(data stored in ACNUC9435 zone)

SWISSPROT: HPDS_CLOD6

ID   HPDS_CLOD6              Reviewed;          85 AA.
AC   Q18CP4;
DT   11-JAN-2011, integrated into UniProtKB/Swiss-Prot.
DT   25-JUL-2006, sequence version 1.
DT   11-DEC-2019, entry version 54.
DE   RecName: Full=4-hydroxyphenylacetate decarboxylase small subunit {ECO:0000250|UniProtKB:Q84F15};
DE            EC=4.1.1.83;
DE   AltName: Full=p-hydroxyphenylacetate decarboxylase small subunit {ECO:0000250|UniProtKB:Q84F15};
GN   Name=hpdC {ECO:0000312|EMBL:CAJ66974.1}; OrderedLocusNames=CD630_01540;
OS   Clostridioides difficile (strain 630) (Peptoclostridium difficile).
OC   Bacteria; Firmicutes; Clostridia; Clostridiales; Peptostreptococcaceae;
OC   Clostridioides.
OX   NCBI_TaxID=272563;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=630;
RX   PubMed=16804543; DOI=10.1038/ng1830;
RA   Sebaihia M., Wren B.W., Mullany P., Fairweather N.F., Minton N.,
RA   Stabler R., Thomson N.R., Roberts A.P., Cerdeno-Tarraga A.M., Wang H.,
RA   Holden M.T.G., Wright A., Churcher C., Quail M.A., Baker S., Bason N.,
RA   Brooks K., Chillingworth T., Cronin A., Davis P., Dowd L., Fraser A.,
RA   Feltwell T., Hance Z., Holroyd S., Jagels K., Moule S., Mungall K.,
RA   Price C., Rabbinowitsch E., Sharp S., Simmonds M., Stevens K., Unwin L.,
RA   Whithead S., Dupuy B., Dougan G., Barrell B., Parkhill J.;
RT   "The multidrug-resistant human pathogen Clostridium difficile has a highly
RT   mobile, mosaic genome.";
RL   Nat. Genet. 38:779-786(2006).
CC   -!- FUNCTION: Decarboxylates phenylacetates with a hydroxyl group in the p-
CC       position. Active toward 4-hydroxyphenylacetate, 3,4-
CC       dihydroxyphenylacetate and p-hydroxymandelate, forming 4-methylphenol,
CC       4-methylcatechol and p-hydroxybenzylalcohol respectively (By
CC       similarity). {ECO:0000250|UniProtKB:Q84F15}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=4-hydroxyphenylacetate + H(+) = 4-methylphenol + CO2;
CC         Xref=Rhea:RHEA:22732, ChEBI:CHEBI:15378, ChEBI:CHEBI:16526,
CC         ChEBI:CHEBI:17847, ChEBI:CHEBI:48999; EC=4.1.1.83;
CC         Evidence={ECO:0000250|UniProtKB:Q84F15};
CC   -!- COFACTOR:
CC       Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883;
CC         Evidence={ECO:0000250|UniProtKB:Q84F15};
CC       Note=Binds 4 to 6 [4Fe-4S] clusters per heterooctamer.
CC       {ECO:0000250|UniProtKB:Q84F15};
CC   -!- ACTIVITY REGULATION: Activated by the 4-hydroxyphenylacetate
CC       decarboxylase activating enzyme. {ECO:0000250|UniProtKB:Q84F15}.
CC   -!- SUBUNIT: Heterooctamer consisting of 4 large (HpdB) subunits and 4
CC       small (HpdC) subunits. {ECO:0000250}.
CC   -!- PTM: Phosphorylated on serine. Phosphorylation may trigger the
CC       formation of the active heterooctamers (By similarity).
CC       {ECO:0000250|UniProtKB:Q84F15}.
DR   EMBL; AM180355; CAJ66974.1; -; Genomic_DNA.
DR   RefSeq; WP_003425410.1; NZ_CP010905.2.
DR   RefSeq; YP_001086623.1; NC_009089.1.
DR   SMR; Q18CP4; -.
DR   STRING; 272563.CD630_01540; -.
DR   EnsemblBacteria; CAJ66974; CAJ66974; CD630_01540.
DR   GeneID; 4914360; -.
DR   KEGG; cdf:CD630_01540; -.
DR   KEGG; pdc:CDIF630_00273; -.
DR   PATRIC; fig|272563.120.peg.167; -.
DR   eggNOG; ENOG410782T; Bacteria.
DR   eggNOG; ENOG410Z529; LUCA.
DR   HOGENOM; HOG000061466; -.
DR   KO; K18428; -.
DR   OMA; ANDEGIG; -.
DR   Proteomes; UP000001978; Chromosome.
DR   GO; GO:0051539; F:4 iron, 4 sulfur cluster binding; IEA:UniProtKB-KW.
DR   GO; GO:0043722; F:4-hydroxyphenylacetate decarboxylase activity; IEA:UniProtKB-EC.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   InterPro; IPR041125; 4HPAD_g_N.
DR   InterPro; IPR040923; HpdC_C.
DR   Pfam; PF18671; 4HPAD_g_N; 1.
DR   Pfam; PF18524; HPIP_like; 1.
PE   3: Inferred from homology;
DR   PRODOM; Q18CP4.
DR   SWISS-2DPAGE; Q18CP4.
KW   4Fe-4S; Iron; Iron-sulfur; Lyase; Metal-binding; Phosphoprotein;
KW   Reference proteome.
FT   CHAIN           1..85
FT                   /note="4-hydroxyphenylacetate decarboxylase small subunit"
FT                   /id="PRO_0000403692"
SQ   SEQUENCE   85 AA;  9504 MW;  1CB09CC84B155CD5 CRC64;
     MRKHSDCMNF CAVDATKGIC RLSKQMINLD DAACPEIKVM PKCKNCKNFV EANDEGIGKC
     VGLEKEDWVY STLNAITCEG HVFNE
//

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