(data stored in ACNUC1104 zone)

SWISSPROT: A4F7E6_SACEN

ID   A4F7E6_SACEN            Unreviewed;       430 AA.
AC   A4F7E6;
DT   17-APR-2007, integrated into UniProtKB/TrEMBL.
DT   17-APR-2007, sequence version 1.
DT   08-MAY-2019, entry version 66.
DE   RecName: Full=Bcr/CflA family efflux transporter {ECO:0000256|RuleBase:RU365088};
GN   OrderedLocusNames=SACE_0625 {ECO:0000313|EMBL:CAL99970.1};
GN   ORFNames=A8924_1024 {ECO:0000313|EMBL:PFG93772.1};
OS   Saccharopolyspora erythraea (strain ATCC 11635 / DSM 40517 / JCM 4748
OS   / NBRC 13426 / NCIMB 8594 / NRRL 2338).
OC   Bacteria; Actinobacteria; Pseudonocardiales; Pseudonocardiaceae;
OC   Saccharopolyspora.
OX   NCBI_TaxID=405948 {ECO:0000313|EMBL:CAL99970.1, ECO:0000313|Proteomes:UP000006728};
RN   [1] {ECO:0000313|EMBL:CAL99970.1, ECO:0000313|Proteomes:UP000006728}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 11635 / DSM 40517 / JCM 4748 / NBRC 13426 / NCIMB 8594 /
RC   NRRL 2338 {ECO:0000313|Proteomes:UP000006728}, and NRRL 2338
RC   {ECO:0000313|EMBL:CAL99970.1};
RX   PubMed=17369815; DOI=10.1038/nbt1297;
RA   Oliynyk M., Samborskyy M., Lester J.B., Mironenko T., Scott N.,
RA   Dickens S., Haydock S.F., Leadlay P.F.;
RT   "Complete genome sequence of the erythromycin-producing bacterium
RT   Saccharopolyspora erythraea NRRL23338.";
RL   Nat. Biotechnol. 25:447-453(2007).
RN   [2] {ECO:0000313|EMBL:PFG93772.1, ECO:0000313|Proteomes:UP000225825}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 40517 {ECO:0000313|EMBL:PFG93772.1,
RC   ECO:0000313|Proteomes:UP000225825};
RA   Klenk H.-P.;
RT   "Sequencing the genomes of 1000 actinobacteria strains.";
RL   Submitted (SEP-2017) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Cell membrane
CC       {ECO:0000256|RuleBase:RU365088}; Multi-pass membrane protein
CC       {ECO:0000256|RuleBase:RU365088}.
CC   -!- SIMILARITY: Belongs to the major facilitator superfamily. Bcr/CmlA
CC       family. {ECO:0000256|RuleBase:RU365088}.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   -----------------------------------------------------------------------
DR   EMBL; AM420293; CAL99970.1; -; Genomic_DNA.
DR   EMBL; PDBV01000001; PFG93772.1; -; Genomic_DNA.
DR   RefSeq; WP_011873108.1; NZ_PDBV01000001.1.
DR   STRING; 405948.SACE_0625; -.
DR   EnsemblBacteria; CAL99970; CAL99970; SACE_0625.
DR   KEGG; sen:SACE_0625; -.
DR   eggNOG; ENOG4105C2C; Bacteria.
DR   eggNOG; ENOG410XNNX; LUCA.
DR   HOGENOM; HOG000143170; -.
DR   KO; K07552; -.
DR   OMA; IEYFHVS; -.
DR   OrthoDB; 1452500at2; -.
DR   BioCyc; SERY405948:SACE_RS03075-MONOMER; -.
DR   Proteomes; UP000006728; Chromosome.
