(data stored in ACNUC1104 zone)

SWISSPROT: A4F6E1_SACEN

ID   A4F6E1_SACEN            Unreviewed;       504 AA.
AC   A4F6E1;
DT   17-APR-2007, integrated into UniProtKB/TrEMBL.
DT   17-APR-2007, sequence version 1.
DT   08-MAY-2019, entry version 87.
DE   SubName: Full=Two component system histidine kinase {ECO:0000313|EMBL:CAL99615.1};
GN   OrderedLocusNames=SACE_0265 {ECO:0000313|EMBL:CAL99615.1};
OS   Saccharopolyspora erythraea (strain ATCC 11635 / DSM 40517 / JCM 4748
OS   / NBRC 13426 / NCIMB 8594 / NRRL 2338).
OC   Bacteria; Actinobacteria; Pseudonocardiales; Pseudonocardiaceae;
OC   Saccharopolyspora.
OX   NCBI_TaxID=405948 {ECO:0000313|EMBL:CAL99615.1, ECO:0000313|Proteomes:UP000006728};
RN   [1] {ECO:0000313|EMBL:CAL99615.1, ECO:0000313|Proteomes:UP000006728}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 11635 / DSM 40517 / JCM 4748 / NBRC 13426 / NCIMB 8594 /
RC   NRRL 2338 {ECO:0000313|Proteomes:UP000006728};
RX   PubMed=17369815; DOI=10.1038/nbt1297;
RA   Oliynyk M., Samborskyy M., Lester J.B., Mironenko T., Scott N.,
RA   Dickens S., Haydock S.F., Leadlay P.F.;
RT   "Complete genome sequence of the erythromycin-producing bacterium
RT   Saccharopolyspora erythraea NRRL23338.";
RL   Nat. Biotechnol. 25:447-453(2007).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + protein L-histidine = ADP + protein N-phospho-L-
CC         histidine.; EC=2.7.13.3;
CC         Evidence={ECO:0000256|SAAS:SAAS01126420};
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DR   EMBL; AM420293; CAL99615.1; -; Genomic_DNA.
DR   RefSeq; WP_011872996.1; NZ_PDBV01000001.1.
DR   STRING; 405948.SACE_0265; -.
DR   EnsemblBacteria; CAL99615; CAL99615; SACE_0265.
DR   KEGG; sen:SACE_0265; -.
DR   eggNOG; ENOG41065SU; Bacteria.
DR   eggNOG; COG0642; LUCA.
DR   HOGENOM; HOG000223177; -.
DR   KO; K07654; -.
DR   OMA; GLWIAST; -.
DR   OrthoDB; 1827824at2; -.
DR   BioCyc; SERY405948:SACE_RS01305-MONOMER; -.
DR   Proteomes; UP000006728; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0000155; F:phosphorelay sensor kinase activity; IEA:InterPro.
DR   CDD; cd06225; HAMP; 1.
DR   CDD; cd00075; HATPase_c; 1.
DR   CDD; cd00082; HisKA; 1.
DR   Gene3D; 3.30.565.10; -; 1.
DR   InterPro; IPR003660; HAMP_dom.
DR   InterPro; IPR003594; HATPase_C.
DR   InterPro; IPR036890; HATPase_C_sf.
DR   InterPro; IPR005467; His_kinase_dom.
DR   InterPro; IPR003661; HisK_dim/P.
DR   InterPro; IPR036097; HisK_dim/P_sf.
DR   InterPro; IPR004358; Sig_transdc_His_kin-like_C.
DR   Pfam; PF00672; HAMP; 1.
DR   Pfam; PF02518; HATPase_c; 1.
DR   Pfam; PF00512; HisKA; 1.
DR   PRINTS; PR00344; BCTRLSENSOR.
DR   SMART; SM00304; HAMP; 1.
DR   SMART; SM00387; HATPase_c; 1.
DR   SMART; SM00388; HisKA; 1.
DR   SUPFAM; SSF47384; SSF47384; 1.
DR   SUPFAM; SSF55874; SSF55874; 1.
DR   PROSITE; PS50885; HAMP; 1.
DR   PROSITE; PS50109; HIS_KIN; 1.
PE   4: Predicted;
DR   PRODOM; A4F6E1.
DR   SWISS-2DPAGE; A4F6E1.
KW   ATP-binding {ECO:0000256|SAAS:SAAS00925949};
KW   Complete proteome {ECO:0000313|Proteomes:UP000006728};
KW   Kinase {ECO:0000256|SAAS:SAAS01003914, ECO:0000313|EMBL:CAL99615.1};
KW   Membrane {ECO:0000256|SAAS:SAAS00925724, ECO:0000256|SAM:Phobius};
KW   Nucleotide-binding {ECO:0000256|SAAS:SAAS00925310};
KW   Reference proteome {ECO:0000313|Proteomes:UP000006728};
KW   Signal {ECO:0000256|SAM:SignalP};
KW   Transferase {ECO:0000256|SAAS:SAAS01003669};
KW   Transmembrane {ECO:0000256|SAAS:SAAS00926038,
KW   ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAAS:SAAS00926160,
KW   ECO:0000256|SAM:Phobius};
KW   Two-component regulatory system {ECO:0000256|SAAS:SAAS00924981}.
FT   SIGNAL        1     21       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        22    504       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5002668688.
FT   TRANSMEM    197    218       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN      218    270       HAMP. {ECO:0000259|PROSITE:PS50885}.
FT   DOMAIN      285    490       Histidine kinase. {ECO:0000259|PROSITE:
FT                                PS50109}.
SQ   SEQUENCE   504 AA;  53636 MW;  12B09443E66EB3AE CRC64;
     MRIVVALMVV TTTATVAMAF AAYRLQATGT TDRFNAAASA GFLSDLSQAQ ARYRTAAEPK
     DRIKTVADYM IGRKGLHWSV VDFMPSANGP APGPVWLLEG PDYYYGPQLR PEHVDASSLR
     FEGFPEPAFV ATTTPWVNRT AGLVARARTG GTTTETVPVE GGGQLLAFAS RVGPDLVLVE
     FYDMQPLHSE LSQLRNALAV VALGVSALGV VLALLAAASV QRPVRKVAAA AHRIGEGAFD
     TRLPVRGKDE IAELTSAFNT MAQRLGDSIE ELRVKDRQQQ RFVADVAHDL RTPTASLVAA
     ADSLEHPDPE SRSRAVALVS TQARRLARLV DDLLEISRFD SGAAELRPEG VDLRELVREA
     IELVTCDADV RLDATADTTL VGDPRRLHTI VCNLLANAVH HGAEPVTVAI DGTDPGQVVL
     RVADSGPGVP EELTRILFDR FVRGDRARSA TDGSGLGMAI AQQNALVHGG RITVHNDGGA
     VFTLTLPRGD RSATGSDAPG PSTA
//

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