(data stored in ACNUC7421 zone)

SWISSPROT: A2Q8K6_ASPNC

ID   A2Q8K6_ASPNC            Unreviewed;       857 AA.
AC   A2Q8K6;
DT   06-MAR-2007, integrated into UniProtKB/TrEMBL.
DT   06-MAR-2007, sequence version 1.
DT   11-DEC-2019, entry version 71.
DE   SubName: Full=Aspergillus niger contig An01c0160, genomic contig {ECO:0000313|EMBL:CAK37003.1};
GN   ORFNames=An01g04680 {ECO:0000313|EMBL:CAK37003.1};
OS   Aspergillus niger (strain CBS 513.88 / FGSC A1513).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus.
OX   NCBI_TaxID=425011 {ECO:0000313|Proteomes:UP000006706};
RN   [1] {ECO:0000313|EMBL:CAK37003.1, ECO:0000313|Proteomes:UP000006706}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CBS 513.88 / FGSC A1513 {ECO:0000313|Proteomes:UP000006706};
RX   PubMed=17259976; DOI=10.1038/nbt1282;
RA   Pel H.J., de Winde J.H., Archer D.B., Dyer P.S., Hofmann G., Schaap P.J.,
RA   Turner G., de Vries R.P., Albang R., Albermann K., Andersen M.R.,
RA   Bendtsen J.D., Benen J.A., van den Berg M., Breestraat S., Caddick M.X.,
RA   Contreras R., Cornell M., Coutinho P.M., Danchin E.G., Debets A.J.,
RA   Dekker P., van Dijck P.W., van Dijk A., Dijkhuizen L., Driessen A.J.,
RA   d'Enfert C., Geysens S., Goosen C., Groot G.S., de Groot P.W.,
RA   Guillemette T., Henrissat B., Herweijer M., van den Hombergh J.P.,
RA   van den Hondel C.A., van der Heijden R.T., van der Kaaij R.M., Klis F.M.,
RA   Kools H.J., Kubicek C.P., van Kuyk P.A., Lauber J., Lu X.,
RA   van der Maarel M.J., Meulenberg R., Menke H., Mortimer M.A., Nielsen J.,
RA   Oliver S.G., Olsthoorn M., Pal K., van Peij N.N., Ram A.F., Rinas U.,
RA   Roubos J.A., Sagt C.M., Schmoll M., Sun J., Ussery D., Varga J.,
RA   Vervecken W., van de Vondervoort P.J., Wedler H., Wosten H.A., Zeng A.P.,
RA   van Ooyen A.J., Visser J., Stam H.;
RT   "Genome sequencing and analysis of the versatile cell factory Aspergillus
RT   niger CBS 513.88.";
RL   Nat. Biotechnol. 25:221-231(2007).
CC   -!- SIMILARITY: Belongs to the peptidase C2 family.
CC       {ECO:0000256|SAAS:SAAS01047719}.
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DR   EMBL; AM269963; CAK37003.1; -; Genomic_DNA.
DR   RefSeq; XP_001388895.1; XM_001388858.1.
DR   MEROPS; C02.008; -.
DR   PaxDb; A2Q8K6; -.
DR   EnsemblFungi; CAK37003; CAK37003; An01g04680.
DR   GeneID; 4978314; -.
DR   KEGG; ang:ANI_1_602014; -.
DR   HOGENOM; HOG000212111; -.
DR   Proteomes; UP000006706; Chromosome 2R.
DR   GO; GO:0004198; F:calcium-dependent cysteine-type endopeptidase activity; IEA:InterPro.
DR   CDD; cd00044; CysPc; 1.
DR   InterPro; IPR022683; Calpain_III.
DR   InterPro; IPR036213; Calpain_III_sf.
DR   InterPro; IPR007330; MIT.
DR   InterPro; IPR036181; MIT_dom_sf.
DR   InterPro; IPR038765; Papain-like_cys_pep_sf.
DR   InterPro; IPR001300; Peptidase_C2_calpain_cat.
DR   Pfam; PF00648; Peptidase_C2; 1.
DR   SMART; SM00720; calpain_III; 1.
DR   SMART; SM00230; CysPc; 1.
DR   SMART; SM00745; MIT; 1.
DR   SUPFAM; SSF116846; SSF116846; 1.
DR   SUPFAM; SSF49758; SSF49758; 2.
DR   SUPFAM; SSF54001; SSF54001; 1.
DR   PROSITE; PS50203; CALPAIN_CAT; 1.
PE   3: Inferred from homology;
DR   PRODOM; A2Q8K6.
DR   SWISS-2DPAGE; A2Q8K6.
KW   Hydrolase {ECO:0000256|PROSITE-ProRule:PRU00239};
KW   Protease {ECO:0000256|PROSITE-ProRule:PRU00239};
KW   Thiol protease {ECO:0000256|PROSITE-ProRule:PRU00239}.
FT   DOMAIN          118..441
FT                   /note="Calpain catalytic"
FT                   /evidence="ECO:0000259|PROSITE:PS50203"
FT   ACT_SITE        200
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00239"
FT   ACT_SITE        368
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00239"
FT   ACT_SITE        388
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00239"
SQ   SEQUENCE   857 AA;  95658 MW;  2CFE09BD997BFDC5 CRC64;
     MSRPNAASKK FLVNQALKAE RDASSALTQG QALESAIDAA ENYMKALSLT TESKDRQALD
     AKCKEWLTRA ERIKQDKDWQ AVLQIHEKSG LTARFPKSTR KLTTREEIIL LESAKLNGFI
     FPPWENAPGP EDFEKGDEGL FTDKPDLHLS KLQRRILAGW ERPFDLLSKH ANGIDGLKSK
     MPVMSVSGPT DLVQDMLTDC SVVASLCAAT SRSERGLDKH HLPIVFPCEY GQVNPRISPS
     GKYIFRFYFN GCFRKVVIDD RLPASKTSRS LHVVDRNHPN FLWPAFVEKA YLKLRGGYDF
     PGSNSGTDLW VLTGWIPEQV FLHQDDVTAE QLWRRLFKRF RNGDVLLTIG TGKLTEREQK
     ELGFASEHDY AILDMREQRD RRQMLVKNPW AGDDAITGDI ADSFALGHTS HTPASSLPRT
     YWMDCESVLQ NFENLYLNWN PGIFRYREDI HFAWDLSTAR GVAGCFAKNP QFAVTSEVGG
     KVWLLLGKHF RSIHHDEQTQ VPQDDLEPGF ISIYVFNANG KRVALSEGAL HRGPYVDSPN
     TLMRLEMPPG TTYTVVVSEQ SLPAVSQNFT LSALSDNPLL LAPAQNRYAC LTKTQGLWMP
     STAGGNAESA RYPFNPQFRL EVHDDTDISI LLEPSEPELA THVKLFWSNG ERVTRVRNRD
     IITDSGDYRR GGSLAEKKRL GEGVYTLVCS TFAPDQLGRF TLWISSALPC VVKPLAPEAA
     GRRAVISDIG ILTPGKDRML ASLETKRLTR IKLIGRSRLS TIGNRAVGPS PMLMTVELGQ
     GPYKEILATS EDGNHSDAIS GVRIEDFDLH PGLADQGGAW IVIERIGGPG GQVEDHFEVE
     ALAEERVDIG EWIVEDA
//

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