(data stored in ACNUC8465 zone)

SWISSPROT: B6HED9_PENRW

ID   B6HED9_PENRW            Unreviewed;       185 AA.
AC   B6HED9;
DT   16-DEC-2008, integrated into UniProtKB/TrEMBL.
DT   16-DEC-2008, sequence version 1.
DT   07-JUN-2017, entry version 59.
DE   RecName: Full=3-hydroxyanthranilate 3,4-dioxygenase {ECO:0000256|HAMAP-Rule:MF_03019};
DE            EC=1.13.11.6 {ECO:0000256|HAMAP-Rule:MF_03019};
DE   AltName: Full=3-hydroxyanthranilate oxygenase {ECO:0000256|HAMAP-Rule:MF_03019};
DE            Short=3-HAO {ECO:0000256|HAMAP-Rule:MF_03019};
DE   AltName: Full=3-hydroxyanthranilic acid dioxygenase {ECO:0000256|HAMAP-Rule:MF_03019};
DE            Short=HAD {ECO:0000256|HAMAP-Rule:MF_03019};
DE   AltName: Full=Biosynthesis of nicotinic acid protein 1 {ECO:0000256|HAMAP-Rule:MF_03019};
GN   Name=BNA1 {ECO:0000256|HAMAP-Rule:MF_03019};
GN   ORFNames=Pc20g02370 {ECO:0000313|EMBL:CAP85566.1}, PCH_Pc20g02370
GN   {ECO:0000313|EMBL:CAP85566.1};
OS   Penicillium rubens (strain ATCC 28089 / DSM 1075 / NRRL 1951 /
OS   Wisconsin 54-1255) (Penicillium chrysogenum).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Aspergillaceae; Penicillium;
OC   Penicillium chrysogenum species complex.
OX   NCBI_TaxID=500485 {ECO:0000313|EMBL:CAP85566.1, ECO:0000313|Proteomes:UP000000724};
RN   [1] {ECO:0000313|EMBL:CAP85566.1, ECO:0000313|Proteomes:UP000000724}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 28089 / DSM 1075 / NRRL 1951 / Wisconsin 54-1255
RC   {ECO:0000313|Proteomes:UP000000724};
RX   PubMed=18820685; DOI=10.1038/nbt.1498;
RA   van den Berg M.A., Albang R., Albermann K., Badger J.H., Daran J.-M.,
RA   Driessen A.J.M., Garcia-Estrada C., Fedorova N.D., Harris D.M.,
RA   Heijne W.H.M., Joardar V.S., Kiel J.A.K.W., Kovalchuk A., Martin J.F.,
RA   Nierman W.C., Nijland J.G., Pronk J.T., Roubos J.A.,
RA   van der Klei I.J., van Peij N.N.M.E., Veenhuis M., von Doehren H.,
RA   Wagner C., Wortman J.R., Bovenberg R.A.L.;
RT   "Genome sequencing and analysis of the filamentous fungus Penicillium
RT   chrysogenum.";
RL   Nat. Biotechnol. 26:1161-1168(2008).
CC   -!- FUNCTION: Catalyzes the oxidative ring opening of 3-
CC       hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde,
CC       which spontaneously cyclizes to quinolinate. {ECO:0000256|HAMAP-
CC       Rule:MF_03019}.
CC   -!- CATALYTIC ACTIVITY: 3-hydroxyanthranilate + O(2) = 2-amino-3-
CC       carboxymuconate semialdehyde. {ECO:0000256|HAMAP-Rule:MF_03019}.
CC   -!- COFACTOR:
CC       Name=Fe(2+); Xref=ChEBI:CHEBI:29033; Evidence={ECO:0000256|HAMAP-
CC         Rule:MF_03019};
CC   -!- PATHWAY: Cofactor biosynthesis; NAD(+) biosynthesis; quinolinate
CC       from L-kynurenine: step 3/3. {ECO:0000256|HAMAP-Rule:MF_03019}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_03019}.
CC   -!- SIMILARITY: Belongs to the 3-HAO family. {ECO:0000256|HAMAP-
CC       Rule:MF_03019}.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|HAMAP-Rule:MF_03019}.
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DR   EMBL; AM920435; CAP85566.1; -; Genomic_DNA.
