(data stored in ACNUC7421 zone)

SWISSPROT: A2Q816_ASPNC

ID   A2Q816_ASPNC            Unreviewed;       887 AA.
AC   A2Q816;
DT   06-MAR-2007, integrated into UniProtKB/TrEMBL.
DT   06-MAR-2007, sequence version 1.
DT   11-DEC-2019, entry version 98.
DE   RecName: Full=DNA helicase {ECO:0000256|SAAS:SAAS00536514};
DE            EC=3.6.4.12 {ECO:0000256|SAAS:SAAS00536514};
GN   ORFNames=An01g02720 {ECO:0000313|EMBL:CAK43639.1};
OS   Aspergillus niger (strain CBS 513.88 / FGSC A1513).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus.
OX   NCBI_TaxID=425011 {ECO:0000313|Proteomes:UP000006706};
RN   [1] {ECO:0000313|EMBL:CAK43639.1, ECO:0000313|Proteomes:UP000006706}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CBS 513.88 / FGSC A1513 {ECO:0000313|Proteomes:UP000006706};
RX   PubMed=17259976; DOI=10.1038/nbt1282;
RA   Pel H.J., de Winde J.H., Archer D.B., Dyer P.S., Hofmann G., Schaap P.J.,
RA   Turner G., de Vries R.P., Albang R., Albermann K., Andersen M.R.,
RA   Bendtsen J.D., Benen J.A., van den Berg M., Breestraat S., Caddick M.X.,
RA   Contreras R., Cornell M., Coutinho P.M., Danchin E.G., Debets A.J.,
RA   Dekker P., van Dijck P.W., van Dijk A., Dijkhuizen L., Driessen A.J.,
RA   d'Enfert C., Geysens S., Goosen C., Groot G.S., de Groot P.W.,
RA   Guillemette T., Henrissat B., Herweijer M., van den Hombergh J.P.,
RA   van den Hondel C.A., van der Heijden R.T., van der Kaaij R.M., Klis F.M.,
RA   Kools H.J., Kubicek C.P., van Kuyk P.A., Lauber J., Lu X.,
RA   van der Maarel M.J., Meulenberg R., Menke H., Mortimer M.A., Nielsen J.,
RA   Oliver S.G., Olsthoorn M., Pal K., van Peij N.N., Ram A.F., Rinas U.,
RA   Roubos J.A., Sagt C.M., Schmoll M., Sun J., Ussery D., Varga J.,
RA   Vervecken W., van de Vondervoort P.J., Wedler H., Wosten H.A., Zeng A.P.,
RA   van Ooyen A.J., Visser J., Stam H.;
RT   "Genome sequencing and analysis of the versatile cell factory Aspergillus
RT   niger CBS 513.88.";
RL   Nat. Biotechnol. 25:221-231(2007).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC         ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.12;
CC         Evidence={ECO:0000256|SAAS:SAAS01116611};
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|SAAS:SAAS00536536}.
CC   -!- SIMILARITY: Belongs to the MCM family. {ECO:0000256|RuleBase:RU004070,
CC       ECO:0000256|SAAS:SAAS01112249}.
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DR   EMBL; AM269955; CAK43639.1; -; Genomic_DNA.
DR   RefSeq; XP_001388707.1; XM_001388670.1.
DR   PaxDb; A2Q816; -.
DR   EnsemblFungi; CAK43639; CAK43639; An01g02720.
DR   GeneID; 4978167; -.
DR   KEGG; ang:ANI_1_342014; -.
DR   HOGENOM; HOG000224126; -.
DR   KO; K02541; -.
DR   Proteomes; UP000006706; Chromosome 2R.
DR   GO; GO:0042555; C:MCM complex; IEA:InterPro.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003678; F:DNA helicase activity; IEA:UniProtKB-EC.