DR   Proteomes; UP000225825; Unassembled WGS sequence.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-UniRule.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0015238; F:drug transmembrane transporter activity; IEA:UniProtKB-UniRule.
DR   CDD; cd06174; MFS; 1.
DR   InterPro; IPR004812; Efflux_drug-R_Bcr/CmlA.
DR   InterPro; IPR011701; MFS.
DR   InterPro; IPR020846; MFS_dom.
DR   InterPro; IPR036259; MFS_trans_sf.
DR   InterPro; IPR005829; Sugar_transporter_CS.
DR   Pfam; PF07690; MFS_1; 1.
DR   SUPFAM; SSF103473; SSF103473; 1.
DR   TIGRFAMs; TIGR00710; efflux_Bcr_CflA; 1.
DR   PROSITE; PS50850; MFS; 1.
DR   PROSITE; PS00216; SUGAR_TRANSPORT_1; 1.
PE   3: Inferred from homology;
DR   PRODOM; A4F7E6.
DR   SWISS-2DPAGE; A4F7E6.
KW   Cell membrane {ECO:0000256|RuleBase:RU365088};
KW   Complete proteome {ECO:0000313|Proteomes:UP000006728,
KW   ECO:0000313|Proteomes:UP000225825};
KW   Membrane {ECO:0000256|RuleBase:RU365088};
KW   Reference proteome {ECO:0000313|Proteomes:UP000006728};
KW   Transmembrane {ECO:0000256|RuleBase:RU365088};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU365088};
KW   Transport {ECO:0000256|RuleBase:RU365088}.
FT   TRANSMEM     20     37       Helical. {ECO:0000256|RuleBase:RU365088}.
FT   TRANSMEM     57     76       Helical. {ECO:0000256|RuleBase:RU365088}.
FT   TRANSMEM     88    107       Helical. {ECO:0000256|RuleBase:RU365088}.
FT   TRANSMEM    113    134       Helical. {ECO:0000256|RuleBase:RU365088}.
FT   TRANSMEM    146    170       Helical. {ECO:0000256|RuleBase:RU365088}.
FT   TRANSMEM    176    196       Helical. {ECO:0000256|RuleBase:RU365088}.
FT   TRANSMEM    217    242       Helical. {ECO:0000256|RuleBase:RU365088}.
FT   TRANSMEM    262    281       Helical. {ECO:0000256|RuleBase:RU365088}.
FT   TRANSMEM    293    314       Helical. {ECO:0000256|RuleBase:RU365088}.
FT   TRANSMEM    320    344       Helical. {ECO:0000256|RuleBase:RU365088}.
FT   TRANSMEM    356    375       Helical. {ECO:0000256|RuleBase:RU365088}.
FT   TRANSMEM    381    402       Helical. {ECO:0000256|RuleBase:RU365088}.
FT   DOMAIN       20    408       MFS. {ECO:0000259|PROSITE:PS50850}.
SQ   SEQUENCE   430 AA;  43890 MW;  7A209C006C2EC858 CRC64;
     MPRAEEEAVE AGNSSLSRKA RFALILGGLT AFGPLSIDMY LPALPELTRE LGATEAQAQL
     TLTAVLLGLA FGQLFAGPVS DAVGRRKPLL AGLAVYIAAT VLCALTESVH TLAVLRAVQG
     FGAAAGMVIA RASVRDLYSG AEAARFFSSL MLVVGLAPIL APVIGGQVLA HTTWRGVFVV
     LTAFGVVLMA VAAFALPETK PKQWRQPARI GSTFRTFGTL LAKPSFLGCA LAAGLAMAAM
     FAYVSGSSFV MQNIYGMSPQ TYAMVFGANA IGLVAAGQVN ARLVGRVATE AQLLTTALLT
     ASVAGAVLVT TALLGLPLPV LLGALFVMIS SLGFVMPNTT TLALAEHREV SGSASALLGV
     SQFVVGALAA PLVGMGGVGS ALPMVSVMFG VILASAAVFL TLGRRGGPSQ RIVATRTSGS
     ARAEVAATER
//

If you have problems or comments...

PBIL Back to PBIL home page