(data stored in ACNUC8465 zone)

SWISSPROT: B6HF56_PENRW

ID   B6HF56_PENRW            Unreviewed;      1697 AA.
AC   B6HF56;
DT   16-DEC-2008, integrated into UniProtKB/TrEMBL.
DT   16-DEC-2008, sequence version 1.
DT   07-JUN-2017, entry version 62.
DE   RecName: Full=DNA polymerase {ECO:0000256|RuleBase:RU000442};
DE            EC=2.7.7.7 {ECO:0000256|RuleBase:RU000442};
GN   ORFNames=Pc20g02960 {ECO:0000313|EMBL:CAP85625.1}, PCH_Pc20g02960
GN   {ECO:0000313|EMBL:CAP85625.1};
OS   Penicillium rubens (strain ATCC 28089 / DSM 1075 / NRRL 1951 /
OS   Wisconsin 54-1255) (Penicillium chrysogenum).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Aspergillaceae; Penicillium;
OC   Penicillium chrysogenum species complex.
OX   NCBI_TaxID=500485 {ECO:0000313|EMBL:CAP85625.1, ECO:0000313|Proteomes:UP000000724};
RN   [1] {ECO:0000313|EMBL:CAP85625.1, ECO:0000313|Proteomes:UP000000724}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 28089 / DSM 1075 / NRRL 1951 / Wisconsin 54-1255
RC   {ECO:0000313|Proteomes:UP000000724};
RX   PubMed=18820685; DOI=10.1038/nbt.1498;
RA   van den Berg M.A., Albang R., Albermann K., Badger J.H., Daran J.-M.,
RA   Driessen A.J.M., Garcia-Estrada C., Fedorova N.D., Harris D.M.,
RA   Heijne W.H.M., Joardar V.S., Kiel J.A.K.W., Kovalchuk A., Martin J.F.,
RA   Nierman W.C., Nijland J.G., Pronk J.T., Roubos J.A.,
RA   van der Klei I.J., van Peij N.N.M.E., Veenhuis M., von Doehren H.,
RA   Wagner C., Wortman J.R., Bovenberg R.A.L.;
RT   "Genome sequencing and analysis of the filamentous fungus Penicillium
RT   chrysogenum.";
RL   Nat. Biotechnol. 26:1161-1168(2008).
CC   -!- CATALYTIC ACTIVITY: Deoxynucleoside triphosphate + DNA(n) =
CC       diphosphate + DNA(n+1). {ECO:0000256|RuleBase:RU000442}.
CC   -!- COFACTOR:
CC       Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883;
CC         Evidence={ECO:0000256|RuleBase:RU000442};
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|RuleBase:RU000442}.
CC   -!- SIMILARITY: Belongs to the DNA polymerase type-B family.
CC       {ECO:0000256|RuleBase:RU000442}.
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DR   EMBL; AM920435; CAP85625.1; -; Genomic_DNA.
DR   RefSeq; XP_002562849.1; XM_002562803.1.
DR   STRING; 500485.XP_002562849.1; -.
DR   EnsemblFungi; CAP85625; CAP85625; PCH_Pc20g02960.
DR   GeneID; 8317525; -.
DR   KEGG; pcs:Pc20g02960; -.
DR   eggNOG; KOG0968; Eukaryota.
DR   eggNOG; COG0417; LUCA.
DR   HOGENOM; HOG000194392; -.
DR   KO; K02350; -.
DR   OMA; WYDEMPK; -.
DR   OrthoDB; EOG092C0C07; -.
DR   BioCyc; PCHR:PC20G02960-MONOMER; -.
DR   Proteomes; UP000000724; Contig Pc00c20.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0008408; F:3'-5' exonuclease activity; IEA:InterPro.
DR   GO; GO:0051539; F:4 iron, 4 sulfur cluster binding; IEA:UniProtKB-KW.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0000166; F:nucleotide binding; IEA:InterPro.
DR   GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR   Gene3D; 3.30.420.10; -; 1.
DR   Gene3D; 3.90.1600.10; -; 1.
DR   InterPro; IPR006172; DNA-dir_DNA_pol_B.
DR   InterPro; IPR017964; DNA-dir_DNA_pol_B_CS.
DR   InterPro; IPR006133; DNA-dir_DNA_pol_B_exonuc.
DR   InterPro; IPR006134; DNA-dir_DNA_pol_B_multi_dom.
DR   InterPro; IPR023211; DNA_pol_palm_dom.
DR   InterPro; IPR012337; RNaseH-like_dom.
DR   InterPro; IPR025687; Znf-C4pol.
DR   Pfam; PF00136; DNA_pol_B; 1.
DR   Pfam; PF03104; DNA_pol_B_exo1; 2.
DR   Pfam; PF14260; zf-C4pol; 1.
