.
DR   RefSeq; WP_011327031.1; NC_007481.1.
DR   ProteinModelPortal; Q3ILB9; -.
DR   SMR; Q3ILB9; -.
DR   STRING; 326442.PSHAa0318; -.
DR   EnsemblBacteria; CAI85417; CAI85417; PSHAa0318.
DR   KEGG; pha:PSHAa0318; -.
DR   PATRIC; fig|326442.8.peg.304; -.
DR   eggNOG; ENOG4105E2N; Bacteria.
DR   eggNOG; COG0809; LUCA.
DR   HOGENOM; HOG000004402; -.
DR   KO; K07568; -.
DR   OMA; YSYGDGM; -.
DR   OrthoDB; POG091H00ZG; -.
DR   UniPathway; UPA00392; -.
DR   Proteomes; UP000006843; Chromosome I.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0016853; F:isomerase activity; IEA:InterPro.
DR   GO; GO:0016740; F:transferase activity; IEA:UniProtKB-KW.
DR   GO; GO:0008616; P:queuosine biosynthetic process; IEA:UniProtKB-UniPathway.
DR   HAMAP; MF_00113; QueA; 1.
DR   InterPro; IPR003699; QueA.
DR   Pfam; PF02547; Queuosine_synth; 1.
DR   SUPFAM; SSF111337; SSF111337; 1.
DR   TIGRFAMs; TIGR00113; queA; 1.
PE   3: Inferred from homology;
DR   PRODOM; Q3ILB9.
DR   SWISS-2DPAGE; Q3ILB9.
KW   Complete proteome; Cytoplasm; Queuosine biosynthesis;
KW   Reference proteome; S-adenosyl-L-methionine; Transferase.
FT   CHAIN         1    343       S-adenosylmethionine:tRNA
FT                                ribosyltransferase-isomerase.
FT                                /FTId=PRO_0000231358.
SQ   SEQUENCE   343 AA;  37984 MW;  EB4A0FC0C9E1E12C CRC64;
     MRVADFSFDL PDELIARFPK QDRTSSRLLS LDGPSGVVEH KVFSDLLELV NENDLLVFNN
     TRVIPARMFG QKASGGKVEV LVERVLDEHR VLAHVRASKS LKPGNEVILE GKAKATMVAR
     HDTLFELEFE HSQNVLDILN DIGHMPLPPY IDRPDNEADR ERYQTVYGEK PGAVAAPTAG
     LHFDDKLMTA LKNKGVQMAF VTLHVGAGTF QPVRVATVDE HIMHSEYIEV PDDVVAAVAN
     TKANGGRVIA IGTTSVRSLE SAAKVHGGKL DTYFGDTDIF IYPGYQFNVV DAMITNFHLP
     ESTLIMLVSA FAGQNNIMGA YNTAIEQQYR FFSYGDAMFL TRK
//

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