(data stored in SCRATCH zone)

SWISSPROT: KDGD_SACEN

ID   KDGD_SACEN              Reviewed;         309 AA.
AC   A4F6L9;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   17-APR-2007, sequence version 1.
DT   11-DEC-2019, entry version 69.
DE   RecName: Full=Probable 5-dehydro-4-deoxyglucarate dehydratase {ECO:0000255|HAMAP-Rule:MF_00694};
DE            EC=4.2.1.41 {ECO:0000255|HAMAP-Rule:MF_00694};
DE   AltName: Full=5-keto-4-deoxy-glucarate dehydratase {ECO:0000255|HAMAP-Rule:MF_00694};
DE            Short=KDGDH {ECO:0000255|HAMAP-Rule:MF_00694};
GN   OrderedLocusNames=SACE_0344;
OS   Saccharopolyspora erythraea (strain ATCC 11635 / DSM 40517 / JCM 4748 /
OS   NBRC 13426 / NCIMB 8594 / NRRL 2338).
OC   Bacteria; Actinobacteria; Pseudonocardiales; Pseudonocardiaceae;
OC   Saccharopolyspora.
OX   NCBI_TaxID=405948;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 11635 / DSM 40517 / JCM 4748 / NBRC 13426 / NCIMB 8594 / NRRL
RC   2338;
RX   PubMed=17369815; DOI=10.1038/nbt1297;
RA   Oliynyk M., Samborskyy M., Lester J.B., Mironenko T., Scott N., Dickens S.,
RA   Haydock S.F., Leadlay P.F.;
RT   "Complete genome sequence of the erythromycin-producing bacterium
RT   Saccharopolyspora erythraea NRRL23338.";
RL   Nat. Biotechnol. 25:447-453(2007).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=5-dehydro-4-deoxy-D-glucarate + H(+) = 2,5-dioxopentanoate +
CC         CO2 + H2O; Xref=Rhea:RHEA:24608, ChEBI:CHEBI:15377,
CC         ChEBI:CHEBI:15378, ChEBI:CHEBI:16526, ChEBI:CHEBI:42819,
CC         ChEBI:CHEBI:58136; EC=4.2.1.41; Evidence={ECO:0000255|HAMAP-
CC         Rule:MF_00694};
CC   -!- PATHWAY: Carbohydrate acid metabolism; D-glucarate degradation; 2,5-
CC       dioxopentanoate from D-glucarate: step 2/2. {ECO:0000255|HAMAP-
CC       Rule:MF_00694}.
CC   -!- SIMILARITY: Belongs to the DapA family. {ECO:0000255|HAMAP-
CC       Rule:MF_00694}.
DR   EMBL; AM420293; CAL99693.1; -; Genomic_DNA.
DR   RefSeq; WP_009946509.1; NZ_PDBV01000001.1.
DR   SMR; A4F6L9; -.
DR   STRING; 405948.SACE_0344; -.
DR   EnsemblBacteria; CAL99693; CAL99693; SACE_0344.
DR   KEGG; sen:SACE_0344; -.
DR   eggNOG; ENOG4105UVJ; Bacteria.
DR   eggNOG; COG0329; LUCA.
DR   HOGENOM; HOG000173605; -.
DR   KO; K01707; -.
DR   OMA; MVYNRDN; -.
DR   OrthoDB; 1438588at2; -.
DR   BioCyc; SERY405948:SACE_RS01685-MONOMER; -.
DR   UniPathway; UPA00564; UER00628.
DR   Proteomes; UP000006728; Chromosome.
DR   GO; GO:0047448; F:5-dehydro-4-deoxyglucarate dehydratase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0042838; P:D-glucarate catabolic process; IEA:UniProtKB-UniPathway.
DR   CDD; cd00951; KDGDH; 1.
DR   Gene3D; 3.20.20.70; -; 1.
DR   HAMAP; MF_00694; KDGDH; 1.
DR   InterPro; IPR013785; Aldolase_TIM.
DR   InterPro; IPR002220; DapA-like.
DR   InterPro; IPR017655; Dehydro-deoxyglucarate_dehyd.
DR   PANTHER; PTHR12128; PTHR12128; 1.
DR   Pfam; PF00701; DHDPS; 1.
DR   PIRSF; PIRSF001365; DHDPS; 1.
DR   SMART; SM01130; DHDPS; 1.
DR   TIGRFAMs; TIGR03249; KdgD; 1.
PE   3: Inferred from homology;
DR   PRODOM; A4F6L9.
DR   SWISS-2DPAGE; A4F6L9.
KW   Lyase; Reference proteome.
FT   CHAIN           1..309
FT                   /note="Probable 5-dehydro-4-deoxyglucarate dehydratase"
FT                   /id="PRO_1000045413"
SQ   SEQUENCE   309 AA;  33213 MW;  5B9DB6171154ADB7 CRC64;
     MSSYPPHEVA QRLASGLLSF PVTHFRADLT FDEPAYREHI GWLGQFGAAG LFAAGGTGEF
     FSLTPAEVET VVSAAVREVP DGLPVIAPAG YGTAMAVELA RAAERAGAHG ILLLPPYLTE
     ADQEGLAAHV RAVCAATGLG VILYSRANAV YTETTVARLA EDCPNLVGFK DGVGDIERMT
     RLYARLGDRL TYVGGLPTAE TFALPYLELG VTTYSSAMFN FVPRFALDFY DAVRRRDHAE
     VRRRLNDFVL PYCDIRNRRA GYAVSIVKAG MKVIGRPAGP VRSPLTDLDD AELAMLADLV
     KSMPATGEA
//

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