(data stored in ACNUC1104 zone)

SWISSPROT: A4F6W8_SACEN

ID   A4F6W8_SACEN            Unreviewed;       321 AA.
AC   A4F6W8;
DT   17-APR-2007, integrated into UniProtKB/TrEMBL.
DT   17-APR-2007, sequence version 1.
DT   11-DEC-2019, entry version 79.
DE   SubName: Full=23S rRNA (Guanosine2251-2'-O)-methyltransferase {ECO:0000313|EMBL:PFG93594.1};
DE   SubName: Full=tRNA/rRNA methyltransferase {ECO:0000313|EMBL:CAL99792.1};
DE            EC=2.1.1.- {ECO:0000313|EMBL:CAL99792.1};
GN   OrderedLocusNames=SACE_0444 {ECO:0000313|EMBL:CAL99792.1};
GN   ORFNames=A8924_0841 {ECO:0000313|EMBL:PFG93594.1};
OS   Saccharopolyspora erythraea (strain ATCC 11635 / DSM 40517 / JCM 4748 /
OS   NBRC 13426 / NCIMB 8594 / NRRL 2338).
OC   Bacteria; Actinobacteria; Pseudonocardiales; Pseudonocardiaceae;
OC   Saccharopolyspora.
OX   NCBI_TaxID=405948 {ECO:0000313|EMBL:CAL99792.1, ECO:0000313|Proteomes:UP000006728};
RN   [1] {ECO:0000313|EMBL:CAL99792.1, ECO:0000313|Proteomes:UP000006728}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 11635 / DSM 40517 / JCM 4748 / NBRC 13426 / NCIMB 8594 /
RC   NRRL 2338 {ECO:0000313|Proteomes:UP000006728}, and NRRL 2338
RC   {ECO:0000313|EMBL:CAL99792.1};
RX   PubMed=17369815; DOI=10.1038/nbt1297;
RA   Oliynyk M., Samborskyy M., Lester J.B., Mironenko T., Scott N., Dickens S.,
RA   Haydock S.F., Leadlay P.F.;
RT   "Complete genome sequence of the erythromycin-producing bacterium
RT   Saccharopolyspora erythraea NRRL23338.";
RL   Nat. Biotechnol. 25:447-453(2007).
RN   [2] {ECO:0000313|EMBL:PFG93594.1, ECO:0000313|Proteomes:UP000225825}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 40517 {ECO:0000313|EMBL:PFG93594.1,
RC   ECO:0000313|Proteomes:UP000225825};
RA   Klenk H.-P.;
RT   "Sequencing the genomes of 1000 actinobacteria strains.";
RL   Submitted (SEP-2017) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the class IV-like SAM-binding methyltransferase
CC       superfamily. RNA methyltransferase TrmH family.
CC       {ECO:0000256|SAAS:SAAS00555714}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AM420293; CAL99792.1; -; Genomic_DNA.
DR   EMBL; PDBV01000001; PFG93594.1; -; Genomic_DNA.
DR   RefSeq; WP_009947438.1; NZ_PDBV01000001.1.
DR   STRING; 405948.SACE_0444; -.
DR   EnsemblBacteria; CAL99792; CAL99792; SACE_0444.
DR   KEGG; sen:SACE_0444; -.
DR   eggNOG; ENOG4105C2N; Bacteria.
DR   eggNOG; COG0566; LUCA.
DR   HOGENOM; HOG000218798; -.
DR   KO; K03218; -.
DR   OMA; QVPPYEY; -.
DR   OrthoDB; 1422015at2; -.
DR   BioCyc; SERY405948:SACE_RS02185-MONOMER; -.
DR   Proteomes; UP000006728; Chromosome.
DR   Proteomes; UP000225825; Unassembled WGS sequence.
DR   GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR   GO; GO:0008173; F:RNA methyltransferase activity; IEA:InterPro.
DR   GO; GO:0006396; P:RNA processing; IEA:InterPro.
DR   Gene3D; 3.30.1330.30; -; 1.
DR   Gene3D; 3.40.1280.10; -; 1.
DR   InterPro; IPR029028; Alpha/beta_knot_MTases.
DR   InterPro; IPR029064; L30e-like.
DR   InterPro; IPR004441; rRNA_MeTrfase_TrmH.
DR   InterPro; IPR001537; SpoU_MeTrfase.
DR   InterPro; IPR013123; SpoU_subst-bd.
DR   InterPro; IPR029026; tRNA_m1G_MTases_N.
DR   Pfam; PF00588; SpoU_methylase; 1.
DR   Pfam; PF08032; SpoU_sub_bind; 1.
DR   SMART; SM00967; SpoU_sub_bind; 1.
DR   SUPFAM; SSF55315; SSF55315; 1.
DR   SUPFAM; SSF75217; SSF75217; 1.
DR   TIGRFAMs; TIGR00186; rRNA_methyl_3; 1.
PE   3: Inferred from homology;
DR   PRODOM; A4F6W8.
DR   SWISS-2DPAGE; A4F6W8.
KW   Methyltransferase {ECO:0000256|SAAS:SAAS00477853,
KW   ECO:0000313|EMBL:CAL99792.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000006728};
KW   Transferase {ECO:0000256|SAAS:SAAS00477754, ECO:0000313|EMBL:CAL99792.1}.
FT   DOMAIN          78..154
FT                   /note="SpoU_sub_bind"
FT                   /evidence="ECO:0000259|SMART:SM00967"
FT   REGION          1..77
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        33..77
FT                   /note="Polyampholyte"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   321 AA;  33704 MW;  8D45EE43578A01DB CRC64;
     MAGNDRRRGA IRKPGSKKGM VVGSGGQRRR GLEGKGPTPK AKDRVSHPAK RKADAAKARA
     EQQRTRHRQK ERSDNAEVIA GRNPVAECIR AGVPASGLYV AQGIDADDRV TEAVRGAGSR
     GISVVEVQRA ELDRMTGGAM HQGLALQVPA YEYAHPEDVL TEAHNSGLPP LIVALDGVTD
     PRNLGAVIRS AAAFGAHGVI LPQRRSAGLT AVAWRTSAGT AAKLPVARAV NLTRTLKDLK
     SEGLMVVGLD ADSDITSDEL ELATGPLVVV VGSEGRGLSR LVRETCDQTV SIPMAGSVES
     LNASVAAGIV LAEVARRRRA R
//

If you have problems or comments...

PBIL Back to PBIL home page