(data stored in ACNUC7421 zone)

SWISSPROT: Q3ILJ0_PSEHT

ID   Q3ILJ0_PSEHT            Unreviewed;       352 AA.
AC   Q3ILJ0;
DT   08-NOV-2005, integrated into UniProtKB/TrEMBL.
DT   08-NOV-2005, sequence version 1.
DT   08-MAY-2019, entry version 89.
DE   RecName: Full=Adenine DNA glycosylase {ECO:0000256|RuleBase:RU365096};
DE            EC=3.2.2.31 {ECO:0000256|RuleBase:RU365096};
GN   Name=mutY {ECO:0000313|EMBL:CAI85642.1};
GN   OrderedLocusNames=PSHAa0554 {ECO:0000313|EMBL:CAI85642.1};
OS   Pseudoalteromonas haloplanktis (strain TAC 125).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Alteromonadales;
OC   Pseudoalteromonadaceae; Pseudoalteromonas.
OX   NCBI_TaxID=326442 {ECO:0000313|EMBL:CAI85642.1, ECO:0000313|Proteomes:UP000006843};
RN   [1] {ECO:0000313|EMBL:CAI85642.1, ECO:0000313|Proteomes:UP000006843}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=TAC 125 {ECO:0000313|Proteomes:UP000006843};
RX   PubMed=16169927; DOI=10.1101/gr.4126905;
RA   Medigue C., Krin E., Pascal G., Barbe V., Bernsel A., Bertin P.,
RA   Cheung F., Cruveiller S., Damico S., Duilio A., Fang G., Feller G.,
RA   Mangenot S., Marino G., Nilsson J., Parilli E., Rocha E., Rouy Z.,
RA   Sekowska A., Tutino M.L., Vallenet D., von Heijne G., Danchin A.;
RT   "Coping with cold: the genome of the versatile marine Antarctica
RT   bacterium Pseudoalteromonas haloplanktis TAC125.";
RL   Genome Res. 15:1325-1335(2005).
CC   -!- FUNCTION: Adenine glycosylase active on G-A mispairs.
CC       {ECO:0000256|RuleBase:RU365096}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=Hydrolyzes free adenine bases from 7,8-dihydro-8-
CC         oxoguanine:adenine mismatched double-stranded DNA, leaving an
CC         apurinic site.; EC=3.2.2.31;
CC         Evidence={ECO:0000256|RuleBase:RU365096};
CC   -!- COFACTOR:
CC       Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883;
CC         Evidence={ECO:0000256|RuleBase:RU365096};
CC       Note=Binds 1 [4Fe-4S] cluster. {ECO:0000256|RuleBase:RU365096};
CC   -!- SIMILARITY: Belongs to the Nth/MutY family.
CC       {ECO:0000256|RuleBase:RU365096}.
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DR   EMBL; CR954246; CAI85642.1; -; Genomic_DNA.
DR   STRING; 326442.PSHAa0554; -.
DR   EnsemblBacteria; CAI85642; CAI85642; PSHAa0554.
DR   KEGG; pha:PSHAa0554; -.
DR   eggNOG; ENOG4105CEN; Bacteria.
DR   eggNOG; COG1194; LUCA.
DR   HOGENOM; HOG000028744; -.
DR   KO; K03575; -.
DR   OMA; RDPYRVW; -.
DR   Proteomes; UP000006843; Chromosome I.
DR   GO; GO:0051539; F:4 iron, 4 sulfur cluster binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0019104; F:DNA N-glycosylase activity; IEA:InterPro.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0006284; P:base-excision repair; IEA:UniProtKB-UniRule.
DR   CDD; cd03431; DNA_Glycosylase_C; 1.
DR   CDD; cd00056; ENDO3c; 1.
DR   Gene3D; 1.10.1670.10; -; 1.
DR   InterPro; IPR005760; A/G_AdeGlyc_MutY.
DR   InterPro; IPR011257; DNA_glycosylase.
DR   InterPro; IPR004036; Endonuclease-III-like_CS2.
DR   InterPro; IPR003265; HhH-GPD_domain.
DR   InterPro; IPR000445; HhH_motif.
DR   InterPro; IPR023170; HTH_base_excis_C.
DR   InterPro; IPR029119; MutY_C.
DR   InterPro; IPR015797; NUDIX_hydrolase-like_dom_sf.
DR   Pfam; PF00633; HHH; 1.
DR   Pfam; PF00730; HhH-GPD; 1.
DR   Pfam; PF14815; NUDIX_4; 1.
DR   SMART; SM00478; ENDO3c; 1.
DR   SUPFAM; SSF48150; SSF48150; 1.
DR   SUPFAM; SSF55811; SSF55811; 1.
DR   TIGRFAMs; TIGR01084; mutY; 1.
DR   PROSITE; PS01155; ENDONUCLEASE_III_2; 1.
PE   3: Inferred from homology;
DR   PRODOM; Q3ILJ0.
DR   SWISS-2DPAGE; Q3ILJ0.
KW   Complete proteome {ECO:0000313|Proteomes:UP000006843};
KW   DNA damage {ECO:0000256|RuleBase:RU365096};
KW   Glycosidase {ECO:0000256|RuleBase:RU365096,
KW   ECO:0000313|EMBL:CAI85642.1};
KW   Hydrolase {ECO:0000313|EMBL:CAI85642.1};
KW   Iron {ECO:0000256|RuleBase:RU365096};
KW   Reference proteome {ECO:0000313|Proteomes:UP000006843}.
FT   DOMAIN       44    195       ENDO3c. {ECO:0000259|SMART:SM00478}.
SQ   SEQUENCE   352 AA;  40073 MW;  19A6A2F4C699AF42 CRC64;
     MDLNKQQSDW FSNQVVDWYH LHGRKTLPWQ LAKTPYKVWV SEVMLQQTQV VTVIPYFERF
     MQSFPDIIAL ANADEDQVLH HWTGLGYYAR ARNLHKTAKI VRDKYQGQFP TTLEEVIDLP
     GIGRSTAGAV LSLSLGQHHP ILDGNVKRVL ARFFMVEGWY GVKKVESQLW HLSEQLTPKN
     NVTEFNQAMM DLGSSLCSRS RFDCPACPLS SRCGAFKTQQ VKTFPHSKPK KAVPKKSCHQ
     LIIKHDDKVL MEKRPNSGIW GGLFGFFEFN ELSELEVFIA QQGLTADLVA LEPFTHIFSH
     FELTINPHVL NIVQIPDVIN DRQLVWYPLA QSIEVGLAAP TKKLVKQIAP IG
//

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