(data stored in ACNUC1104 zone)

SWISSPROT: A4F779_SACEN

ID   A4F779_SACEN            Unreviewed;      1128 AA.
AC   A4F779;
DT   17-APR-2007, integrated into UniProtKB/TrEMBL.
DT   17-APR-2007, sequence version 1.
DT   08-MAY-2019, entry version 91.
DE   RecName: Full=Histidine kinase {ECO:0000256|SAAS:SAAS00924638};
DE            EC=2.7.13.3 {ECO:0000256|SAAS:SAAS00924638};
GN   OrderedLocusNames=SACE_0557 {ECO:0000313|EMBL:CAL99903.1};
GN   ORFNames=A8924_0957 {ECO:0000313|EMBL:PFG93706.1};
OS   Saccharopolyspora erythraea (strain ATCC 11635 / DSM 40517 / JCM 4748
OS   / NBRC 13426 / NCIMB 8594 / NRRL 2338).
OC   Bacteria; Actinobacteria; Pseudonocardiales; Pseudonocardiaceae;
OC   Saccharopolyspora.
OX   NCBI_TaxID=405948 {ECO:0000313|EMBL:CAL99903.1, ECO:0000313|Proteomes:UP000006728};
RN   [1] {ECO:0000313|EMBL:CAL99903.1, ECO:0000313|Proteomes:UP000006728}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 11635 / DSM 40517 / JCM 4748 / NBRC 13426 / NCIMB 8594 /
RC   NRRL 2338 {ECO:0000313|Proteomes:UP000006728}, and NRRL 2338
RC   {ECO:0000313|EMBL:CAL99903.1};
RX   PubMed=17369815; DOI=10.1038/nbt1297;
RA   Oliynyk M., Samborskyy M., Lester J.B., Mironenko T., Scott N.,
RA   Dickens S., Haydock S.F., Leadlay P.F.;
RT   "Complete genome sequence of the erythromycin-producing bacterium
RT   Saccharopolyspora erythraea NRRL23338.";
RL   Nat. Biotechnol. 25:447-453(2007).
RN   [2] {ECO:0000313|EMBL:PFG93706.1, ECO:0000313|Proteomes:UP000225825}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 40517 {ECO:0000313|EMBL:PFG93706.1,
RC   ECO:0000313|Proteomes:UP000225825};
RA   Klenk H.-P.;
RT   "Sequencing the genomes of 1000 actinobacteria strains.";
RL   Submitted (SEP-2017) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + protein L-histidine = ADP + protein N-phospho-L-
CC         histidine.; EC=2.7.13.3;
CC         Evidence={ECO:0000256|SAAS:SAAS01126420};
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DR   EMBL; AM420293; CAL99903.1; -; Genomic_DNA.
DR   EMBL; PDBV01000001; PFG93706.1; -; Genomic_DNA.
DR   RefSeq; WP_009945217.1; NZ_PDBV01000001.1.
DR   STRING; 405948.SACE_0557; -.
DR   EnsemblBacteria; CAL99903; CAL99903; SACE_0557.
DR   KEGG; sen:SACE_0557; -.
DR   eggNOG; ENOG4105CM5; Bacteria.
DR   eggNOG; ENOG410XSDD; LUCA.
DR   HOGENOM; HOG000253142; -.
DR   OMA; SVGVHSR; -.
DR   OrthoDB; 811938at2; -.
DR   BioCyc; SERY405948:SACE_RS02740-MONOMER; -.
DR   Proteomes; UP000006728; Chromosome.
DR   Proteomes; UP000225825; Unassembled WGS sequence.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0004673; F:protein histidine kinase activity; IEA:UniProtKB-EC.
DR   GO; GO:0000160; P:phosphorelay signal transduction system; IEA:UniProtKB-KW.
DR   CDD; cd00075; HATPase_c; 1.
