(data stored in ACNUC29543 zone)

SWISSPROT: NU4C_SYNR3

ID   NU4C_SYNR3              Reviewed;         544 AA.
AC   A5GQH5;
DT   01-JUL-2008, integrated into UniProtKB/Swiss-Prot.
DT   12-JUN-2007, sequence version 1.
DT   08-MAY-2019, entry version 61.
DE   RecName: Full=NAD(P)H-quinone oxidoreductase chain 4 {ECO:0000255|HAMAP-Rule:MF_00491};
DE            EC=7.1.1.- {ECO:0000255|HAMAP-Rule:MF_00491};
DE   AltName: Full=NAD(P)H dehydrogenase I, chain 4 {ECO:0000255|HAMAP-Rule:MF_00491};
DE   AltName: Full=NDH-1, chain 4 {ECO:0000255|HAMAP-Rule:MF_00491};
GN   Name=ndhD {ECO:0000255|HAMAP-Rule:MF_00491};
GN   OrderedLocusNames=SynRCC307_0231;
OS   Synechococcus sp. (strain RCC307).
OC   Bacteria; Cyanobacteria; Synechococcales; Synechococcaceae;
OC   Synechococcus.
OX   NCBI_TaxID=316278;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=RCC307;
RG   Genoscope;
RL   Submitted (MAY-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: NDH-1 shuttles electrons from NAD(P)H, via FMN and iron-
CC       sulfur (Fe-S) centers, to quinones in the respiratory chain. The
CC       immediate electron acceptor for the enzyme in this species is
CC       believed to be plastoquinone. Couples the redox reaction to proton
CC       translocation (for every two electrons transferred, four hydrogen
CC       ions are translocated across the cytoplasmic membrane), and thus
CC       conserves the redox energy in a proton gradient.
CC       {ECO:0000255|HAMAP-Rule:MF_00491}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a plastoquinone + (n+1) H(+)(in) + NADH = a plastoquinol
CC         + n H(+)(out) + NAD(+); Xref=Rhea:RHEA:42608, Rhea:RHEA-
CC         COMP:9561, Rhea:RHEA-COMP:9562, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:17757, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945,
CC         ChEBI:CHEBI:62192; Evidence={ECO:0000255|HAMAP-Rule:MF_00491};
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a plastoquinone + (n+1) H(+)(in) + NADPH = a plastoquinol
CC         + n H(+)(out) + NADP(+); Xref=Rhea:RHEA:42612, Rhea:RHEA-
CC         COMP:9561, Rhea:RHEA-COMP:9562, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:17757, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349,
CC         ChEBI:CHEBI:62192; Evidence={ECO:0000255|HAMAP-Rule:MF_00491};
CC   -!- SUBCELLULAR LOCATION: Cellular thylakoid membrane
CC       {ECO:0000255|HAMAP-Rule:MF_00491}; Multi-pass membrane protein
CC       {ECO:0000255|HAMAP-Rule:MF_00491}.
CC   -!- SIMILARITY: Belongs to the complex I subunit 4 family.
CC       {ECO:0000255|HAMAP-Rule:MF_00491}.
DR   EMBL; CT978603; CAK27134.1; -; Genomic_DNA.
DR   STRING; 316278.SynRCC307_0231; -.
DR   EnsemblBacteria; CAK27134; CAK27134; SynRCC307_0231.
DR   KEGG; syr:SynRCC307_0231; -.
DR   eggNOG; ENOG4105C8S; Bacteria.
DR   eggNOG; COG1008; LUCA.
DR   HOGENOM; HOG000100683; -.
DR   KO; K05575; -.
DR   OMA; ITRWGNQ; -.
DR   Proteomes; UP000001115; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0042651; C:thylakoid membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; IEA:InterPro.
DR   GO; GO:0048038; F:quinone binding; IEA:UniProtKB-KW.
