(data stored in ACNUC7421 zone)

SWISSPROT: Q3IFR4_PSEHT

ID   Q3IFR4_PSEHT            Unreviewed;       367 AA.
AC   Q3IFR4;
DT   08-NOV-2005, integrated into UniProtKB/TrEMBL.
DT   08-NOV-2005, sequence version 1.
DT   07-JUN-2017, entry version 96.
DE   RecName: Full=Phosphoribosylaminoimidazole-succinocarboxamide synthase {ECO:0000256|HAMAP-Rule:MF_00137};
DE            EC=6.3.2.6 {ECO:0000256|HAMAP-Rule:MF_00137};
DE   AltName: Full=SAICAR synthetase {ECO:0000256|HAMAP-Rule:MF_00137};
GN   Name=purC {ECO:0000256|HAMAP-Rule:MF_00137,
GN   ECO:0000313|EMBL:CAI85551.1};
GN   OrderedLocusNames=PSHAa0454 {ECO:0000313|EMBL:CAI85551.1};
OS   Pseudoalteromonas haloplanktis (strain TAC 125).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Alteromonadales;
OC   Pseudoalteromonadaceae; Pseudoalteromonas.
OX   NCBI_TaxID=326442 {ECO:0000313|EMBL:CAI85551.1, ECO:0000313|Proteomes:UP000006843};
RN   [1] {ECO:0000313|EMBL:CAI85551.1, ECO:0000313|Proteomes:UP000006843}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=TAC 125 {ECO:0000313|Proteomes:UP000006843};
RX   PubMed=16169927; DOI=10.1101/gr.4126905;
RA   Medigue C., Krin E., Pascal G., Barbe V., Bernsel A., Bertin P.,
RA   Cheung F., Cruveiller S., Damico S., Duilio A., Fang G., Feller G.,
RA   Mangenot S., Marino G., Nilsson J., Parilli E., Rocha E., Rouy Z.,
RA   Sekowska A., Tutino M.L., Vallenet D., von Heijne G., Danchin A.;
RT   "Coping with cold: the genome of the versatile marine Antarctica
RT   bacterium Pseudoalteromonas haloplanktis TAC125.";
RL   Genome Res. 15:1325-1335(2005).
CC   -!- CATALYTIC ACTIVITY: ATP + 5-amino-1-(5-phospho-D-
CC       ribosyl)imidazole-4-carboxylate + L-aspartate = ADP + phosphate +
CC       (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-
CC       carboxamido)succinate. {ECO:0000256|HAMAP-Rule:MF_00137,
CC       ECO:0000256|SAAS:SAAS00337907}.
CC   -!- PATHWAY: Purine metabolism; IMP biosynthesis via de novo pathway;
CC       5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-
CC       amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate: step 1/2.
CC       {ECO:0000256|HAMAP-Rule:MF_00137, ECO:0000256|SAAS:SAAS00337887}.
CC   -!- SIMILARITY: Belongs to the SAICAR synthetase family.
CC       {ECO:0000256|HAMAP-Rule:MF_00137, ECO:0000256|SAAS:SAAS00535425}.
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DR   EMBL; CR954246; CAI85551.1; -; Genomic_DNA.
DR   RefSeq; WP_011327164.1; NC_007481.1.
DR   ProteinModelPortal; Q3IFR4; -.
DR   STRING; 326442.PSHAa0454; -.
DR   EnsemblBacteria; CAI85551; CAI85551; PSHAa0454.
DR   KEGG; pha:PSHAa0454; -.
DR   PATRIC; fig|326442.8.peg.431; -.
DR   eggNOG; ENOG4105C8V; Bacteria.
DR   eggNOG; COG0152; LUCA.
DR   HOGENOM; HOG000230361; -.
DR   KO; K01923; -.
DR   OMA; EMVIRGY; -.
DR   OrthoDB; POG091H01GT; -.
DR   UniPathway; UPA00074; UER00131.
DR   Proteomes; UP000006843; Chromosome I.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0004639; F:phosphoribosylaminoimidazolesuccinocarboxamide synthase activity; IEA:UniProtKB-HAMAP.
DR   GO; GO:0006189; P:'de novo' IMP biosynthetic process; IEA:UniProtKB-HAMAP.
DR   HAMAP; MF_00137; SAICAR_synth; 1.
DR   InterPro; IPR028923; SAICAR_synt/ADE2_N.
DR   InterPro; IPR014106; SAICAR_synthase_Vibrio-typ.
DR   Pfam; PF01259; SAICAR_synt; 1.
DR   TIGRFAMs; TIGR02735; purC_vibrio; 1.
PE   3: Inferred from homology;
DR   PRODOM; Q3IFR4.
DR   SWISS-2DPAGE; Q3IFR4.
KW   ATP-binding {ECO:0000256|HAMAP-Rule:MF_00137,
KW   ECO:0000256|SAAS:SAAS00416489};
KW   Complete proteome {ECO:0000313|Proteomes:UP000006843};
KW   Ligase {ECO:0000256|HAMAP-Rule:MF_00137,
KW   ECO:0000256|SAAS:SAAS00416508, ECO:0000313|EMBL:CAI85551.1};
KW   Nucleotide-binding {ECO:0000256|HAMAP-Rule:MF_00137,
KW   ECO:0000256|SAAS:SAAS00416561};
KW   Purine biosynthesis {ECO:0000256|HAMAP-Rule:MF_00137,
KW   ECO:0000256|SAAS:SAAS00416526};
KW   Reference proteome {ECO:0000313|Proteomes:UP000006843}.
FT   DOMAIN       21    294       SAICAR_synt. {ECO:0000259|Pfam:PF01259}.
SQ   SEQUENCE   367 AA;  40728 MW;  15680279EBB5DD97 CRC64;
     MTSYKVLDVN DDLPIRTKGD VHSGKVRSVY WLTDADSKRL ISEKGYKVPA DTELAIMVIS
     DRISAFDCIW QGENGLNGVP GKGIALNSVA AHWFKLFDEA GLAGNHIVDI PHPYVWIVRK
     ASTVKVEAIA RQYITGSMWR DYAKGVRDFC GINLPEGLTA NQKLDKVLIT PSTKGIITGV
     ADIPPVDDVN ITRSNITNNL SVFNFRAADD VAQYEKLLVE GFELISGELA KLGQIFVDTK
     FEFGYVEDIN GAEQLIYIDE VGTPDSSRIW DEASYKDGKI VENSKEGFRQ LLINNVPESD
     VLLNKDRMDE REQLAKDYIL PESVMLEVSN TYVGIASKIV GKEIVIPADP RQEVIAILDA
     DYGLIIK
//

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