(data stored in ACNUC8465 zone)

SWISSPROT: B6H1G1_PENRW

ID   B6H1G1_PENRW            Unreviewed;       460 AA.
AC   B6H1G1;
DT   16-DEC-2008, integrated into UniProtKB/TrEMBL.
DT   16-DEC-2008, sequence version 1.
DT   05-JUL-2017, entry version 57.
DE   RecName: Full=Elongation factor 1-alpha {ECO:0000256|RuleBase:RU000325};
GN   ORFNames=Pc13g02940 {ECO:0000313|EMBL:CAP91363.1}, PCH_Pc13g02940
GN   {ECO:0000313|EMBL:CAP91363.1};
OS   Penicillium rubens (strain ATCC 28089 / DSM 1075 / NRRL 1951 /
OS   Wisconsin 54-1255) (Penicillium chrysogenum).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Aspergillaceae; Penicillium;
OC   Penicillium chrysogenum species complex.
OX   NCBI_TaxID=500485 {ECO:0000313|EMBL:CAP91363.1, ECO:0000313|Proteomes:UP000000724};
RN   [1] {ECO:0000313|EMBL:CAP91363.1, ECO:0000313|Proteomes:UP000000724}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 28089 / DSM 1075 / NRRL 1951 / Wisconsin 54-1255
RC   {ECO:0000313|Proteomes:UP000000724};
RX   PubMed=18820685; DOI=10.1038/nbt.1498;
RA   van den Berg M.A., Albang R., Albermann K., Badger J.H., Daran J.-M.,
RA   Driessen A.J.M., Garcia-Estrada C., Fedorova N.D., Harris D.M.,
RA   Heijne W.H.M., Joardar V.S., Kiel J.A.K.W., Kovalchuk A., Martin J.F.,
RA   Nierman W.C., Nijland J.G., Pronk J.T., Roubos J.A.,
RA   van der Klei I.J., van Peij N.N.M.E., Veenhuis M., von Doehren H.,
RA   Wagner C., Wortman J.R., Bovenberg R.A.L.;
RT   "Genome sequencing and analysis of the filamentous fungus Penicillium
RT   chrysogenum.";
RL   Nat. Biotechnol. 26:1161-1168(2008).
CC   -!- FUNCTION: This protein promotes the GTP-dependent binding of
CC       aminoacyl-tRNA to the A-site of ribosomes during protein
CC       biosynthesis. {ECO:0000256|RuleBase:RU000325}.
CC   -!- SIMILARITY: Belongs to the TRAFAC class translation factor GTPase
CC       superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A
CC       subfamily. {ECO:0000256|RuleBase:RU000325}.
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DR   EMBL; AM920428; CAP91363.1; -; Genomic_DNA.
DR   RefSeq; XP_002558732.1; XM_002558686.1.
DR   ProteinModelPortal; B6H1G1; -.
DR   STRING; 500485.XP_002558732.1; -.
DR   EnsemblFungi; CAP91363; CAP91363; PCH_Pc13g02940.
DR   GeneID; 8314749; -.
DR   KEGG; pcs:Pc13g02940; -.
DR   eggNOG; KOG0052; Eukaryota.
DR   eggNOG; COG5256; LUCA.
DR   HOGENOM; HOG000229291; -.
DR   KO; K03231; -.
DR   OMA; WYKGWTK; -.
DR   OrthoDB; EOG092C2HV8; -.
DR   BioCyc; PCHR:PC13G02940-MONOMER; -.
DR   Proteomes; UP000000724; Contig Pc00c13.
DR   GO; GO:0005737; C:cytoplasm; IEA:InterPro.
DR   GO; GO:0005525; F:GTP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0003924; F:GTPase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0003746; F:translation elongation factor activity; IEA:UniProtKB-UniRule.
DR   HAMAP; MF_00118_A; EF_Tu_A; 1.
DR   InterPro; IPR004161; EFTu-like_2.
DR   InterPro; IPR031157; G_TR_CS.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR000795; TF_GTP-bd_dom.
DR   InterPro; IPR009000; Transl_B-barrel.
DR   InterPro; IPR009001; Transl_elong_EF1A/Init_IF2_C.
DR   InterPro; IPR004539; Transl_elong_EF1A_euk/arc.
DR   InterPro; IPR004160; Transl_elong_EFTu/EF1A_C.
DR   Pfam; PF00009; GTP_EFTU; 1.
DR   Pfam; PF03144; GTP_EFTU_D2; 1.
DR   Pfam; PF03143; GTP_EFTU_D3; 1.
DR   PRINTS; PR00315; ELONGATNFCT.
DR   SUPFAM; SSF50447; SSF50447; 1.
DR   SUPFAM; SSF50465; SSF50465; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR00483; EF-1_alpha; 1.
DR   PROSITE; PS00301; G_TR_1; 1.
DR   PROSITE; PS51722; G_TR_2; 1.
PE   3: Inferred from homology;
DR   PRODOM; B6H1G1.
DR   SWISS-2DPAGE; B6H1G1.
KW   Complete proteome {ECO:0000313|Proteomes:UP000000724};
KW   Elongation factor {ECO:0000256|RuleBase:RU000325};
KW   GTP-binding {ECO:0000256|RuleBase:RU000325};
KW   Nucleotide-binding {ECO:0000256|RuleBase:RU000325};
KW   Protein biosynthesis {ECO:0000256|RuleBase:RU000325};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000724}.
FT   DOMAIN        6    241       Tr-type G (guanine nucleotide-binding).
FT                                {ECO:0000259|PROSITE:PS51722}.
SQ   SEQUENCE   460 AA;  49758 MW;  76722CD68C201F93 CRC64;
     MGKEERSHLN IVVIGHVDSG KSTTTGHMIY KCGGIDQRTI EKFEKEAAEL GKGSFKYAWV
     LDKLKAERER GITIDIALWK FQTSKYEVTV IDAPGHRDFI KNMITGTSQA DCAILIIASG
     TGEFEAGISK DGQTREHALL AFTLGVKQLI VALNKMDTCK WSEERYNEIV KETSNFIKKV
     GYNPKAVPFV PISGFNGDNM LEASTNCPWY KGWEKETKAG KATGKTLLEA IDAIEPPVRP
     SNKPLRLPLQ DVYKISGIGT VPVGRVETGI ISPGMVVTFA PANVTTEVKS VEMHHQQLKA
     GNPGDNVGFN VKNVSVKEVR RGNVASDSKN DPAAGCDSFN AQVIVLNHPG QVGAGYAPVL
     DCHTAHIACK FAELLEKIDR RTGKATETSP KFIKSGDAAI VKMVPSKPMC VETFTDYPPL
     GRFAVRDMRQ TVAVGVIKSV VKNAGGAGKV TKAAAKAGKK
//

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