DR   PRINTS; PR00106; DNAPOLB.
DR   SMART; SM00486; POLBc; 1.
DR   SUPFAM; SSF53098; SSF53098; 3.
DR   PROSITE; PS00116; DNA_POLYMERASE_B; 1.
PE   3: Inferred from homology;
DR   PRODOM; B6HF56.
DR   SWISS-2DPAGE; B6HF56.
KW   4Fe-4S {ECO:0000256|RuleBase:RU000442};
KW   Complete proteome {ECO:0000313|Proteomes:UP000000724};
KW   DNA replication {ECO:0000256|RuleBase:RU000442};
KW   DNA-binding {ECO:0000256|RuleBase:RU000442};
KW   DNA-directed DNA polymerase {ECO:0000256|RuleBase:RU000442};
KW   Iron {ECO:0000256|RuleBase:RU000442};
KW   Iron-sulfur {ECO:0000256|RuleBase:RU000442};
KW   Metal-binding {ECO:0000256|RuleBase:RU000442};
KW   Nucleotidyltransferase {ECO:0000256|RuleBase:RU000442};
KW   Nucleus {ECO:0000256|RuleBase:RU000442};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000724};
KW   Transferase {ECO:0000256|RuleBase:RU000442};
KW   Zinc {ECO:0000256|RuleBase:RU000442};
KW   Zinc-finger {ECO:0000256|RuleBase:RU000442}.
FT   DOMAIN       49    193       DNA_pol_B_exo1. {ECO:0000259|Pfam:
FT                                PF03104}.
FT   DOMAIN      838   1032       DNA_pol_B_exo1. {ECO:0000259|Pfam:
FT                                PF03104}.
FT   DOMAIN     1092   1544       DNA_pol_B. {ECO:0000259|Pfam:PF00136}.
FT   DOMAIN     1594   1666       zf-C4pol. {ECO:0000259|Pfam:PF14260}.
SQ   SEQUENCE   1697 AA;  192645 MW;  F7936A85C6EE93E3 CRC64;
     MEPFRVRLNC IDHYQATASE LDPPLLFRDE VSEKDFKPKV PVIRIFGATE TGQRVCVHVH
     GAFPYLYIEY NGSLAPEDVN SAIRTLHLSI DHALAVSFRR NAYDRRTAFV AHITLVKGVP
     FYGYHVGWRF FFKIYLLNPF HMTRLVDLLH QGAVMKRPLQ PYEAHVQYIP QWMCDYNLYG
     CAIMSCSQAK FRAPVPEYFE LSNLAHRWHD RSILPESILD HPALQKQSHC ALEVDVCVQD
     ILNRLDVKER PLHHDFTELL KPVAVNERLV PSVAGLWQDE TRRRKKRMGL TDPGSTPFGP
     EELVSMSADP RDQSKGGWIH EEEFREMASQ LAANEKQADG GKDTSFGTFL DTDDQAKYVK
     TALDSTEDFF PGKISTSTFD SSRSQEPAEQ KLSEISVDEG LALSSQTDGQ YYSDSDQGGH
     SLEGIIEHEP ETKQDPLGDS FYDEIFDEMP FLDVAAPAES AETNCPEAAM DGGYKEGDYV
     AQERRPRDQS QNKSVAPKRQ RSETLDCHHS PTKRARHIAE HGLSDGPLES PNTRKHQQDD
     KPKNVSFDSN LDSHAETPSS ESKSSSQRTV RPKAHSYTSG LKFPVVKDPN DPLTILRYSQ
     DEATSSRKDP ESSQPLLNSF PSGSATELSG KTSETQSSSE LHSSATVMGP VSLDPHLSQT
     VKSIRQSFSF APNTSLHCFK FASPTFSEVS SSINEHGRPS VVYQKAFYSD EADVPERPRE
     YGGREFRLES NTIHYLPDFD PTAEAPAMFG EQTPTAHDRD QQEKVDQQLR EWCTSKVWEF
     APVPPSRSEV IRWFEELEAS QEPDRKAAQP IPPEMKSNLL SQIEGPTQKN AHGFKYSQNG
     VSTSVEHQAQ HMSTMSLEVH VNTRGTLMPN PEEDEITSLF WCIQSEDEDI EVNSHLPGVH
     VGMVYHGEGE RPEAKISKAL TIDVEHEPTE LDLINRLIDI VRYYDPDIIT GYEVHNASWG
     YVIERARKKY DFDICEELSR TKSQSNGRFG KEADQWGFNH SSSIRITGRH MFNIWRAMKS
     ELNLLQYTME NVVFHVLHRR IPHYSPKHLT QWHQSGRPRN ILKVVQYFTS RVQMNLEILE
     ANELTPRTSE QARLLGIDFA SVITRGSQFK VESLMFRIAK PENFLLVSPS RKQVGQQNAL
     ECLPLVMEPQ SDFYTSPLLV LDFQSLYPSV MIAYNYCYST FLGRAMHWRG RDKMGFIDYK
     RQPRILELLK DKINIAPNGM MYAKQEARQS LLAKMLSEIL ETRVMVKNGM KADKDDKVLQ
     RLLNNRQLAL KLIANVTYGY TSASFSGRMP CSEIADSIVQ TGRETLEKAI AFIHSVERWG
     AEVVYGDTDS LFVYLKGRTR DQAFDIGEEI AQAVTDLNPR PVKLKFEKVY HPCVLLAKKR
     YVGFKYEHRN QKEPEFDAKG IETVRRDGTP AEQKIEEKAL KTLFRTADLS QVKSYFQRQC
     AKIMQGRISI QDFCFAREVR LGTYSDRHLP AGAVISTKRM LEDPRSEPQT GERVPYVVVT
     GAPGARLVDR CVAPQTLLHD AQLELDAEYY ITKNIIPPLE RIFNLVGANV RQWYDEMPKV
     QRIRRVEGSA LARPNSVGGA SRKTLESYMR SSSCVVCRSR LSDAAVPVCG DCLQKPHLTL
     LDVVSRLQRA EKRVVDLEAI CRSCMGVSPG DEVSCDSLDC PIFYSRARDA ANWRHSKAVL
     EPVVELLERK GDEGLDW
//

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