(data stored in ACNUC7421 zone)

SWISSPROT: A2Q7B4_ASPNC

ID   A2Q7B4_ASPNC            Unreviewed;       303 AA.
AC   A2Q7B4;
DT   06-MAR-2007, integrated into UniProtKB/TrEMBL.
DT   06-MAR-2007, sequence version 1.
DT   11-DEC-2019, entry version 62.
DE   RecName: Full=Transcription initiation factor IIF subunit alpha {ECO:0000256|RuleBase:RU366044};
DE   Flags: Fragment;
GN   ORFNames=An01g00040 {ECO:0000313|EMBL:CAK36849.1};
OS   Aspergillus niger (strain CBS 513.88 / FGSC A1513).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus.
OX   NCBI_TaxID=425011 {ECO:0000313|Proteomes:UP000006706};
RN   [1] {ECO:0000313|EMBL:CAK36849.1, ECO:0000313|Proteomes:UP000006706}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CBS 513.88 / FGSC A1513 {ECO:0000313|Proteomes:UP000006706};
RX   PubMed=17259976; DOI=10.1038/nbt1282;
RA   Pel H.J., de Winde J.H., Archer D.B., Dyer P.S., Hofmann G., Schaap P.J.,
RA   Turner G., de Vries R.P., Albang R., Albermann K., Andersen M.R.,
RA   Bendtsen J.D., Benen J.A., van den Berg M., Breestraat S., Caddick M.X.,
RA   Contreras R., Cornell M., Coutinho P.M., Danchin E.G., Debets A.J.,
RA   Dekker P., van Dijck P.W., van Dijk A., Dijkhuizen L., Driessen A.J.,
RA   d'Enfert C., Geysens S., Goosen C., Groot G.S., de Groot P.W.,
RA   Guillemette T., Henrissat B., Herweijer M., van den Hombergh J.P.,
RA   van den Hondel C.A., van der Heijden R.T., van der Kaaij R.M., Klis F.M.,
RA   Kools H.J., Kubicek C.P., van Kuyk P.A., Lauber J., Lu X.,
RA   van der Maarel M.J., Meulenberg R., Menke H., Mortimer M.A., Nielsen J.,
RA   Oliver S.G., Olsthoorn M., Pal K., van Peij N.N., Ram A.F., Rinas U.,
RA   Roubos J.A., Sagt C.M., Schmoll M., Sun J., Ussery D., Varga J.,
RA   Vervecken W., van de Vondervoort P.J., Wedler H., Wosten H.A., Zeng A.P.,
RA   van Ooyen A.J., Visser J., Stam H.;
RT   "Genome sequencing and analysis of the versatile cell factory Aspergillus
RT   niger CBS 513.88.";
RL   Nat. Biotechnol. 25:221-231(2007).
CC   -!- FUNCTION: TFIIF is a general transcription initiation factor that binds
CC       to RNA polymerase II and helps to recruit it to the initiation complex
CC       in collaboration with TFIIB. It promotes transcription elongation.
CC       {ECO:0000256|RuleBase:RU366044}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|RuleBase:RU366044}.
CC   -!- SIMILARITY: Belongs to the TFIIF alpha subunit family.
CC       {ECO:0000256|RuleBase:RU366044}.
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DR   EMBL; AM269948; CAK36849.1; -; Genomic_DNA.
DR   PaxDb; A2Q7B4; -.
DR   EnsemblFungi; CAK36849; CAK36849; An01g00040.
DR   Proteomes; UP000006706; Chromosome 2R.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0032968; P:positive regulation of transcription elongation from RNA polymerase II promoter; IEA:InterPro.
DR   GO; GO:0006367; P:transcription initiation from RNA polymerase II promoter; IEA:InterPro.
DR   InterPro; IPR008851; TFIIF-alpha.
DR   InterPro; IPR011039; TFIIF_interaction.
DR   PANTHER; PTHR13011; PTHR13011; 1.
DR   Pfam; PF05793; TFIIF_alpha; 1.
DR   SUPFAM; SSF50916; SSF50916; 1.
PE   3: Inferred from homology;
DR   PRODOM; A2Q7B4.
DR   SWISS-2DPAGE; A2Q7B4.
KW   DNA-binding {ECO:0000256|RuleBase:RU366044};
KW   Nucleus {ECO:0000256|RuleBase:RU366044};
KW   Transcription {ECO:0000256|RuleBase:RU366044};
KW   Transcription regulation {ECO:0000256|RuleBase:RU366044}.
FT   REGION          1..91
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          124..222
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..16
FT                   /note="Polar"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        52..72
FT                   /note="Polar"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        124..155
FT                   /note="Polyampholyte"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        169..193
FT                   /note="Polyampholyte"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   NON_TER         303
FT                   /evidence="ECO:0000313|EMBL:CAK36849.1"
SQ   SEQUENCE   303 AA;  34314 MW;  B92EC8A68A4E7B28 CRC64;
     MTTPTNDQTL KTPTGSNGPP PVRIRRPKVA DPLVRPKRRP AIRPPAPTSA ANGASRMPNS
     RPVTSSQLPG ARVEKSLNPK NDFSANGFSG PLLSENYVDY PIVTTRRALR EGLKHHIARF
     TSKKSVDPRD ESQFTRPVRL QRRDPRARPN EAHVERGQLN SKPGSEQSTQ MDELEREELE
     ARKAAREKER AENMAQIAPS VGSAPKRHNA PKQKTQQVTK TDMTPEEIAR TRIKYEEALP
     WHLEDFDNKN IWVGNYEAAL SETHAVFVLE NTGKMRMIPV EKWYRFSAKN TFKALTIEEA
     ERL
//

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