(data stored in ACNUC1104 zone)

SWISSPROT: A4F5Y1_SACEN

ID   A4F5Y1_SACEN            Unreviewed;       484 AA.
AC   A4F5Y1;
DT   17-APR-2007, integrated into UniProtKB/TrEMBL.
DT   17-APR-2007, sequence version 1.
DT   08-MAY-2019, entry version 84.
DE   SubName: Full=Signal transduction histidine kinase {ECO:0000313|EMBL:PFG93254.1};
DE   SubName: Full=Two component sensor kinase {ECO:0000313|EMBL:CAL99455.1};
GN   OrderedLocusNames=SACE_0102 {ECO:0000313|EMBL:CAL99455.1};
GN   ORFNames=A8924_0487 {ECO:0000313|EMBL:PFG93254.1};
OS   Saccharopolyspora erythraea (strain ATCC 11635 / DSM 40517 / JCM 4748
OS   / NBRC 13426 / NCIMB 8594 / NRRL 2338).
OC   Bacteria; Actinobacteria; Pseudonocardiales; Pseudonocardiaceae;
OC   Saccharopolyspora.
OX   NCBI_TaxID=405948 {ECO:0000313|EMBL:CAL99455.1, ECO:0000313|Proteomes:UP000006728};
RN   [1] {ECO:0000313|EMBL:CAL99455.1, ECO:0000313|Proteomes:UP000006728}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 11635 / DSM 40517 / JCM 4748 / NBRC 13426 / NCIMB 8594 /
RC   NRRL 2338 {ECO:0000313|Proteomes:UP000006728}, and NRRL 2338
RC   {ECO:0000313|EMBL:CAL99455.1};
RX   PubMed=17369815; DOI=10.1038/nbt1297;
RA   Oliynyk M., Samborskyy M., Lester J.B., Mironenko T., Scott N.,
RA   Dickens S., Haydock S.F., Leadlay P.F.;
RT   "Complete genome sequence of the erythromycin-producing bacterium
RT   Saccharopolyspora erythraea NRRL23338.";
RL   Nat. Biotechnol. 25:447-453(2007).
RN   [2] {ECO:0000313|EMBL:PFG93254.1, ECO:0000313|Proteomes:UP000225825}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 40517 {ECO:0000313|EMBL:PFG93254.1,
RC   ECO:0000313|Proteomes:UP000225825};
RA   Klenk H.-P.;
RT   "Sequencing the genomes of 1000 actinobacteria strains.";
RL   Submitted (SEP-2017) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + protein L-histidine = ADP + protein N-phospho-L-
CC         histidine.; EC=2.7.13.3;
CC         Evidence={ECO:0000256|SAAS:SAAS01126420};
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DR   EMBL; AM420293; CAL99455.1; -; Genomic_DNA.
DR   EMBL; PDBV01000001; PFG93254.1; -; Genomic_DNA.
DR   RefSeq; WP_009950871.1; NZ_PDBV01000001.1.
DR   STRING; 405948.SACE_0102; -.
DR   EnsemblBacteria; CAL99455; CAL99455; SACE_0102.
DR   KEGG; sen:SACE_0102; -.
DR   eggNOG; ENOG4105GR3; Bacteria.
DR   eggNOG; COG0642; LUCA.
DR   HOGENOM; HOG000223177; -.
DR   OMA; FNEMMDR; -.
DR   OrthoDB; 692375at2; -.
DR   BioCyc; SERY405948:SACE_RS00480-MONOMER; -.
DR   Proteomes; UP000006728; Chromosome.
DR   Proteomes; UP000225825; Unassembled WGS sequence.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0000155; F:phosphorelay sensor kinase activity; IEA:InterPro.
DR   CDD; cd06225; HAMP; 1.
DR   CDD; cd00075; HATPase_c; 1.
DR   CDD; cd00082; HisKA; 1.
DR   Gene3D; 3.30.565.10; -; 1.
DR   InterPro; IPR003660; HAMP_dom.
DR   InterPro; IPR003594; HATPase_C.
DR   InterPro; IPR036890; HATPase_C_sf.
DR   InterPro; IPR005467; His_kinase_dom.
DR   InterPro; IPR003661; HisK_dim/P.
DR   InterPro; IPR036097; HisK_dim/P_sf.
DR   InterPro; IPR004358; Sig_transdc_His_kin-like_C.
DR   Pfam; PF00672; HAMP; 1.
DR   Pfam; PF02518; HATPase_c; 1.
DR   Pfam; PF00512; HisKA; 1.
DR   PRINTS; PR00344; BCTRLSENSOR.
DR   SMART; SM00304; HAMP; 1.
DR   SMART; SM00387; HATPase_c; 1.
DR   SMART; SM00388; HisKA; 1.
DR   SUPFAM; SSF47384; SSF47384; 1.
DR   SUPFAM; SSF55874; SSF55874; 1.
DR   PROSITE; PS50885; HAMP; 1.
DR   PROSITE; PS50109; HIS_KIN; 1.
PE   4: Predicted;
DR   PRODOM; A4F5Y1.
DR   SWISS-2DPAGE; A4F5Y1.
KW   ATP-binding {ECO:0000256|SAAS:SAAS00925949};
KW   Complete proteome {ECO:0000313|Proteomes:UP000006728,
KW   ECO:0000313|Proteomes:UP000225825};
KW   Kinase {ECO:0000256|SAAS:SAAS01003914, ECO:0000313|EMBL:CAL99455.1};
KW   Membrane {ECO:0000256|SAAS:SAAS00925724, ECO:0000256|SAM:Phobius};
KW   Nucleotide-binding {ECO:0000256|SAAS:SAAS00925310};
KW   Reference proteome {ECO:0000313|Proteomes:UP000006728};
KW   Transferase {ECO:0000256|SAAS:SAAS01003669};
KW   Transmembrane {ECO:0000256|SAAS:SAAS00926038,
KW   ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAAS:SAAS00926160,
KW   ECO:0000256|SAM:Phobius};
KW   Two-component regulatory system {ECO:0000256|SAAS:SAAS00924981}.
FT   TRANSMEM     22     41       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN      208    260       HAMP. {ECO:0000259|PROSITE:PS50885}.
FT   DOMAIN      268    474       Histidine kinase. {ECO:0000259|PROSITE:
FT                                PS50109}.
SQ   SEQUENCE   484 AA;  52776 MW;  4C5EF6969A7D2A79 CRC64;
     MTTEPRTAQR RHGTRIPARA QIMGWMLLVL VVVLLSVILI VRQFLHNDVN NQVTRSMEQE
     AREFSQFAEK GRDPVTRQLF TDPQSLFHSH LSRQYPDTAE ALIGVWRTPA GLEPITQAQD
     GLKPVASDPA VLGPIVSSPA NHGRVDTPAG PMRWVKVHAV SNGVDAWFVT EHFTAAETAE
     ADRTVQTLLL VSAFGVLLAA ISSWVVAAEI LAPVRTVRQA AAEISEHDLT RRIPVEGRDD
     IAALADQFNA MLDRLEDAFR TQRRFVDDAS HELRTPITIV RGNLELLGDD PAEREEVVRL
     CTDELDRMTR IVEDLLMLAK ADRPDFVTPA PVSLAELTSD IEAKARSIAD RRWVLEGIGE
     GEVVVDEQRV TQAMVQLAQN AVQHTEPGST IRIGSALSLG RISLWVTDEG PGVDPAEVEK
     IFERFSHGSG PGRGGAGLGL AIVRAIAEAH HGRVRVLSAP GEGATFGLEL PATPGTRTAE
     ESDS
//

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