(data stored in ACNUC1104 zone)

SWISSPROT: A4F5P2_SACEN

ID   A4F5P2_SACEN            Unreviewed;       480 AA.
AC   A4F5P2;
DT   17-APR-2007, integrated into UniProtKB/TrEMBL.
DT   17-APR-2007, sequence version 1.
DT   10-APR-2019, entry version 59.
DE   RecName: Full=Dioxygenase {ECO:0000256|RuleBase:RU364048};
DE            EC=1.13.11.- {ECO:0000256|RuleBase:RU364048};
GN   OrderedLocusNames=SACE_0013 {ECO:0000313|EMBL:CAL99366.1};
GN   ORFNames=A8924_0396 {ECO:0000313|EMBL:PFG93166.1};
OS   Saccharopolyspora erythraea (strain ATCC 11635 / DSM 40517 / JCM 4748
OS   / NBRC 13426 / NCIMB 8594 / NRRL 2338).
OC   Bacteria; Actinobacteria; Pseudonocardiales; Pseudonocardiaceae;
OC   Saccharopolyspora.
OX   NCBI_TaxID=405948 {ECO:0000313|EMBL:CAL99366.1, ECO:0000313|Proteomes:UP000006728};
RN   [1] {ECO:0000313|EMBL:CAL99366.1, ECO:0000313|Proteomes:UP000006728}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 11635 / DSM 40517 / JCM 4748 / NBRC 13426 / NCIMB 8594 /
RC   NRRL 2338 {ECO:0000313|Proteomes:UP000006728}, and NRRL 2338
RC   {ECO:0000313|EMBL:CAL99366.1};
RX   PubMed=17369815; DOI=10.1038/nbt1297;
RA   Oliynyk M., Samborskyy M., Lester J.B., Mironenko T., Scott N.,
RA   Dickens S., Haydock S.F., Leadlay P.F.;
RT   "Complete genome sequence of the erythromycin-producing bacterium
RT   Saccharopolyspora erythraea NRRL23338.";
RL   Nat. Biotechnol. 25:447-453(2007).
RN   [2] {ECO:0000313|EMBL:PFG93166.1, ECO:0000313|Proteomes:UP000225825}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 40517 {ECO:0000313|EMBL:PFG93166.1,
RC   ECO:0000313|Proteomes:UP000225825};
RA   Klenk H.-P.;
RT   "Sequencing the genomes of 1000 actinobacteria strains.";
RL   Submitted (SEP-2017) to the EMBL/GenBank/DDBJ databases.
CC   -!- COFACTOR:
CC       Name=Fe(2+); Xref=ChEBI:CHEBI:29033;
CC         Evidence={ECO:0000256|RuleBase:RU364048};
CC       Note=Binds 1 Fe(2+) ion per subunit.
CC       {ECO:0000256|RuleBase:RU364048};
CC   -!- SIMILARITY: Belongs to the carotenoid oxygenase family.
CC       {ECO:0000256|RuleBase:RU364048}.
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DR   EMBL; AM420293; CAL99366.1; -; Genomic_DNA.
DR   EMBL; PDBV01000001; PFG93166.1; -; Genomic_DNA.
DR   RefSeq; WP_009945681.1; NZ_PDBV01000001.1.
DR   STRING; 405948.SACE_0013; -.
DR   EnsemblBacteria; CAL99366; CAL99366; SACE_0013.
DR   KEGG; sen:SACE_0013; -.
DR   eggNOG; ENOG4105ZTI; Bacteria.
DR   eggNOG; COG3670; LUCA.
DR   HOGENOM; HOG000232156; -.
DR   OMA; ITEFGTF; -.
DR   OrthoDB; 389495at2; -.
DR   BioCyc; SERY405948:SACE_RS00060-MONOMER; -.
DR   Proteomes; UP000006728; Chromosome.
DR   Proteomes; UP000225825; Unassembled WGS sequence.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0016702; F:oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen; IEA:InterPro.
DR   InterPro; IPR004294; Carotenoid_Oase.
DR   PANTHER; PTHR10543; PTHR10543; 1.
DR   Pfam; PF03055; RPE65; 1.
PE   3: Inferred from homology;
DR   PRODOM; A4F5P2.
DR   SWISS-2DPAGE; A4F5P2.
KW   Complete proteome {ECO:0000313|Proteomes:UP000006728,
KW   ECO:0000313|Proteomes:UP000225825};
KW   Dioxygenase {ECO:0000256|RuleBase:RU364048,
KW   ECO:0000313|EMBL:CAL99366.1}; Iron {ECO:0000256|RuleBase:RU364048};
KW   Metal-binding {ECO:0000256|RuleBase:RU364048};
KW   Oxidoreductase {ECO:0000256|RuleBase:RU364048};
KW   Reference proteome {ECO:0000313|Proteomes:UP000006728}.
SQ   SEQUENCE   480 AA;  53507 MW;  F84AEC92CDC38943 CRC64;
     MSTRTHSDDT PATGFARGFA SLESEVEVAE LPVTGELPEW LSGELLRNGP AKFEAGRRRF
     RHWFDGQAML HRFAIADGRV AYRNRFLDSP ALRSARDGRI RYAEFATDPC RSLFARLFTR
     FRRSEPSANA CVNVVPNGDD TYAALTEIPM AVDFDPHTLE TIGISGYDDS IGGNVTTAHP
     HQAPRTGDLV NYVLRFSRQS EYRIYRQRPD GRTRELLASV PTDQPGYLHS FAITEDHVVL
     VEFPFVVNPL AFLLSGKPFI ENYRWRPELG TRFIVIGLDD GSVRSVRTEE AFFAFHHINS
     YVDGGELVVD VCAYPDSGVV DSFYLDRLRS GARMPVPAPM RYRVDLDAGT ARSHRLAEEP
     LELPGISYGH RNGRPYRCAY GVGMRGHDGR DFLDQLVKID VEDGRSSTWY EGGCYPGEPV
     FVPAPEAEAE DDGAVLSVVL DSAAGRSFML ALDGRSFTEI ARAEVPHAIP FGFHGQFSSR
//

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