(data stored in ACNUC8465 zone)

SWISSPROT: B6HH38_PENRW

ID   B6HH38_PENRW            Unreviewed;       247 AA.
AC   B6HH38;
DT   16-DEC-2008, integrated into UniProtKB/TrEMBL.
DT   16-DEC-2008, sequence version 1.
DT   07-JUN-2017, entry version 53.
DE   RecName: Full=Eukaryotic translation initiation factor 6 {ECO:0000256|HAMAP-Rule:MF_03132};
DE            Short=eIF-6 {ECO:0000256|HAMAP-Rule:MF_03132};
GN   Name=TIF6 {ECO:0000256|HAMAP-Rule:MF_03132};
GN   ORFNames=Pc20g01120 {ECO:0000313|EMBL:CAP85441.1}, PCH_Pc20g01120
GN   {ECO:0000313|EMBL:CAP85441.1};
OS   Penicillium rubens (strain ATCC 28089 / DSM 1075 / NRRL 1951 /
OS   Wisconsin 54-1255) (Penicillium chrysogenum).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Aspergillaceae; Penicillium;
OC   Penicillium chrysogenum species complex.
OX   NCBI_TaxID=500485 {ECO:0000313|EMBL:CAP85441.1, ECO:0000313|Proteomes:UP000000724};
RN   [1] {ECO:0000313|EMBL:CAP85441.1, ECO:0000313|Proteomes:UP000000724}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 28089 / DSM 1075 / NRRL 1951 / Wisconsin 54-1255
RC   {ECO:0000313|Proteomes:UP000000724};
RX   PubMed=18820685; DOI=10.1038/nbt.1498;
RA   van den Berg M.A., Albang R., Albermann K., Badger J.H., Daran J.-M.,
RA   Driessen A.J.M., Garcia-Estrada C., Fedorova N.D., Harris D.M.,
RA   Heijne W.H.M., Joardar V.S., Kiel J.A.K.W., Kovalchuk A., Martin J.F.,
RA   Nierman W.C., Nijland J.G., Pronk J.T., Roubos J.A.,
RA   van der Klei I.J., van Peij N.N.M.E., Veenhuis M., von Doehren H.,
RA   Wagner C., Wortman J.R., Bovenberg R.A.L.;
RT   "Genome sequencing and analysis of the filamentous fungus Penicillium
RT   chrysogenum.";
RL   Nat. Biotechnol. 26:1161-1168(2008).
CC   -!- FUNCTION: Binds to the 60S ribosomal subunit and prevents its
CC       association with the 40S ribosomal subunit to form the 80S
CC       initiation complex in the cytoplasm. Is also involved in ribosome
CC       biogenesis. Associates with pre-60S subunits in the nucleus and is
CC       involved in its nuclear export. {ECO:0000256|HAMAP-Rule:MF_03132}.
CC   -!- SUBUNIT: Monomer. Associates with the 60S ribosomal subunit.
CC       {ECO:0000256|HAMAP-Rule:MF_03132}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_03132}.
CC       Nucleus, nucleolus {ECO:0000256|HAMAP-Rule:MF_03132}.
CC       Note=Shuttles between cytoplasm and nucleus/nucleolus.
CC       {ECO:0000256|HAMAP-Rule:MF_03132}.
CC   -!- PTM: Phosphorylation at Ser-174 and Ser-175 promotes nuclear
CC       export. {ECO:0000256|HAMAP-Rule:MF_03132}.
CC   -!- SIMILARITY: Belongs to the eIF-6 family. {ECO:0000256|HAMAP-
CC       Rule:MF_03132}.
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DR   EMBL; AM920435; CAP85441.1; -; Genomic_DNA.
DR   RefSeq; XP_002562673.1; XM_002562627.1.
DR   ProteinModelPortal; B6HH38; -.
DR   STRING; 500485.XP_002562673.1; -.
DR   EnsemblFungi; CAP85441; CAP85441; PCH_Pc20g01120.
DR   GeneID; 8312249; -.
DR   KEGG; pcs:Pc20g01120; -.
DR   eggNOG; KOG3185; Eukaryota.
DR   eggNOG; COG1976; LUCA.
DR   HOGENOM; HOG000230605; -.
DR   KO; K03264; -.
DR   OMA; TAGNRHG; -.
DR   OrthoDB; EOG092C4BDP; -.
DR   BioCyc; PCHR:PC20G01120-MONOMER; -.
DR   Proteomes; UP000000724; Contig Pc00c20.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR   GO; GO:0043023; F:ribosomal large subunit binding; IEA:UniProtKB-HAMAP.
DR   GO; GO:0043022; F:ribosome binding; IEA:InterPro.
DR   GO; GO:0003743; F:translation initiation factor activity; IEA:UniProtKB-HAMAP.
DR   GO; GO:0042256; P:mature ribosome assembly; IEA:UniProtKB-HAMAP.
DR   GO; GO:0042273; P:ribosomal large subunit biogenesis; IEA:UniProtKB-HAMAP.
DR   GO; GO:0000054; P:ribosomal subunit export from nucleus; IEA:UniProtKB-HAMAP.
DR   CDD; cd00527; IF6; 1.
DR   HAMAP; MF_00032; eIF_6; 1.
DR   InterPro; IPR002769; eIF6.
DR   PANTHER; PTHR10784; PTHR10784; 1.
DR   Pfam; PF01912; eIF-6; 1.
DR   PIRSF; PIRSF006413; IF-6; 1.
DR   SMART; SM00654; eIF6; 1.
DR   TIGRFAMs; TIGR00323; eIF-6; 1.
PE   3: Inferred from homology;
DR   PRODOM; B6HH38.
DR   SWISS-2DPAGE; B6HH38.
KW   Complete proteome {ECO:0000313|Proteomes:UP000000724};
KW   Cytoplasm {ECO:0000256|HAMAP-Rule:MF_03132};
KW   Initiation factor {ECO:0000256|HAMAP-Rule:MF_03132};
KW   Nucleus {ECO:0000256|HAMAP-Rule:MF_03132};
KW   Phosphoprotein {ECO:0000256|HAMAP-Rule:MF_03132};
KW   Protein biosynthesis {ECO:0000256|HAMAP-Rule:MF_03132};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000724};
KW   Ribosome biogenesis {ECO:0000256|HAMAP-Rule:MF_03132}.
FT   MOD_RES     174    174       Phosphoserine; by CK1.
FT                                {ECO:0000256|HAMAP-Rule:MF_03132}.
FT   MOD_RES     175    175       Phosphoserine; by CK1.
FT                                {ECO:0000256|HAMAP-Rule:MF_03132}.
SQ   SEQUENCE   247 AA;  26362 MW;  2769483EF594590A CRC64;
     MAVRAQFENS NEVGVFSCLT NAYAIVAVGA SENFYSVFES ELQDVIPICH ATIAGTRIVG
     RLIVGNRKGL LVPTTTTDQE LQHLRNTLPA EVKIQRIEER LSALGNVICC NDHVAIVHPD
     LERETEEIIA DVLGVEVFRQ TVADNVLTGS YMALSNQGGI VHPKTSIRDQ DELSSLLQVP
     LVAGSVNRGS PVVGAGMVVN DWLAITGLDT TATELSVVES VFRLGEMAPG GAGGAAVNKD
     SIVESFY
//

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