(data stored in ACNUC8465 zone)

SWISSPROT: B6HGS4_PENRW

ID   B6HGS4_PENRW            Unreviewed;       688 AA.
AC   B6HGS4;
DT   16-DEC-2008, integrated into UniProtKB/TrEMBL.
DT   16-DEC-2008, sequence version 1.
DT   30-AUG-2017, entry version 71.
DE   RecName: Full=Histone-lysine N-methyltransferase {ECO:0000256|PROSITE-ProRule:PRU00901};
DE            EC=2.1.1.43 {ECO:0000256|PROSITE-ProRule:PRU00901};
GN   ORFNames=Pc20g01100 {ECO:0000313|EMBL:CAP85439.1}, PCH_Pc20g01100
GN   {ECO:0000313|EMBL:CAP85439.1};
OS   Penicillium rubens (strain ATCC 28089 / DSM 1075 / NRRL 1951 /
OS   Wisconsin 54-1255) (Penicillium chrysogenum).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Aspergillaceae; Penicillium;
OC   Penicillium chrysogenum species complex.
OX   NCBI_TaxID=500485 {ECO:0000313|EMBL:CAP85439.1, ECO:0000313|Proteomes:UP000000724};
RN   [1] {ECO:0000313|EMBL:CAP85439.1, ECO:0000313|Proteomes:UP000000724}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 28089 / DSM 1075 / NRRL 1951 / Wisconsin 54-1255
RC   {ECO:0000313|Proteomes:UP000000724};
RX   PubMed=18820685; DOI=10.1038/nbt.1498;
RA   van den Berg M.A., Albang R., Albermann K., Badger J.H., Daran J.-M.,
RA   Driessen A.J.M., Garcia-Estrada C., Fedorova N.D., Harris D.M.,
RA   Heijne W.H.M., Joardar V.S., Kiel J.A.K.W., Kovalchuk A., Martin J.F.,
RA   Nierman W.C., Nijland J.G., Pronk J.T., Roubos J.A.,
RA   van der Klei I.J., van Peij N.N.M.E., Veenhuis M., von Doehren H.,
RA   Wagner C., Wortman J.R., Bovenberg R.A.L.;
RT   "Genome sequencing and analysis of the filamentous fungus Penicillium
RT   chrysogenum.";
RL   Nat. Biotechnol. 26:1161-1168(2008).
CC   -!- CATALYTIC ACTIVITY: S-adenosyl-L-methionine + L-lysine-[histone] =
CC       S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[histone].
CC       {ECO:0000256|PROSITE-ProRule:PRU00901,
CC       ECO:0000256|SAAS:SAAS00591578}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|SAAS:SAAS00574581}.
CC   -!- SIMILARITY: Belongs to the class V-like SAM-binding
CC       methyltransferase superfamily. Histone-lysine methyltransferase
CC       family. SET2 subfamily. {ECO:0000256|PROSITE-ProRule:PRU00901}.
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DR   EMBL; AM920435; CAP85439.1; -; Genomic_DNA.
DR   RefSeq; XP_002562671.1; XM_002562625.1.
DR   STRING; 500485.XP_002562671.1; -.
DR   EnsemblFungi; CAP85439; CAP85439; PCH_Pc20g01100.
DR   GeneID; 8312247; -.
DR   KEGG; pcs:Pc20g01100; -.
DR   eggNOG; KOG4442; Eukaryota.
DR   eggNOG; COG2940; LUCA.
DR   HOGENOM; HOG000172130; -.
DR   KO; K11423; -.
DR   OMA; YVDKWVV; -.
DR   OrthoDB; EOG092C3T9B; -.
DR   BioCyc; PCHR:PC20G01100-MONOMER; -.
DR   Proteomes; UP000000724; Contig Pc00c20.