DR   GO; GO:0006270; P:DNA replication initiation; IEA:InterPro.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR031327; MCM.
DR   InterPro; IPR008046; Mcm3.
DR   InterPro; IPR018525; MCM_CS.
DR   InterPro; IPR001208; MCM_dom.
DR   InterPro; IPR041562; MCM_lid.
DR   InterPro; IPR027925; MCM_N.
DR   InterPro; IPR033762; MCM_OB.
DR   InterPro; IPR012340; NA-bd_OB-fold.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR11630; PTHR11630; 1.
DR   Pfam; PF00493; MCM; 1.
DR   Pfam; PF17855; MCM_lid; 1.
DR   Pfam; PF14551; MCM_N; 1.
DR   Pfam; PF17207; MCM_OB; 1.
DR   PRINTS; PR01657; MCMFAMILY.
DR   PRINTS; PR01659; MCMPROTEIN3.
DR   SMART; SM00382; AAA; 1.
DR   SMART; SM00350; MCM; 1.
DR   SUPFAM; SSF50249; SSF50249; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   PROSITE; PS00847; MCM_1; 1.
DR   PROSITE; PS50051; MCM_2; 1.
PE   3: Inferred from homology;
DR   PRODOM; A2Q816.
DR   SWISS-2DPAGE; A2Q816.
KW   ATP-binding {ECO:0000256|RuleBase:RU004070, ECO:0000256|SAAS:SAAS01112253};
KW   DNA replication {ECO:0000256|SAAS:SAAS00619122};
KW   DNA-binding {ECO:0000256|RuleBase:RU004070, ECO:0000256|SAAS:SAAS01112237};
KW   Helicase {ECO:0000256|SAAS:SAAS00536375};
KW   Hydrolase {ECO:0000256|SAAS:SAAS00536681};
KW   Nucleotide-binding {ECO:0000256|RuleBase:RU004070,
KW   ECO:0000256|SAAS:SAAS01112230}; Nucleus {ECO:0000256|SAAS:SAAS00536508}.
FT   DOMAIN          300..506
FT                   /note="MCM"
FT                   /evidence="ECO:0000259|PROSITE:PS50051"
FT   REGION          672..806
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        697..711
FT                   /note="Polar"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        752..806
FT                   /note="Polar"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   887 AA;  98097 MW;  CF1DC1C208CC489D CRC64;
     MEGQFDDAAQ DRVRAAVEFL DPSDARARSY RADILLMLNR GLRRLIVSID EIRAHNREMA
     DGLLTSPYEY SDAFEKALKE IIKTLPNRPS RETGDDVNYH CGFVGAFGEY SCNPRTLGSS
     HLNRMISLEG IVTKCSLVRP KIIQSVHWSE RGQKFLTRKY MDATMTASGA TSMSIYPQED
     EEKNPLVTEY GFSTYMDHQT ISIQEMPERA PAGQLPRSVD VIVDDDLVDR AKPGDRIQLV
     GVYRSLGNRN ASSTSATFRT LVLANNIIQL SSKSGGGIAQ ATITDTDIRN INKVSKKKGV
     FELLSHSLAP SIYGHDYIKK AILLMLLGGM EKNLDNGTHL RGDINILMVG DPSTAKSQLL
     RFVLNTAPLA IATTGRGSSG VGLTAAVTSD KETGERRLEA GAMVLGDRGV VCIDEFDKMS
     DVDRVAIHEV MEQQTVTIAK AGIHTSLNAR CSVLAAANPI YGQYDPHKDP HKNIALPDSL
     LSRFDLLFVV TDDIEDSRDR MVSEHVLRMH RYRQPGTEEG APVREQLHQT LGVGLEDTQD
     SNQPTDVYEK FNVMLHAGMA HMSRSKSKNI EILSIPFIKK YIQYAKSRVK PVLTKGAADH
     IVATYSALRN DELSGNQRRT SPITARTLET LIRLSTAHAK SRLSNRVEER DAKIAESILR
     FAMFKEIVED ERRKRRKVAS FDEDSESSDS DSDDDDNTPA QTSSATPRST RRGGLRSRGA
     NARSTTNEDT EMDADGDAVS EDGDGLYNAS PRGQRLRSSQ TSRTQTQTQS QSRMSVASSR
     PASQLVESQT DNSQSQNTTV SSEPIQPARL TVFRQALGPL MGTRLFTHGD TADVESLIGA
     VNTALRSTPS LGESHVFQRG EAIQALRAMN ERNELMYLEE DETVYRI
//

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