(data stored in ACNUC1104 zone)

SWISSPROT: A4F6R4_SACEN

ID   A4F6R4_SACEN            Unreviewed;       538 AA.
AC   A4F6R4;
DT   17-APR-2007, integrated into UniProtKB/TrEMBL.
DT   17-APR-2007, sequence version 1.
DT   08-MAY-2019, entry version 63.
DE   SubName: Full=EmrB/QacA subfamily drug resistance transporter {ECO:0000313|EMBL:PFG93541.1};
DE   SubName: Full=Multidrug transporter, MFS superfamily {ECO:0000313|EMBL:CAL99738.1};
GN   OrderedLocusNames=SACE_0390 {ECO:0000313|EMBL:CAL99738.1};
GN   ORFNames=A8924_0786 {ECO:0000313|EMBL:PFG93541.1};
OS   Saccharopolyspora erythraea (strain ATCC 11635 / DSM 40517 / JCM 4748
OS   / NBRC 13426 / NCIMB 8594 / NRRL 2338).
OC   Bacteria; Actinobacteria; Pseudonocardiales; Pseudonocardiaceae;
OC   Saccharopolyspora.
OX   NCBI_TaxID=405948 {ECO:0000313|EMBL:CAL99738.1, ECO:0000313|Proteomes:UP000006728};
RN   [1] {ECO:0000313|EMBL:CAL99738.1, ECO:0000313|Proteomes:UP000006728}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 11635 / DSM 40517 / JCM 4748 / NBRC 13426 / NCIMB 8594 /
RC   NRRL 2338 {ECO:0000313|Proteomes:UP000006728}, and NRRL 2338
RC   {ECO:0000313|EMBL:CAL99738.1};
RX   PubMed=17369815; DOI=10.1038/nbt1297;
RA   Oliynyk M., Samborskyy M., Lester J.B., Mironenko T., Scott N.,
RA   Dickens S., Haydock S.F., Leadlay P.F.;
RT   "Complete genome sequence of the erythromycin-producing bacterium
RT   Saccharopolyspora erythraea NRRL23338.";
RL   Nat. Biotechnol. 25:447-453(2007).
RN   [2] {ECO:0000313|EMBL:PFG93541.1, ECO:0000313|Proteomes:UP000225825}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 40517 {ECO:0000313|EMBL:PFG93541.1,
RC   ECO:0000313|Proteomes:UP000225825};
RA   Klenk H.-P.;
RT   "Sequencing the genomes of 1000 actinobacteria strains.";
RL   Submitted (SEP-2017) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the major facilitator superfamily.
CC       {ECO:0000256|SAAS:SAAS00769108}.
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DR   EMBL; AM420293; CAL99738.1; -; Genomic_DNA.
DR   EMBL; PDBV01000001; PFG93541.1; -; Genomic_DNA.
DR   RefSeq; WP_009946448.1; NZ_PDBV01000001.1.
DR   STRING; 405948.SACE_0390; -.
DR   EnsemblBacteria; CAL99738; CAL99738; SACE_0390.
DR   KEGG; sen:SACE_0390; -.
DR   eggNOG; ENOG4105C0R; Bacteria.
DR   eggNOG; ENOG410XNN3; LUCA.
DR   HOGENOM; HOG000239126; -.
DR   OMA; QDEITWV; -.
DR   OrthoDB; 1558246at2; -.
DR   BioCyc; SERY405948:SACE_RS01915-MONOMER; -.
DR   Proteomes; UP000006728; Chromosome.
DR   Proteomes; UP000225825; Unassembled WGS sequence.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR   GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR   CDD; cd06174; MFS; 1.
DR   InterPro; IPR004638; EmrB-like.
DR   InterPro; IPR011701; MFS.
DR   InterPro; IPR020846; MFS_dom.
DR   InterPro; IPR036259; MFS_trans_sf.
DR   InterPro; IPR001411; Tet-R_TetB/Drug-R_transptr.
DR   PANTHER; PTHR23501; PTHR23501; 1.
DR   Pfam; PF07690; MFS_1; 1.
DR   SUPFAM; SSF103473; SSF103473; 1.
DR   TIGRFAMs; TIGR00711; efflux_EmrB; 1.
DR   PROSITE; PS50850; MFS; 1.
PE   3: Inferred from homology;
DR   PRODOM; A4F6R4.
DR   SWISS-2DPAGE; A4F6R4.
KW   Cell membrane {ECO:0000256|SAAS:SAAS00769078};
KW   Complete proteome {ECO:0000313|Proteomes:UP000006728,
KW   ECO:0000313|Proteomes:UP000225825};
KW   Membrane {ECO:0000256|SAAS:SAAS00769060, ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000006728};
KW   Transmembrane {ECO:0000256|SAAS:SAAS00769091,
KW   ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAAS:SAAS00769070,
KW   ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|SAAS:SAAS00769034}.
FT   TRANSMEM     22     47       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM     59     78       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM     90    112       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    118    140       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    152    172       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    184    205       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    217    234       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    240    263       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    284    307       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    319    339       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    351    369       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    375    400       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    507    532       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN       25    537       MFS. {ECO:0000259|PROSITE:PS50850}.
SQ   SEQUENCE   538 AA;  57000 MW;  A1C100C164EC72DA CRC64;
     MSETAERAAP APPGVRLTHR QILTVLTGLM LGMFLGALDQ TIVSSAIRVI ADQLHGQTAQ
     AWVTTAYLIT ATITTPLYGK LSDIYGRKPL YLAAISLFLL GSVLCGLANS IYELAAFRAI
     QGLGGGGLMS LALTIIADML PPRERSRYQG YFMAVFGVSS VVGPVIGGLF AGMDSFLGFA
     GWRWVFLVNV PVGLIALVVV AKVLNVETER VRHRIDYWGA AALVVMLVPL LTVAEQGREW
     GWGSATSLAM YAIGAVGLVL FVVSERRMGD EALLPLRMFR LPSFRMGNVL NFIVGVGMFG
     GLMSMPLYLQ IVKGLDPTAA GMLMLTMTAG IMISTTIAGR AISKTGRLKP FPVIGSGIMT
     VALLLFSRLT ADTSLVQVGL IAVVMGLGLG LLMQTLTLVV QADATRTDLG VATASVNLFR
     QTGGTVGAAV FLSVLFSTVG GRIADAMRAA AVSPEFTAAL RDPAVLADPA NRDFLAGMRG
     GAPPDLNDTS FLYHLDPRLA RPVLEGFASA MGTVFFVGAC VVGVAFVLTW FLRDTRLD
//

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