DR   RefSeq; XP_002562791.1; XM_002562745.1.
DR   STRING; 500485.XP_002562791.1; -.
DR   EnsemblFungi; CAP85566; CAP85566; PCH_Pc20g02370.
DR   GeneID; 8307183; -.
DR   KEGG; pcs:Pc20g02370; -.
DR   eggNOG; KOG3995; Eukaryota.
DR   eggNOG; ENOG4111GH8; LUCA.
DR   HOGENOM; HOG000218448; -.
DR   KO; K00452; -.
DR   OMA; IREEAFH; -.
DR   OrthoDB; EOG092C5CUF; -.
DR   BioCyc; PCHR:PC20G02370-MONOMER; -.
DR   UniPathway; UPA00253; UER00330.
DR   Proteomes; UP000000724; Contig Pc00c20.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0000334; F:3-hydroxyanthranilate 3,4-dioxygenase activity; IEA:UniProtKB-HAMAP.
DR   GO; GO:0008198; F:ferrous iron binding; IEA:UniProtKB-HAMAP.
DR   GO; GO:0034354; P:'de novo' NAD biosynthetic process from tryptophan; IEA:UniProtKB-HAMAP.
DR   GO; GO:0043420; P:anthranilate metabolic process; IEA:UniProtKB-HAMAP.
DR   GO; GO:0019805; P:quinolinate biosynthetic process; IEA:UniProtKB-HAMAP.
DR   GO; GO:0006569; P:tryptophan catabolic process; IEA:UniProtKB-HAMAP.
DR   Gene3D; 2.60.120.10; -; 1.
DR   HAMAP; MF_00825; 3_HAO; 1.
DR   InterPro; IPR010329; 3hydroanth_dOase.
DR   InterPro; IPR014710; RmlC-like_jellyroll.
DR   InterPro; IPR011051; RmlC_Cupin.
DR   PANTHER; PTHR15497; PTHR15497; 1.
DR   Pfam; PF06052; 3-HAO; 1.
DR   SUPFAM; SSF51182; SSF51182; 1.
DR   TIGRFAMs; TIGR03037; anthran_nbaC; 1.
PE   3: Inferred from homology;
DR   PRODOM; B6HED9.
DR   SWISS-2DPAGE; B6HED9.
KW   Complete proteome {ECO:0000313|Proteomes:UP000000724};
KW   Cytoplasm {ECO:0000256|HAMAP-Rule:MF_03019};
KW   Dioxygenase {ECO:0000256|HAMAP-Rule:MF_03019};
KW   Iron {ECO:0000256|HAMAP-Rule:MF_03019};
KW   Metal-binding {ECO:0000256|HAMAP-Rule:MF_03019};
KW   Oxidoreductase {ECO:0000256|HAMAP-Rule:MF_03019};
KW   Pyridine nucleotide biosynthesis {ECO:0000256|HAMAP-Rule:MF_03019};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000724}.
FT   METAL        58     58       Iron; catalytic. {ECO:0000256|HAMAP-Rule:
FT                                MF_03019}.
FT   METAL        64     64       Iron; catalytic. {ECO:0000256|HAMAP-Rule:
FT                                MF_03019}.
FT   METAL       103    103       Iron; catalytic. {ECO:0000256|HAMAP-Rule:
FT                                MF_03019}.
FT   BINDING      54     54       Dioxygen. {ECO:0000256|HAMAP-Rule:
FT                                MF_03019}.
FT   BINDING      64     64       Substrate. {ECO:0000256|HAMAP-Rule:
FT                                MF_03019}.
FT   BINDING     107    107       Substrate. {ECO:0000256|HAMAP-Rule:
FT                                MF_03019}.
FT   BINDING     117    117       Substrate. {ECO:0000256|HAMAP-Rule:
FT                                MF_03019}.
SQ   SEQUENCE   185 AA;  21098 MW;  1FD52E3078FA7E27 CRC64;
     MEHASSAQTS IPGPVTLHSW LSANAQKLQP PVNNQCLYSG KDFILMAVGG PNTRNDYHIN
     QTEEWFYQIK GDMLLKIVEN GTCFRDIEIR EGEMFLLPGD IPHCPIRYEE TIGLVMERTR
     PPHVVDRIRW YCPNADAHRT VPSIIREESF HCADIETQLK DLINHWMTDE STRKCGGCGE
     IAPPH
//

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