DR   GO; GO:0042773; P:ATP synthesis coupled electron transport; IEA:InterPro.
DR   HAMAP; MF_00491; NDH1_NuoM; 1.
DR   InterPro; IPR022997; NADH_Q_OxRdtase_chain4.
DR   InterPro; IPR010227; NADH_Q_OxRdtase_chainM/4.
DR   InterPro; IPR003918; NADH_UbQ_OxRdtase.
DR   InterPro; IPR001750; ND/Mrp_mem.
DR   PANTHER; PTHR43507; PTHR43507; 1.
DR   Pfam; PF00361; Proton_antipo_M; 1.
DR   PRINTS; PR01437; NUOXDRDTASE4.
DR   TIGRFAMs; TIGR01972; NDH_I_M; 1.
PE   3: Inferred from homology;
DR   PRODOM; A5GQH5.
DR   SWISS-2DPAGE; A5GQH5.
KW   Complete proteome; Membrane; NAD; NADP; Plastoquinone; Quinone;
KW   Reference proteome; Thylakoid; Translocase; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN         1    544       NAD(P)H-quinone oxidoreductase chain 4.
FT                                /FTId=PRO_0000343261.
FT   TRANSMEM     29     49       Helical. {ECO:0000255|HAMAP-
FT                                Rule:MF_00491}.
FT   TRANSMEM     60     80       Helical. {ECO:0000255|HAMAP-
FT                                Rule:MF_00491}.
FT   TRANSMEM    115    135       Helical. {ECO:0000255|HAMAP-
FT                                Rule:MF_00491}.
FT   TRANSMEM    139    159       Helical. {ECO:0000255|HAMAP-
FT                                Rule:MF_00491}.
FT   TRANSMEM    161    181       Helical. {ECO:0000255|HAMAP-
FT                                Rule:MF_00491}.
FT   TRANSMEM    193    213       Helical. {ECO:0000255|HAMAP-
FT                                Rule:MF_00491}.
FT   TRANSMEM    234    254       Helical. {ECO:0000255|HAMAP-
FT                                Rule:MF_00491}.
FT   TRANSMEM    268    288       Helical. {ECO:0000255|HAMAP-
FT                                Rule:MF_00491}.
FT   TRANSMEM    302    322       Helical. {ECO:0000255|HAMAP-
FT                                Rule:MF_00491}.
FT   TRANSMEM    339    359       Helical. {ECO:0000255|HAMAP-
FT                                Rule:MF_00491}.
FT   TRANSMEM    360    380       Helical. {ECO:0000255|HAMAP-
FT                                Rule:MF_00491}.
FT   TRANSMEM    400    422       Helical. {ECO:0000255|HAMAP-
FT                                Rule:MF_00491}.
FT   TRANSMEM    442    462       Helical. {ECO:0000255|HAMAP-
FT                                Rule:MF_00491}.
FT   TRANSMEM    488    508       Helical. {ECO:0000255|HAMAP-
FT                                Rule:MF_00491}.
FT   COMPBIAS     10     13       Poly-Ala.
SQ   SEQUENCE   544 AA;  58530 MW;  61B05502527E84CF CRC64;
     MCVKGDAQLA AAAEISTLQP DAAKELDSFP WLTTAILLPI AASLAIPLVP DPGNGKGVRW
     YALGVSLTTF LITVGAYLNG YDPDIAGLQL RQVIPWVPDL GLGWSVGADG LSMPLILLTS
     FITTLACLAA WPVTFKPRLF FFLLLAMDGG QIAVFAVQDM LLFFLAWELE LIPVYLLLAI
     WGGKKRQYAA TKFILYTAVS SLFILLVALA MAFSGGGPVS FEYSDLAAKH LGAGFQALCY
     AGLLIAFGVK LPIVPLHTWL PDAHGEATAP VHMLLAGILL KMGGYALFRF NASMFPDAHV
     QFAPLLVVLG VVNIIYAALT SFAQRNLKRK IAYSSISHMG FVLIGIGSFS PLAASGAMLQ
     MISHGLIGAS LFFLVGATYD RTHTLQLDEM GGVGQRMRKM FAMWTACSLA SLALPGMSGF
     VSELMVFVGF ATDDAYTLPF RIVIDGAAAI GVILTPIYLL SMLREIFFGQ EKPELSDANL
     VDAEPREIYI ISCLLVPIIG IGLYPKLVTD SYRATIEQVV ARDESSMKAL TAPYLPLRSA
     PKLS
//

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