(data stored in SCRATCH zone)

SWISSPROT: A4F726_SACEN

ID   A4F726_SACEN            Unreviewed;       377 AA.
AC   A4F726;
DT   17-APR-2007, integrated into UniProtKB/TrEMBL.
DT   17-APR-2007, sequence version 1.
DT   11-DEC-2019, entry version 70.
DE   SubName: Full=Serine protease {ECO:0000313|EMBL:CAL99850.1};
DE   SubName: Full=Streptogrisin C {ECO:0000313|EMBL:PFG93652.1};
GN   OrderedLocusNames=SACE_0504 {ECO:0000313|EMBL:CAL99850.1};
GN   ORFNames=A8924_0902 {ECO:0000313|EMBL:PFG93652.1};
OS   Saccharopolyspora erythraea (strain ATCC 11635 / DSM 40517 / JCM 4748 /
OS   NBRC 13426 / NCIMB 8594 / NRRL 2338).
OC   Bacteria; Actinobacteria; Pseudonocardiales; Pseudonocardiaceae;
OC   Saccharopolyspora.
OX   NCBI_TaxID=405948 {ECO:0000313|EMBL:CAL99850.1, ECO:0000313|Proteomes:UP000006728};
RN   [1] {ECO:0000313|EMBL:CAL99850.1, ECO:0000313|Proteomes:UP000006728}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 11635 / DSM 40517 / JCM 4748 / NBRC 13426 / NCIMB 8594 /
RC   NRRL 2338 {ECO:0000313|Proteomes:UP000006728}, and NRRL 2338
RC   {ECO:0000313|EMBL:CAL99850.1};
RX   PubMed=17369815; DOI=10.1038/nbt1297;
RA   Oliynyk M., Samborskyy M., Lester J.B., Mironenko T., Scott N., Dickens S.,
RA   Haydock S.F., Leadlay P.F.;
RT   "Complete genome sequence of the erythromycin-producing bacterium
RT   Saccharopolyspora erythraea NRRL23338.";
RL   Nat. Biotechnol. 25:447-453(2007).
RN   [2] {ECO:0000313|EMBL:PFG93652.1, ECO:0000313|Proteomes:UP000225825}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 40517 {ECO:0000313|EMBL:PFG93652.1,
RC   ECO:0000313|Proteomes:UP000225825};
RA   Klenk H.-P.;
RT   "Sequencing the genomes of 1000 actinobacteria strains.";
RL   Submitted (SEP-2017) to the EMBL/GenBank/DDBJ databases.
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DR   EMBL; AM420293; CAL99850.1; -; Genomic_DNA.
DR   EMBL; PDBV01000001; PFG93652.1; -; Genomic_DNA.
DR   RefSeq; WP_011873078.1; NZ_PDBV01000001.1.
DR   STRING; 405948.SACE_0504; -.
DR   EnsemblBacteria; CAL99850; CAL99850; SACE_0504.
DR   KEGG; sen:SACE_0504; -.
DR   eggNOG; ENOG4106T9R; Bacteria.
DR   eggNOG; ENOG410XQ6H; LUCA.
DR   HOGENOM; HOG000253137; -.
DR   OMA; RTTGWRC; -.
DR   OrthoDB; 1110723at2; -.
DR   BioCyc; SERY405948:SACE_RS02475-MONOMER; -.
DR   Proteomes; UP000006728; Chromosome.
DR   Proteomes; UP000225825; Unassembled WGS sequence.
DR   GO; GO:0005576; C:extracellular region; IEA:InterPro.
DR   GO; GO:0004252; F:serine-type endopeptidase activity; IEA:InterPro.
DR   Gene3D; 3.30.300.50; -; 2.
DR   InterPro; IPR037295; Alpha-lytic_protease_prodomain.
DR   InterPro; IPR004236; Pept_S1_alpha_lytic.
DR   InterPro; IPR001316; Pept_S1A_streptogrisin.
DR   InterPro; IPR009003; Peptidase_S1_PA.
DR   InterPro; IPR035070; Streptogrisin_prodomain.
DR   Pfam; PF02983; Pro_Al_protease; 1.
DR   PIRSF; PIRSF001134; Streptogrisin; 1.
DR   PRINTS; PR00861; ALYTICPTASE.
DR   SUPFAM; SSF50494; SSF50494; 1.
DR   SUPFAM; SSF54806; SSF54806; 1.
PE   4: Predicted;
DR   PRODOM; A4F726.
DR   SWISS-2DPAGE; A4F726.
KW   Disulfide bond {ECO:0000256|PIRSR:PIRSR001134-2};
KW   Hydrolase {ECO:0000313|EMBL:CAL99850.1};
KW   Protease {ECO:0000313|EMBL:CAL99850.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000006728};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL          1..29
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           30..377
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5011934046"
FT   DOMAIN          121..179
FT                   /note="Pro_Al_protease"
FT                   /evidence="ECO:0000259|Pfam:PF02983"
FT   ACT_SITE        226
FT                   /note="Charge relay system"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR001134-1"
FT   ACT_SITE        250
FT                   /note="Charge relay system"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR001134-1"
FT   ACT_SITE        331
FT                   /note="Charge relay system"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR001134-1"
FT   DISULFID        211..227
FT                   /evidence="ECO:0000256|PIRSR:PIRSR001134-2"
FT   DISULFID        289..299
FT                   /evidence="ECO:0000256|PIRSR:PIRSR001134-2"
FT   DISULFID        325..352
FT                   /evidence="ECO:0000256|PIRSR:PIRSR001134-2"
SQ   SEQUENCE   377 AA;  37943 MW;  E5647E77B16680CD CRC64;
     MKRRLAARVT GSVIFAAGTI AALTVPATAN PTAPAPVAAE AATLMEAMQR DLGLTAEQAA
     ERLADEAAAT RADQSLRGTL GSAFGGSHYD AALGKLVVGV TDAGLLDEVR AAGADGELVQ
     HNVQQLDGVA DGLDAQSARA PQSVTGWYVD SSSNSVVLTT APGTAGQATD FVRASGVDAG
     AVRVVESAEQ PRTYADVIGG DAYYIGSGSR CSVGFSVQGG FVTAGHCGNQ GDSTSQPSGT
     FEGSSFPGND YGWVRTASGE NPVPLVNDYQ GGTVGVAGSS EAAEGASICR SGSTTGWHCG
     TVEAKNQTVR YPQGTVEGLT RTNVCAEPGD SGGSWLSGDQ AQGVTSGGSG DCTSGGTTYF
     QPVNEILQAY GLTLLTQ
//

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