(data stored in ACNUC8465 zone)

SWISSPROT: B6HGC5_PENRW

ID   B6HGC5_PENRW            Unreviewed;       256 AA.
AC   B6HGC5;
DT   16-DEC-2008, integrated into UniProtKB/TrEMBL.
DT   16-DEC-2008, sequence version 1.
DT   07-JUN-2017, entry version 45.
DE   RecName: Full=Derlin {ECO:0000256|RuleBase:RU363059};
GN   ORFNames=Pc20g00740 {ECO:0000313|EMBL:CAP85403.1}, PCH_Pc20g00740
GN   {ECO:0000313|EMBL:CAP85403.1};
OS   Penicillium rubens (strain ATCC 28089 / DSM 1075 / NRRL 1951 /
OS   Wisconsin 54-1255) (Penicillium chrysogenum).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Aspergillaceae; Penicillium;
OC   Penicillium chrysogenum species complex.
OX   NCBI_TaxID=500485 {ECO:0000313|EMBL:CAP85403.1, ECO:0000313|Proteomes:UP000000724};
RN   [1] {ECO:0000313|EMBL:CAP85403.1, ECO:0000313|Proteomes:UP000000724}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 28089 / DSM 1075 / NRRL 1951 / Wisconsin 54-1255
RC   {ECO:0000313|Proteomes:UP000000724};
RX   PubMed=18820685; DOI=10.1038/nbt.1498;
RA   van den Berg M.A., Albang R., Albermann K., Badger J.H., Daran J.-M.,
RA   Driessen A.J.M., Garcia-Estrada C., Fedorova N.D., Harris D.M.,
RA   Heijne W.H.M., Joardar V.S., Kiel J.A.K.W., Kovalchuk A., Martin J.F.,
RA   Nierman W.C., Nijland J.G., Pronk J.T., Roubos J.A.,
RA   van der Klei I.J., van Peij N.N.M.E., Veenhuis M., von Doehren H.,
RA   Wagner C., Wortman J.R., Bovenberg R.A.L.;
RT   "Genome sequencing and analysis of the filamentous fungus Penicillium
RT   chrysogenum.";
RL   Nat. Biotechnol. 26:1161-1168(2008).
CC   -!- FUNCTION: May be involved in the degradation of misfolded
CC       endoplasmic reticulum (ER) luminal proteins.
CC       {ECO:0000256|RuleBase:RU363059}.
CC   -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC       {ECO:0000256|RuleBase:RU363059}; Multi-pass membrane protein
CC       {ECO:0000256|RuleBase:RU363059}.
CC   -!- SIMILARITY: Belongs to the derlin family.
CC       {ECO:0000256|RuleBase:RU363059}.
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DR   EMBL; AM920435; CAP85403.1; -; Genomic_DNA.
DR   RefSeq; XP_002562636.1; XM_002562590.1.
DR   STRING; 500485.XP_002562636.1; -.
DR   EnsemblFungi; CAP85403; CAP85403; PCH_Pc20g00740.
DR   GeneID; 8307731; -.
DR   KEGG; pcs:Pc20g00740; -.
DR   eggNOG; KOG0858; Eukaryota.
DR   eggNOG; COG5291; LUCA.
DR   HOGENOM; HOG000171884; -.
DR   OMA; TYIWCQL; -.
DR   OrthoDB; EOG092C45T6; -.
DR   BioCyc; PCHR:PC20G00740-MONOMER; -.
DR   Proteomes; UP000000724; Contig Pc00c20.
DR   GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0004252; F:serine-type endopeptidase activity; IEA:InterPro.
DR   Gene3D; 1.20.1540.10; -; 1.
DR   InterPro; IPR007599; DER1.
DR   InterPro; IPR022764; Peptidase_S54_rhomboid_dom.
DR   PANTHER; PTHR11009; PTHR11009; 1.
DR   SUPFAM; SSF144091; SSF144091; 1.
PE   3: Inferred from homology;
DR   PRODOM; B6HGC5.
DR   SWISS-2DPAGE; B6HGC5.
KW   Complete proteome {ECO:0000313|Proteomes:UP000000724};
KW   Endoplasmic reticulum {ECO:0000256|RuleBase:RU363059};
KW   Membrane {ECO:0000256|RuleBase:RU363059};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000724};
KW   Transmembrane {ECO:0000256|RuleBase:RU363059};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU363059}.
FT   TRANSMEM     23     45       Helical. {ECO:0000256|RuleBase:RU363059}.
FT   TRANSMEM     52     73       Helical. {ECO:0000256|RuleBase:RU363059}.
FT   TRANSMEM     88    114       Helical. {ECO:0000256|RuleBase:RU363059}.
FT   TRANSMEM    135    155       Helical. {ECO:0000256|RuleBase:RU363059}.
SQ   SEQUENCE   256 AA;  28310 MW;  20775BA19F73D060 CRC64;
     MDVFWAAPPV TRTLTALTLV QSALMYGGLL SFYWAPFLPS LIFSWRPQIY RLVTPFLLTG
     PKLGFFFDLY IMYRYGSAAE KSMAPGEFLI YLLFVAFSIM LTAGGYLGAA ILLPPLTMAF
     VYTFSQTNRG TKTRFWFIDI PVVFLPYAML LVTMVSNGWD AALVESTGIL AAHTYDFLTR
     IYPTFGGGRN FITVPGFLER YFTEHDPNSG YRGYGTASRA PRPAGQPSSA SASGSTWGSW
     TSSSSWNGRG AGRRLG
//

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