DR   GO; GO:0016591; C:DNA-directed RNA polymerase II, holoenzyme; IEA:EnsemblFungi.
DR   GO; GO:0046975; F:histone methyltransferase activity (H3-K36 specific); IEA:UniProtKB-UniRule.
DR   GO; GO:0006368; P:transcription elongation from RNA polymerase II promoter; IEA:EnsemblFungi.
DR   CDD; cd00201; WW; 1.
DR   InterPro; IPR006560; AWS_dom.
DR   InterPro; IPR025788; Hist-Lys_N-MeTrfase_SET2_fun.
DR   InterPro; IPR003616; Post-SET_dom.
DR   InterPro; IPR001214; SET_dom.
DR   InterPro; IPR017923; TFIIS_N.
DR   InterPro; IPR001202; WW_dom.
DR   Pfam; PF00856; SET; 1.
DR   SMART; SM00570; AWS; 1.
DR   SMART; SM00508; PostSET; 1.
DR   SMART; SM00317; SET; 1.
DR   SMART; SM00456; WW; 1.
DR   SUPFAM; SSF47676; SSF47676; 1.
DR   SUPFAM; SSF51045; SSF51045; 1.
DR   PROSITE; PS51215; AWS; 1.
DR   PROSITE; PS50868; POST_SET; 1.
DR   PROSITE; PS51568; SAM_MT43_SET2_1; 1.
DR   PROSITE; PS50280; SET; 1.
DR   PROSITE; PS01159; WW_DOMAIN_1; 1.
DR   PROSITE; PS50020; WW_DOMAIN_2; 1.
PE   3: Inferred from homology;
DR   PRODOM; B6HGS4.
DR   SWISS-2DPAGE; B6HGS4.
KW   Complete proteome {ECO:0000313|Proteomes:UP000000724};
KW   Methyltransferase {ECO:0000256|PROSITE-ProRule:PRU00901,
KW   ECO:0000256|SAAS:SAAS00590675};
KW   Nucleus {ECO:0000256|SAAS:SAAS00574642};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000724};
KW   S-adenosyl-L-methionine {ECO:0000256|PROSITE-ProRule:PRU00901,
KW   ECO:0000256|SAAS:SAAS00591079};
KW   Transferase {ECO:0000256|PROSITE-ProRule:PRU00901,
KW   ECO:0000256|SAAS:SAAS00591533}.
FT   DOMAIN      121    176       AWS. {ECO:0000259|PROSITE:PS51215}.
FT   DOMAIN      178    295       SET. {ECO:0000259|PROSITE:PS50280}.
FT   DOMAIN      302    318       Post-SET. {ECO:0000259|PROSITE:PS50868}.
FT   DOMAIN      560    591       WW. {ECO:0000259|PROSITE:PS50020}.
SQ   SEQUENCE   688 AA;  77791 MW;  E8A379D195EB55C6 CRC64;
     MSAHDYADSE EPAKMERDSP VNGNHLKNGD SRTSSRSPLP PKKESSPNSD APDPMKENIG
     EIVLKQEPGQ PPKLSRSSSQ KVASRPPPLY THLPDSTQDA LATFEQIPGC IYANKYMGYT
     EHAMECDCAE EWDPKIGRNI ACGEDSDCIN RATKIECAGE CGCGPDCQNQ RFQKRQFAPV
     SVIKTEKKGF GLRAEKNLDP GELIYEYVGE VVGEQQFRKR MRQYDEEGIK HFYFMSLNKG
     EFVDATKRGN LGRFCNHSCN PNCYVDKWVV GEKLRMGIFA ERAVQAGEEL VFNYNVDRYG
     ADPQPCYCGE PMCTGFIGGR TQTERATKLS NATIEALGID EADGWDTVVA KRPKKKKMEE
     DDEEYVDSVQ PKSLDEDGVT KVMAALVQCQ EKWIAVKLLG RIQRCDDERV RNRVVRMHGY
     QILNSQLAQW KEDQNVVLQI LNILDGFPRL TRNKIQDSKI ETNIRPLTTC DDERVPKKAV
     ALLESWAGLE VAYRIPRMKR GKDAKQAINQ FERRETGQEQ RQRSLTRSPS PVYDAPRGPA
     QQRRDRGPQR SRQPNRRGPR PLPEGWYTAE AEGRVYYYSA SGKTTWERPT LPATPATPAP
     GQPAKNQQNL ALQSIIDGIM NTQEDTPSEN RTATPVTPQP SADQPERRHK DGEKWRKLPL
     EKQKRIYENT VTFPAYQARG GSVQTQDP
//

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