(data stored in ACNUC8465 zone)

SWISSPROT: B6H1G9_PENRW

ID   B6H1G9_PENRW            Unreviewed;       172 AA.
AC   B6H1G9;
DT   16-DEC-2008, integrated into UniProtKB/TrEMBL.
DT   16-DEC-2008, sequence version 1.
DT   08-MAY-2019, entry version 61.
DE   RecName: Full=Mediator of RNA polymerase II transcription subunit 10 {ECO:0000256|RuleBase:RU364146};
DE   AltName: Full=Mediator complex subunit 10 {ECO:0000256|RuleBase:RU364146};
GN   Name=MED10 {ECO:0000256|RuleBase:RU364146};
GN   ORFNames=Pc13g02400 {ECO:0000313|EMBL:CAP91309.1}, PCH_Pc13g02400
GN   {ECO:0000313|EMBL:CAP91309.1};
OS   Penicillium rubens (strain ATCC 28089 / DSM 1075 / NRRL 1951 /
OS   Wisconsin 54-1255) (Penicillium chrysogenum).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Aspergillaceae; Penicillium;
OC   Penicillium chrysogenum species complex.
OX   NCBI_TaxID=500485 {ECO:0000313|EMBL:CAP91309.1, ECO:0000313|Proteomes:UP000000724};
RN   [1] {ECO:0000313|EMBL:CAP91309.1, ECO:0000313|Proteomes:UP000000724}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 28089 / DSM 1075 / NRRL 1951 / Wisconsin 54-1255
RC   {ECO:0000313|Proteomes:UP000000724};
RX   PubMed=18820685; DOI=10.1038/nbt.1498;
RA   van den Berg M.A., Albang R., Albermann K., Badger J.H., Daran J.-M.,
RA   Driessen A.J.M., Garcia-Estrada C., Fedorova N.D., Harris D.M.,
RA   Heijne W.H.M., Joardar V.S., Kiel J.A.K.W., Kovalchuk A., Martin J.F.,
RA   Nierman W.C., Nijland J.G., Pronk J.T., Roubos J.A.,
RA   van der Klei I.J., van Peij N.N.M.E., Veenhuis M., von Doehren H.,
RA   Wagner C., Wortman J.R., Bovenberg R.A.L.;
RT   "Genome sequencing and analysis of the filamentous fungus Penicillium
RT   chrysogenum.";
RL   Nat. Biotechnol. 26:1161-1168(2008).
CC   -!- FUNCTION: Component of the Mediator complex, a coactivator
CC       involved in the regulated transcription of nearly all RNA
CC       polymerase II-dependent genes. Mediator functions as a bridge to
CC       convey information from gene-specific regulatory proteins to the
CC       basal RNA polymerase II transcription machinery. Mediator is
CC       recruited to promoters by direct interactions with regulatory
CC       proteins and serves as a scaffold for the assembly of a functional
CC       preinitiation complex with RNA polymerase II and the general
CC       transcription factors. {ECO:0000256|RuleBase:RU364146}.
CC   -!- SUBUNIT: Component of the Mediator complex.
CC       {ECO:0000256|RuleBase:RU364146}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|RuleBase:RU364146}.
CC   -!- SIMILARITY: Belongs to the Mediator complex subunit 10 family.
CC       {ECO:0000256|RuleBase:RU364146}.
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DR   EMBL; AM920428; CAP91309.1; -; Genomic_DNA.
DR   RefSeq; XP_002558681.1; XM_002558635.1.
DR   STRING; 1108849.XP_002558681.1; -.
DR   EnsemblFungi; CAP91309; CAP91309; PCH_Pc13g02400.
DR   GeneID; 8314695; -.
DR   KEGG; pcs:Pc13g02400; -.
DR   eggNOG; KOG3046; Eukaryota.
DR   eggNOG; ENOG4111QA2; LUCA.
DR   HOGENOM; HOG000048306; -.
DR   KO; K15151; -.
DR   OMA; RNEQVKG; -.
DR   OrthoDB; 1403581at2759; -.
DR   BioCyc; PCHR:PC13G02400-MONOMER; -.
DR   Proteomes; UP000000724; Contig Pc00c13.
DR   GO; GO:0016592; C:mediator complex; IEA:InterPro.
DR   GO; GO:0003712; F:transcription coregulator activity; IEA:InterPro.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IEA:InterPro.
DR   InterPro; IPR019145; Mediator_Med10.
DR   Pfam; PF09748; Med10; 1.
PE   3: Inferred from homology;
DR   PRODOM; B6H1G9.
DR   SWISS-2DPAGE; B6H1G9.
KW   Activator {ECO:0000256|RuleBase:RU364146};
KW   Complete proteome {ECO:0000313|Proteomes:UP000000724};
KW   Nucleus {ECO:0000256|RuleBase:RU364146};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000724};
KW   Transcription {ECO:0000256|RuleBase:RU364146};
KW   Transcription regulation {ECO:0000256|RuleBase:RU364146}.
SQ   SEQUENCE   172 AA;  18712 MW;  8572AB6673447FF8 CRC64;
     MAPVTLKTVD DDLKDVIQHL FEIQSAVHGY LGPETQQELV RKIKNLTLAL STLSTHTQLP
     PTQENQPDAN TDPSNPSLAS IQLPPEIIDY VDSARNPDIY TREFVELVQR GNQDLRGKRE
     AFASFRDVLA REMRSAMPEC RGEVDRVVAA TSGAVDGPDG ATEAAATSGG LN
//

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