(data stored in ACNUC1104 zone)

SWISSPROT: A4F5S3_SACEN

ID   A4F5S3_SACEN            Unreviewed;       653 AA.
AC   A4F5S3;
DT   17-APR-2007, integrated into UniProtKB/TrEMBL.
DT   17-APR-2007, sequence version 1.
DT   08-MAY-2019, entry version 80.
DE   SubName: Full=Serine/threonine-protein kinase {ECO:0000313|EMBL:CAL99397.1, ECO:0000313|EMBL:PFG93197.1};
DE            EC=2.7.11.1 {ECO:0000313|EMBL:CAL99397.1};
GN   Name=pknB {ECO:0000313|EMBL:CAL99397.1};
GN   OrderedLocusNames=SACE_0044 {ECO:0000313|EMBL:CAL99397.1};
GN   ORFNames=A8924_0428 {ECO:0000313|EMBL:PFG93197.1};
OS   Saccharopolyspora erythraea (strain ATCC 11635 / DSM 40517 / JCM 4748
OS   / NBRC 13426 / NCIMB 8594 / NRRL 2338).
OC   Bacteria; Actinobacteria; Pseudonocardiales; Pseudonocardiaceae;
OC   Saccharopolyspora.
OX   NCBI_TaxID=405948 {ECO:0000313|EMBL:CAL99397.1, ECO:0000313|Proteomes:UP000006728};
RN   [1] {ECO:0000313|EMBL:CAL99397.1, ECO:0000313|Proteomes:UP000006728}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 11635 / DSM 40517 / JCM 4748 / NBRC 13426 / NCIMB 8594 /
RC   NRRL 2338 {ECO:0000313|Proteomes:UP000006728}, and NRRL 2338
RC   {ECO:0000313|EMBL:CAL99397.1};
RX   PubMed=17369815; DOI=10.1038/nbt1297;
RA   Oliynyk M., Samborskyy M., Lester J.B., Mironenko T., Scott N.,
RA   Dickens S., Haydock S.F., Leadlay P.F.;
RT   "Complete genome sequence of the erythromycin-producing bacterium
RT   Saccharopolyspora erythraea NRRL23338.";
RL   Nat. Biotechnol. 25:447-453(2007).
RN   [2] {ECO:0000313|EMBL:PFG93197.1, ECO:0000313|Proteomes:UP000225825}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 40517 {ECO:0000313|EMBL:PFG93197.1,
RC   ECO:0000313|Proteomes:UP000225825};
RA   Klenk H.-P.;
RT   "Sequencing the genomes of 1000 actinobacteria strains.";
RL   Submitted (SEP-2017) to the EMBL/GenBank/DDBJ databases.
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DR   EMBL; AM420293; CAL99397.1; -; Genomic_DNA.
DR   EMBL; PDBV01000001; PFG93197.1; -; Genomic_DNA.
DR   RefSeq; WP_009950432.1; NZ_PDBV01000001.1.
DR   STRING; 405948.SACE_0044; -.
DR   EnsemblBacteria; CAL99397; CAL99397; SACE_0044.
DR   KEGG; sen:SACE_0044; -.
DR   eggNOG; ENOG4105D9P; Bacteria.
DR   eggNOG; COG0515; LUCA.
DR   HOGENOM; HOG000037185; -.
DR   KO; K12132; -.
DR   OMA; MTQSQGV; -.
DR   OrthoDB; 1377603at2; -.
DR   BioCyc; SERY405948:SACE_RS00205-MONOMER; -.
DR   Proteomes; UP000006728; Chromosome.
DR   Proteomes; UP000225825; Unassembled WGS sequence.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
DR   InterPro; IPR011009; Kinase-like_dom_sf.
DR   InterPro; IPR005543; PASTA_dom.
DR   InterPro; IPR000719; Prot_kinase_dom.
DR   InterPro; IPR017441; Protein_kinase_ATP_BS.
DR   InterPro; IPR008271; Ser/Thr_kinase_AS.
DR   Pfam; PF03793; PASTA; 4.
DR   Pfam; PF00069; Pkinase; 1.
DR   SMART; SM00740; PASTA; 4.
DR   SMART; SM00220; S_TKc; 1.
DR   SUPFAM; SSF56112; SSF56112; 1.
DR   PROSITE; PS51178; PASTA; 4.
DR   PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
DR   PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR   PROSITE; PS00108; PROTEIN_KINASE_ST; 1.
PE   4: Predicted;
DR   PRODOM; A4F5S3.
DR   SWISS-2DPAGE; A4F5S3.
KW   Complete proteome {ECO:0000313|Proteomes:UP000006728,
KW   ECO:0000313|Proteomes:UP000225825};
KW   Kinase {ECO:0000313|EMBL:CAL99397.1};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000006728};
KW   Serine/threonine-protein kinase {ECO:0000313|EMBL:CAL99397.1};
KW   Transferase {ECO:0000313|EMBL:CAL99397.1};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    335    355       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN       11    274       Protein kinase. {ECO:0000259|PROSITE:
FT                                PS50011}.
FT   DOMAIN      364    432       PASTA. {ECO:0000259|PROSITE:PS51178}.
FT   DOMAIN      433    500       PASTA. {ECO:0000259|PROSITE:PS51178}.
FT   DOMAIN      501    566       PASTA. {ECO:0000259|PROSITE:PS51178}.
FT   DOMAIN      567    635       PASTA. {ECO:0000259|PROSITE:PS51178}.
SQ   SEQUENCE   653 AA;  71131 MW;  9A8A1A39DBD49FEB CRC64;
     MSSPRLLSNR YEIGDTLGYG GMSEVHRGRD IRLGRDVAVK VLRADLARDP TFQLRFRREA
     QNAAALNHPA IVAVYDTGET DSENGPLPYI VMEYVDGRTL RDIVKSEGPL APRRAMEVMA
     DASAALDFSH RHHIIHRDVK PANIMITRSG AVKVMDFGIA RALTDGQAAV TQTAAVIGTA
     QYLSPEQARG ESVDARSDVY ASGCVLFELL TGEPPFTGDS PVAVAYQHVR EDPRKPSDVN
     QQVPASLDAV VLKALSKNPA NRYQSAAEMR ADLVRVLSGQ RPKAPMIMSE EERTSMIAPA
     PATEVMAPGG RHRSVEPAVE DDLDAEQQRK RRKNWLIALV TLICVAVFAL VAWVANALLS
     GPSGDDKIAV PQLEGMTKSQ ALSELTAGNW LWQEQIPCPS SREDVGRVIN QTPDPGVPID
     KKQDRIRVCF GTGPEQVQIP DLRGMSMDQA SAKLSEVGLM LGYNPKTREV DNDSQVDKIL
     EWDPEGTVAK GTTINVVLGK KAEQRAVPDV RNMPYETAER MLSYAGFQVQ RSDRDSSEPA
     GIVVDQTPAA DTKLKPGSKV TVYVSNGQQI SMPPLTGLSP TDAKRQLQQL GWNGQLVEQK
     ESTSDSKLDG KVMRSSPSGG DKISKNQTIT IYVGEYDSSP TTQPDDGFFP PFP
//

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