(data stored in ACNUC1104 zone)

SWISSPROT: A4F5P3_SACEN

ID   A4F5P3_SACEN            Unreviewed;      1030 AA.
AC   A4F5P3;
DT   17-APR-2007, integrated into UniProtKB/TrEMBL.
DT   17-APR-2007, sequence version 1.
DT   08-MAY-2019, entry version 60.
DE   SubName: Full=Conserved large membrane protein {ECO:0000313|EMBL:CAL99367.1};
DE   SubName: Full=RND superfamily putative drug exporter {ECO:0000313|EMBL:PFG93167.1};
GN   Name=mmpL10 {ECO:0000313|EMBL:CAL99367.1};
GN   OrderedLocusNames=SACE_0014 {ECO:0000313|EMBL:CAL99367.1};
GN   ORFNames=A8924_0397 {ECO:0000313|EMBL:PFG93167.1};
OS   Saccharopolyspora erythraea (strain ATCC 11635 / DSM 40517 / JCM 4748
OS   / NBRC 13426 / NCIMB 8594 / NRRL 2338).
OC   Bacteria; Actinobacteria; Pseudonocardiales; Pseudonocardiaceae;
OC   Saccharopolyspora.
OX   NCBI_TaxID=405948 {ECO:0000313|EMBL:CAL99367.1, ECO:0000313|Proteomes:UP000006728};
RN   [1] {ECO:0000313|EMBL:CAL99367.1, ECO:0000313|Proteomes:UP000006728}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 11635 / DSM 40517 / JCM 4748 / NBRC 13426 / NCIMB 8594 /
RC   NRRL 2338 {ECO:0000313|Proteomes:UP000006728}, and NRRL 2338
RC   {ECO:0000313|EMBL:CAL99367.1};
RX   PubMed=17369815; DOI=10.1038/nbt1297;
RA   Oliynyk M., Samborskyy M., Lester J.B., Mironenko T., Scott N.,
RA   Dickens S., Haydock S.F., Leadlay P.F.;
RT   "Complete genome sequence of the erythromycin-producing bacterium
RT   Saccharopolyspora erythraea NRRL23338.";
RL   Nat. Biotechnol. 25:447-453(2007).
RN   [2] {ECO:0000313|EMBL:PFG93167.1, ECO:0000313|Proteomes:UP000225825}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 40517 {ECO:0000313|EMBL:PFG93167.1,
RC   ECO:0000313|Proteomes:UP000225825};
RA   Klenk H.-P.;
RT   "Sequencing the genomes of 1000 actinobacteria strains.";
RL   Submitted (SEP-2017) to the EMBL/GenBank/DDBJ databases.
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DR   EMBL; AM420293; CAL99367.1; -; Genomic_DNA.
DR   EMBL; PDBV01000001; PFG93167.1; -; Genomic_DNA.
DR   RefSeq; WP_011872913.1; NZ_PDBV01000001.1.
DR   STRING; 405948.SACE_0014; -.
DR   EnsemblBacteria; CAL99367; CAL99367; SACE_0014.
DR   KEGG; sen:SACE_0014; -.
DR   eggNOG; ENOG4105EYF; Bacteria.
DR   eggNOG; COG2409; LUCA.
DR   HOGENOM; HOG000043539; -.
DR   KO; K06994; -.
DR   OMA; LFWPSKR; -.
DR   OrthoDB; 149255at2; -.
DR   BioCyc; SERY405948:SACE_RS00065-MONOMER; -.
DR   Proteomes; UP000006728; Chromosome.
DR   Proteomes; UP000225825; Unassembled WGS sequence.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   Gene3D; 3.30.2090.10; -; 1.
DR   InterPro; IPR027463; AcrB_DN_DC_subdom.
DR   InterPro; IPR004869; MMPL_dom.
DR   InterPro; IPR023908; xxxLxxG_rpt.
DR   Pfam; PF03176; MMPL; 2.
DR   TIGRFAMs; TIGR03057; xxxLxxG_by_4; 1.
PE   4: Predicted;
DR   PRODOM; A4F5P3.
DR   SWISS-2DPAGE; A4F5P3.
KW   Complete proteome {ECO:0000313|Proteomes:UP000006728,
KW   ECO:0000313|Proteomes:UP000225825};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000006728};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM     26     43       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    196    215       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    222    246       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    252    276       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    297    318       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    330    353       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    383    401       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    858    877       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    884    908       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    920    940       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    952    978       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    984   1015       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN       58    382       MMPL. {ECO:0000259|Pfam:PF03176}.
FT   DOMAIN      730   1023       MMPL. {ECO:0000259|Pfam:PF03176}.
SQ   SEQUENCE   1030 AA;  106341 MW;  3A1F2BA069469DB9 CRC64;
     MNATGSDERD GGPLARLSRF VVRRRGAVVC AWVAFAALLN VLVPQLEAVI GQSRVPFVPD
     SAPSVRALPE MDRRFGGEGA NSLVFVVLAD ESGLSEEDHR YYAELVGRME RDDSRIASVQ
     DAVSQPELAD ALVSRDGKAI YIPVGLRGEN GSPETTAQIK HIRETAQQGR PDSLAVHVTG
     PMATIADMQD EIERSMLVIT AVTVGLITAI LLVIYRSVVT ALVALALIGL SLGTARAVTA
     VCGLQFFDVS TFTASLLTAV VLGAGTDYGV FLLSRFHERI RAGDDPEQAV ITANRRVAAV
     IAASAGTVIA ACSGMALAEV SIFRTTGPAI AVSLAVTLAA GLTLTPALLA IAATRGWAMP
     RRSPENGRWT AIAERVVARP ARVLAAGLVV LLLLAAFYPA ARLSYDERAV QPAATDSNLG
     YGALGKHFPA GEILPEYLLV NSDHDMRNPQ DLAALETAAA NVAKVDGVRA VRGVTRPTGE
     PIAEANVGNQ VGVVGDRLGA AEEQLGGGQQ GIGGLADGAG RLADGTGRLA GGAAELAAGS
     GRLAAGARSA VDGADQLLNG LNTAHGGLGT AGDGADDAGS AATTLAEGAR QLATGLDLAR
     DQTSLAVDGL GLAYHALQAD AVCSLDPICA QARKGIGDIY VSERDQLLPG LEQAAAAAHK
     IADGNGDLAS GMDDLRGGIA TARDGIARLA EGQRTMRDQL GALADGAGQA ANGAQQLSDN
     AGLAADGAGR LRDGTANATV SVKELERGLA QAADFLRTVR AESHHPGVGG FYLPPNALSD
     PRMAMASGMF LSGDGRTARL VVLHSGDPLD RAAMDRTGEI VRTAEHALRG TSLDGSGVHN
     TGSASVNRDL ARMSDADFSV FALVALLSVL VILMLLLRSV VAPIYLLVSV ILSYAAAMGI
     AVLFWQFLLG GELDWSVQPI AFVILVAVGA DYNMLLMSRI REESDDGSRA GIARAVATTG
     GVITSAGIIF AASMFALMSG TVDILAQLGF TIGVGLLLDT FVVRTLVIPA IAVLLRKWNW
     WPSKNAGESG
//

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