DR   Gene3D; 3.30.565.10; -; 1.
DR   InterPro; IPR003660; HAMP_dom.
DR   InterPro; IPR003594; HATPase_C.
DR   InterPro; IPR036890; HATPase_C_sf.
DR   InterPro; IPR013587; Nitrate/nitrite_sensing.
DR   Pfam; PF00672; HAMP; 1.
DR   Pfam; PF02518; HATPase_c; 1.
DR   Pfam; PF08376; NIT; 1.
DR   SMART; SM00304; HAMP; 1.
DR   SMART; SM00387; HATPase_c; 1.
DR   SUPFAM; SSF55874; SSF55874; 1.
PE   4: Predicted;
DR   PRODOM; A4F779.
DR   SWISS-2DPAGE; A4F779.
KW   ATP-binding {ECO:0000256|SAAS:SAAS01002602};
KW   Complete proteome {ECO:0000313|Proteomes:UP000006728,
KW   ECO:0000313|Proteomes:UP000225825};
KW   Kinase {ECO:0000256|SAAS:SAAS00924871, ECO:0000313|EMBL:CAL99903.1};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Nucleotide-binding {ECO:0000256|SAAS:SAAS01002785};
KW   Reference proteome {ECO:0000313|Proteomes:UP000006728};
KW   Transferase {ECO:0000256|SAAS:SAAS00924820};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius};
KW   Two-component regulatory system {ECO:0000256|SAAS:SAAS00924981}.
FT   TRANSMEM     37     57       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    336    354       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN      355    425       HAMP. {ECO:0000259|SMART:SM00304}.
FT   DOMAIN      537    649       HATPase_c. {ECO:0000259|SMART:SM00387}.
SQ   SEQUENCE   1128 AA;  121827 MW;  B019B87D73747CBF CRC64;
     MLNNDPGTGG RQDRRVEAQD PHSKRWWLRN WRLRTKMAAV LLVPTLAALG VGGIRVYDGM
     STADRLNTIV EQVELAQRTA DITHELQRER DHAVVQTASG GADRVPYDDQ ARRVDDAIAR
     FRLPESELED FTPKVREAYQ SALNRLSSLN SLRAIVNRGF TDSQTLVAYN SVVESVLNVP
     RAVSSGAANT QLTQSAWAAE SISRAKEYLA QQRSILLSAG IRNEFFTGQV AQMREADARF
     EAAFTEFENV ASPAQRELYA ARVAGAAVDD SEQIKQYALI NAENDRALNM NPGEWGAASG
     TRGDLLRGVE EEVLGEFHDT AKQYADAAWW SMLRDGALIV LLLLVAFAVA SYIARSMLRP
     LRTLRYGALE IAEQSLPQAI KQVNENPSGA SSVTVPPVPV HTREEIGQVA RSFDAVHQQA
     LRLASEQALL RTNVNDLFVN LARRSQTLVQ RQLSLIDRLE QDEQDPDQLS SLFELDHLAT
     RMRRNNENLL ILGGTDLTRR MMRPVPLSEV VGAAVSEVEQ YARIAIAESP DLAIQGRVVN
     DFVHLIAELL ENATVFSNPD TEVTVRTAYR RQELVIEIRD RGVGIDDEEI DEINDRLTRP
     PEVDVAVSRR MGLFVVGQLA RRHNIGVQLQ NNGDLEGGVT ATVHLSGEYV VQLTADGPRP
     MPDIGRPVGG DEPKRDPLSE TGTHLGLAAA FGSRGGAADR GVDAPTERAP LPPLNFDSPG
     APAPSAPAPS SNGFDPSGGP LPQRRKESPA AQEAEEQEPV EDLPGNYSFQ VSSGGSFGAT
     DIPKWEDDAE ASTDDDVRAE QWPSAESAAA AEDRELPAAF DGQCGVPAQE EEESPSLFHS
     PFEAEKTATF EAARPDPDSD GADQNGTRPA PDAPLAAGAT QDAQDAPGEL RASTASDYET
     EGQPPAVDTQ PKGASWDMDD APTQRLPIYE AVLSQWFRES DVDEGGSPLG DSLSSGGGQP
     PRPARQEAPA EPPSVADGEQ ALQARRAAEP ESETGELRAT GASGPGGETG EFPEELLAPT
     GPRDPGWGSA DVGWQAAEAL VQQSQQVQET TSAGLPKRVP KSNLVPGSAA PRPQSPAPAK
     PATTRSPDAV RGRMSNFQQG IRRGRHAKAD PVSTEPPRSI PSRHEEQE
//

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