(data stored in ACNUC1104 zone)

SWISSPROT: A4F7G9_SACEN

ID   A4F7G9_SACEN            Unreviewed;       434 AA.
AC   A4F7G9;
DT   17-APR-2007, integrated into UniProtKB/TrEMBL.
DT   17-APR-2007, sequence version 1.
DT   11-DEC-2019, entry version 91.
DE   RecName: Full=Citrate synthase {ECO:0000256|PIRNR:PIRNR001369, ECO:0000256|RuleBase:RU003370};
GN   Name=gltA-2 {ECO:0000313|EMBL:CAL99993.1};
GN   OrderedLocusNames=SACE_0649 {ECO:0000313|EMBL:CAL99993.1};
GN   ORFNames=A8924_1047 {ECO:0000313|EMBL:PFG93795.1};
OS   Saccharopolyspora erythraea (strain ATCC 11635 / DSM 40517 / JCM 4748 /
OS   NBRC 13426 / NCIMB 8594 / NRRL 2338).
OC   Bacteria; Actinobacteria; Pseudonocardiales; Pseudonocardiaceae;
OC   Saccharopolyspora.
OX   NCBI_TaxID=405948 {ECO:0000313|EMBL:CAL99993.1, ECO:0000313|Proteomes:UP000006728};
RN   [1] {ECO:0000313|EMBL:CAL99993.1, ECO:0000313|Proteomes:UP000006728}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 11635 / DSM 40517 / JCM 4748 / NBRC 13426 / NCIMB 8594 /
RC   NRRL 2338 {ECO:0000313|Proteomes:UP000006728}, and NRRL 2338
RC   {ECO:0000313|EMBL:CAL99993.1};
RX   PubMed=17369815; DOI=10.1038/nbt1297;
RA   Oliynyk M., Samborskyy M., Lester J.B., Mironenko T., Scott N., Dickens S.,
RA   Haydock S.F., Leadlay P.F.;
RT   "Complete genome sequence of the erythromycin-producing bacterium
RT   Saccharopolyspora erythraea NRRL23338.";
RL   Nat. Biotechnol. 25:447-453(2007).
RN   [2] {ECO:0000313|EMBL:PFG93795.1, ECO:0000313|Proteomes:UP000225825}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 40517 {ECO:0000313|EMBL:PFG93795.1,
RC   ECO:0000313|Proteomes:UP000225825};
RA   Klenk H.-P.;
RT   "Sequencing the genomes of 1000 actinobacteria strains.";
RL   Submitted (SEP-2017) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=acetyl-CoA + H2O + oxaloacetate = citrate + CoA + H(+);
CC         Xref=Rhea:RHEA:16845, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:16452, ChEBI:CHEBI:16947, ChEBI:CHEBI:57287,
CC         ChEBI:CHEBI:57288; EC=2.3.3.16;
CC         Evidence={ECO:0000256|RuleBase:RU003370};
CC   -!- PATHWAY: Carbohydrate metabolism; tricarboxylic acid cycle; isocitrate
CC       from oxaloacetate: step 1/2. {ECO:0000256|RuleBase:RU003370}.
CC   -!- SIMILARITY: Belongs to the citrate synthase family.
CC       {ECO:0000256|PIRNR:PIRNR001369, ECO:0000256|RuleBase:RU003406}.
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DR   EMBL; AM420293; CAL99993.1; -; Genomic_DNA.
DR   EMBL; PDBV01000001; PFG93795.1; -; Genomic_DNA.
DR   RefSeq; WP_009950023.1; NZ_PDBV01000001.1.
DR   STRING; 405948.SACE_0649; -.
DR   EnsemblBacteria; CAL99993; CAL99993; SACE_0649.
DR   KEGG; sen:SACE_0649; -.
DR   eggNOG; ENOG4105BZN; Bacteria.
DR   eggNOG; COG0372; LUCA.
DR   HOGENOM; HOG000021224; -.
DR   KO; K01647; -.
DR   OMA; TVGWCAQ; -.
DR   OrthoDB; 1412360at2; -.
DR   BioCyc; SERY405948:SACE_RS03190-MONOMER; -.
DR   UniPathway; UPA00223; UER00717.
DR   Proteomes; UP000006728; Chromosome.
DR   Proteomes; UP000225825; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:InterPro.
DR   GO; GO:0004108; F:citrate (Si)-synthase activity; IEA:InterPro.
DR   GO; GO:0006099; P:tricarboxylic acid cycle; IEA:UniProtKB-UniPathway.
DR   Gene3D; 1.10.230.10; -; 1.
DR   Gene3D; 1.10.580.10; -; 1.
DR   InterPro; IPR016142; Citrate_synth-like_lrg_a-sub.
DR   InterPro; IPR016143; Citrate_synth-like_sm_a-sub.
DR   InterPro; IPR002020; Citrate_synthase.
DR   InterPro; IPR019810; Citrate_synthase_AS.
DR   InterPro; IPR024176; Citrate_synthase_bac-typ.
DR   InterPro; IPR036969; Citrate_synthase_sf.
DR   InterPro; IPR010953; Citrate_synthase_typ-I.
DR   Pfam; PF00285; Citrate_synt; 1.
DR   PIRSF; PIRSF001369; Citrate_synth; 1.
DR   PRINTS; PR00143; CITRTSNTHASE.
DR   SUPFAM; SSF48256; SSF48256; 1.
DR   TIGRFAMs; TIGR01798; cit_synth_I; 1.
DR   PROSITE; PS00480; CITRATE_SYNTHASE; 1.
PE   3: Inferred from homology;
DR   PRODOM; A4F7G9.
DR   SWISS-2DPAGE; A4F7G9.
KW   Acyltransferase {ECO:0000313|EMBL:CAL99993.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000006728};
KW   Transferase {ECO:0000256|PIRNR:PIRNR001369, ECO:0000256|RuleBase:RU003370,
KW   ECO:0000313|EMBL:CAL99993.1};
KW   Tricarboxylic acid cycle {ECO:0000256|RuleBase:RU003370}.
FT   ACT_SITE        312
FT                   /evidence="ECO:0000256|PIRSR:PIRSR001369-1"
FT   ACT_SITE        369
FT                   /evidence="ECO:0000256|PIRSR:PIRSR001369-1"
SQ   SEQUENCE   434 AA;  48296 MW;  FFCA8C8C6DC62FA7 CRC64;
     MPDDATTKRT VALRYDGGEH EMQVTQPTEG APGVDLGKLL AQTGLVTLDP GFVNTAACTS
     DITYIDGDAG ILRYRGYPIE ELAAKSNFIE VSYLLIYGEL PTQQQYEDFA ERIRRHTLLH
     EDLKQFFDGF PRDAHPMPVL SSAVSALSTF YQDSLNPFDA NQVELSTVRL LAKLPTIAAY
     AYKKSVGQPF LYPDNSLGLV ENFLRMTFGF PAEPYEVDPT LTRALDLLFI LHADHEQNCS
     TSTVRMVGSS EANLFASISA GINALFGPLH GGANSAVLEM LEGINRNGGD VDSFVNRVKN
     KEPGVKLMGF GHRVYKNYDP RAAIIKKTAD EVLGKLSAND PLLDIALKLE EKALADDYFV
     ERKLYPNVDF YTGLIYKAMG FPTKFFTVLF ALGRLPGWIA HWREMLEDPA RKISRPRQVY
     TGQAERSYTP IAQR
//

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