(data stored in ACNUC1104 zone)

SWISSPROT: A4F6L7_SACEN

ID   A4F6L7_SACEN            Unreviewed;       448 AA.
AC   A4F6L7;
DT   17-APR-2007, integrated into UniProtKB/TrEMBL.
DT   17-APR-2007, sequence version 1.
DT   08-MAY-2019, entry version 73.
DE   SubName: Full=D-glucarate dehydratase {ECO:0000313|EMBL:PFG93494.1};
DE   SubName: Full=Mandelate racemase/muconate lactonizing enzyme {ECO:0000313|EMBL:CAL99691.1};
DE            EC=4.2.1.40 {ECO:0000313|EMBL:CAL99691.1};
GN   OrderedLocusNames=SACE_0342 {ECO:0000313|EMBL:CAL99691.1};
GN   ORFNames=A8924_0737 {ECO:0000313|EMBL:PFG93494.1};
OS   Saccharopolyspora erythraea (strain ATCC 11635 / DSM 40517 / JCM 4748
OS   / NBRC 13426 / NCIMB 8594 / NRRL 2338).
OC   Bacteria; Actinobacteria; Pseudonocardiales; Pseudonocardiaceae;
OC   Saccharopolyspora.
OX   NCBI_TaxID=405948 {ECO:0000313|EMBL:CAL99691.1, ECO:0000313|Proteomes:UP000006728};
RN   [1] {ECO:0000313|EMBL:CAL99691.1, ECO:0000313|Proteomes:UP000006728}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 11635 / DSM 40517 / JCM 4748 / NBRC 13426 / NCIMB 8594 /
RC   NRRL 2338 {ECO:0000313|Proteomes:UP000006728}, and NRRL 2338
RC   {ECO:0000313|EMBL:CAL99691.1};
RX   PubMed=17369815; DOI=10.1038/nbt1297;
RA   Oliynyk M., Samborskyy M., Lester J.B., Mironenko T., Scott N.,
RA   Dickens S., Haydock S.F., Leadlay P.F.;
RT   "Complete genome sequence of the erythromycin-producing bacterium
RT   Saccharopolyspora erythraea NRRL23338.";
RL   Nat. Biotechnol. 25:447-453(2007).
RN   [2] {ECO:0000313|EMBL:PFG93494.1, ECO:0000313|Proteomes:UP000225825}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 40517 {ECO:0000313|EMBL:PFG93494.1,
RC   ECO:0000313|Proteomes:UP000225825};
RA   Klenk H.-P.;
RT   "Sequencing the genomes of 1000 actinobacteria strains.";
RL   Submitted (SEP-2017) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the mandelate racemase/muconate lactonizing
CC       enzyme family. {ECO:0000256|SAAS:SAAS01080498}.
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DR   EMBL; AM420293; CAL99691.1; -; Genomic_DNA.
DR   EMBL; PDBV01000001; PFG93494.1; -; Genomic_DNA.
DR   RefSeq; WP_011873026.1; NZ_PDBV01000001.1.
DR   STRING; 405948.SACE_0342; -.
DR   EnsemblBacteria; CAL99691; CAL99691; SACE_0342.
DR   KEGG; sen:SACE_0342; -.
DR   HOGENOM; HOG000238021; -.
DR   KO; K01706; -.
DR   OMA; RVAQMCN; -.
DR   OrthoDB; 951991at2; -.
DR   BioCyc; SERY405948:SACE_RS01675-MONOMER; -.
DR   Proteomes; UP000006728; Chromosome.
DR   Proteomes; UP000225825; Unassembled WGS sequence.
DR   GO; GO:0008872; F:glucarate dehydratase activity; IEA:UniProtKB-EC.
DR   GO; GO:0000287; F:magnesium ion binding; IEA:InterPro.
DR   GO; GO:0019394; P:glucarate catabolic process; IEA:InterPro.
DR   CDD; cd03323; D-glucarate_dehydratase; 1.
DR   Gene3D; 3.20.20.120; -; 1.
DR   Gene3D; 3.30.390.10; -; 1.
DR   InterPro; IPR036849; Enolase-like_C_sf.
DR   InterPro; IPR029017; Enolase-like_N.
DR   InterPro; IPR029065; Enolase_C-like.
DR   InterPro; IPR017653; Glucarate_dehydratase.
DR   InterPro; IPR034598; GlucD-like.
DR   InterPro; IPR034593; Mandelate_racemase-like.
DR   InterPro; IPR013342; Mandelate_racemase_C.
DR   InterPro; IPR013341; Mandelate_racemase_N_dom.
DR   PANTHER; PTHR43287; PTHR43287; 1.
DR   Pfam; PF13378; MR_MLE_C; 1.
DR   Pfam; PF02746; MR_MLE_N; 1.
DR   SMART; SM00922; MR_MLE; 1.
DR   SUPFAM; SSF51604; SSF51604; 1.
DR   TIGRFAMs; TIGR03247; glucar-dehydr; 1.
PE   3: Inferred from homology;
DR   PRODOM; A4F6L7.
DR   SWISS-2DPAGE; A4F6L7.
KW   Complete proteome {ECO:0000313|Proteomes:UP000006728,
KW   ECO:0000313|Proteomes:UP000225825};
KW   Lyase {ECO:0000313|EMBL:CAL99691.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000006728}.
FT   DOMAIN      187    287       MR_MLE. {ECO:0000259|SMART:SM00922}.
SQ   SEQUENCE   448 AA;  48505 MW;  112F622A452F0D5B CRC64;
     MNTTTTQQSP VVTGMRVVPV AGRDSMLLNL SGAHAPHFTR NLLILTDSAG NTGVGEVPGG
     EGIRATLTDA TDLVVGAPIA RYHSVLTHVH RRFADRDSGG RGAQTFDLRV AVHAVTAVEA
     AMLDLLGKHL GVPVAELLGD GQQRESVPVL GYLFFVGDRN RTDLGYRSGA EESDDWLRLR
     DEEALTSDAV VRLAEAAQAR YGFHDFKLKG GVLPGREEAE VVTALAERFP EARITLDPNG
     GWLLSDAIEL GRDLYGVLAY AEDPCGPEGG YSGRETMAEF RRATGLPTAT NMIATDWRQL
     GHAVRTDAVD IPLADPHFWT MGGSVRVAQL CDAWGLTWGS HSNNHFDVSL AMFTHVAAAA
     PGDITAIDTH WIWQDGQRLT REPFRISDGR IEVPTAPGLG VELDMEQVEA AHALYLTEGL
     GTRDDAVAMR YLVPGWTFDS KRPALDRP
//

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