(data stored in ACNUC1104 zone)

SWISSPROT: A4F7L7_SACEN

ID   A4F7L7_SACEN            Unreviewed;       250 AA.
AC   A4F7L7;
DT   17-APR-2007, integrated into UniProtKB/TrEMBL.
DT   17-APR-2007, sequence version 1.
DT   08-MAY-2019, entry version 61.
DE   SubName: Full=2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase {ECO:0000313|EMBL:CAM00041.1};
DE            EC=4.1.2.20 {ECO:0000313|EMBL:CAM00041.1};
DE   SubName: Full=4-hydroxy-2-oxoheptanedioate aldolase {ECO:0000313|EMBL:PFG93845.1};
GN   OrderedLocusNames=SACE_0699 {ECO:0000313|EMBL:CAM00041.1};
GN   ORFNames=A8924_1097 {ECO:0000313|EMBL:PFG93845.1};
OS   Saccharopolyspora erythraea (strain ATCC 11635 / DSM 40517 / JCM 4748
OS   / NBRC 13426 / NCIMB 8594 / NRRL 2338).
OC   Bacteria; Actinobacteria; Pseudonocardiales; Pseudonocardiaceae;
OC   Saccharopolyspora.
OX   NCBI_TaxID=405948 {ECO:0000313|EMBL:CAM00041.1, ECO:0000313|Proteomes:UP000006728};
RN   [1] {ECO:0000313|EMBL:CAM00041.1, ECO:0000313|Proteomes:UP000006728}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 11635 / DSM 40517 / JCM 4748 / NBRC 13426 / NCIMB 8594 /
RC   NRRL 2338 {ECO:0000313|Proteomes:UP000006728}, and NRRL 2338
RC   {ECO:0000313|EMBL:CAM00041.1};
RX   PubMed=17369815; DOI=10.1038/nbt1297;
RA   Oliynyk M., Samborskyy M., Lester J.B., Mironenko T., Scott N.,
RA   Dickens S., Haydock S.F., Leadlay P.F.;
RT   "Complete genome sequence of the erythromycin-producing bacterium
RT   Saccharopolyspora erythraea NRRL23338.";
RL   Nat. Biotechnol. 25:447-453(2007).
RN   [2] {ECO:0000313|EMBL:PFG93845.1, ECO:0000313|Proteomes:UP000225825}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 40517 {ECO:0000313|EMBL:PFG93845.1,
RC   ECO:0000313|Proteomes:UP000225825};
RA   Klenk H.-P.;
RT   "Sequencing the genomes of 1000 actinobacteria strains.";
RL   Submitted (SEP-2017) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the HpcH/HpaI aldolase family.
CC       {ECO:0000256|SAAS:SAAS00571010}.
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DR   EMBL; AM420293; CAM00041.1; -; Genomic_DNA.
DR   EMBL; PDBV01000001; PFG93845.1; -; Genomic_DNA.
DR   RefSeq; WP_009950550.1; NZ_PDBV01000001.1.
DR   STRING; 405948.SACE_0699; -.
DR   EnsemblBacteria; CAM00041; CAM00041; SACE_0699.
DR   KEGG; sen:SACE_0699; -.
DR   eggNOG; ENOG4105CNV; Bacteria.
DR   eggNOG; COG3836; LUCA.
DR   HOGENOM; HOG000179751; -.
DR   KO; K02510; -.
DR   OrthoDB; 1797448at2; -.
DR   BioCyc; SERY405948:SACE_RS03435-MONOMER; -.
DR   Proteomes; UP000006728; Chromosome.
DR   Proteomes; UP000225825; Unassembled WGS sequence.
DR   GO; GO:0008672; F:2-dehydro-3-deoxyglucarate aldolase activity; IEA:UniProtKB-EC.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   Gene3D; 3.20.20.60; -; 1.
DR   InterPro; IPR005000; Aldolase/citrate-lyase_domain.
DR   InterPro; IPR015813; Pyrv/PenolPyrv_Kinase-like_dom.
DR   InterPro; IPR040442; Pyrv_Kinase-like_dom_sf.
DR   Pfam; PF03328; HpcH_HpaI; 1.
DR   SUPFAM; SSF51621; SSF51621; 1.
PE   3: Inferred from homology;
DR   PRODOM; A4F7L7.
DR   SWISS-2DPAGE; A4F7L7.
KW   Complete proteome {ECO:0000313|Proteomes:UP000006728,
KW   ECO:0000313|Proteomes:UP000225825};
KW   Lyase {ECO:0000313|EMBL:CAM00041.1};
KW   Metal-binding {ECO:0000256|SAAS:SAAS00460587};
KW   Reference proteome {ECO:0000313|Proteomes:UP000006728}.
FT   DOMAIN       21    234       HpcH_HpaI. {ECO:0000259|Pfam:PF03328}.
SQ   SEQUENCE   250 AA;  26703 MW;  564F8CBB632231DD CRC64;
     MRRELLESGR TTHGGWCCLP GPITAEVMGR AGFDWVCVDT QHGLIGYDVL PSMLQALALT
     GTPALVRVPW NQPAEIMRAL DAGASGVIVP MVQSAREAEQ AVRACRYPPQ GERSFGPMAP
     LMRDRGFSTT KANDEVLCAV QIETRSTLDE LDEILSVPGV DVAYVGPADL GISLGVAPTL
     DVVEPGHLAA VERVLSACQE HDVIPGIHCA DPRGARRWRD MGFRLLAVAT DVRLLELSAA
     EAVTGAGLSR
//

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